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PE20231553A1 - Proceso para preparar carbamato de metil {4,6-diamino-2-[5-fluoro-1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il} - Google Patents

Proceso para preparar carbamato de metil {4,6-diamino-2-[5-fluoro-1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}

Info

Publication number
PE20231553A1
PE20231553A1 PE2022002944A PE2022002944A PE20231553A1 PE 20231553 A1 PE20231553 A1 PE 20231553A1 PE 2022002944 A PE2022002944 A PE 2022002944A PE 2022002944 A PE2022002944 A PE 2022002944A PE 20231553 A1 PE20231553 A1 PE 20231553A1
Authority
PE
Peru
Prior art keywords
compound
dmso
formula
fluorobenzyl
pyrazolo
Prior art date
Application number
PE2022002944A
Other languages
English (en)
Inventor
Peter Fey
Nadine Bremeyer
Markus Longerich
Thomas Frenzel
Helene Faber
Michal Sowa
Joerg Brockob
Guido Becker
Heike Neumann
Original Assignee
Adverio Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adverio Pharma Gmbh filed Critical Adverio Pharma Gmbh
Publication of PE20231553A1 publication Critical patent/PE20231553A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

REFERIDO A UN PROCESO PARA PREPARAR CARBAMATO DE METIL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-B]PIRIDIN-3-IL]PIRIMIDIN-5-IL} DE FORMULA (I) EN FORMA CRISTALINA DE LA MODIFICACION I, DONDE EL DIFRACTOGRAMA DE RAYOS X DE DICHO COMPUESTO PRESENTA MAXIMOS PICO DE ANGULO 2 THETA EN 5.9, 6.9, 22.7; EN DONDE EL CLORHIDRATO DEL COMPUESTO (I) SE PREPARA CALENTANDO EL COMPUESTO DE FORMULA (IX) EN TETRAHIDROFURANO COMO SOLVENTE, AGREGANDO 1,0 EQ. A 1,2 EQ. CLOROFORMATO DE METILO, AGITANDO DENTRO DE UN TIEMPO DE REACCION DE 1H A 10H, Y AISLANDO EL CLORHIDRATO DEL COMPUESTO (I), LUEGO EL SOLVATO DE DI-DMSO DEL COMPUESTO DE FORMULA (I) SE PREPARA DISOLVIENDO EL CLORHIDRATO DEL COMPUESTO DE LA FORMULA (I) EN DMSO, ANADIENDO TRI-N-BUTILAMINA Y CARBONO ACTIVADO, RETIRANDO EL CARBONO ACTIVADO, CRISTALIZANDO EL SOLVATO DE DI-DMSO POR ENFRIAMIENTO Y ANADIENDO ACETATO DE ETILO, AISLANDO EL DI-DMSO EN FORMA CRISTALIZADA, Y LAVANDO CON UNA MEZCLA DE DMSO Y ACETATO DE ETILO; POSTERIORMENTE SE PREPARA LA FORMA CRISTALINA DE LA MODIFICACION I DEL COMPUESTO (I).
PE2022002944A 2020-06-16 2021-06-15 Proceso para preparar carbamato de metil {4,6-diamino-2-[5-fluoro-1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il} PE20231553A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20180229.5A EP3925953A1 (en) 2020-06-16 2020-06-16 Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
PCT/EP2021/066019 WO2021254981A1 (en) 2020-06-16 2021-06-15 Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate

Publications (1)

Publication Number Publication Date
PE20231553A1 true PE20231553A1 (es) 2023-10-03

Family

ID=71103286

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022002944A PE20231553A1 (es) 2020-06-16 2021-06-15 Proceso para preparar carbamato de metil {4,6-diamino-2-[5-fluoro-1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}

Country Status (17)

Country Link
US (1) US20230219952A1 (es)
EP (2) EP3925953A1 (es)
JP (1) JP7783201B2 (es)
KR (1) KR20230025862A (es)
CN (3) CN119954803A (es)
AR (1) AR122635A1 (es)
AU (1) AU2021294233A1 (es)
BR (1) BR112022023035A2 (es)
CA (1) CA3187147A1 (es)
CL (1) CL2022003600A1 (es)
CO (1) CO2022018232A2 (es)
CR (1) CR20220647A (es)
IL (1) IL298913A (es)
MX (1) MX2022015952A (es)
PE (1) PE20231553A1 (es)
TW (1) TWI889841B (es)
WO (1) WO2021254981A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI830835B (zh) * 2018-12-17 2024-02-01 德商亞德維瑞醫藥有限公司 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物
ES2956054B2 (es) * 2022-05-03 2024-07-01 Moehs Iberica Sl 2-(5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL)-5-NITROSOPIRIMIDIN-4,6-DIAMINA O UNA SAL DE LA MISMA, PROCEDIMIENTO PARA SU PREPARACION Y SU USO EN LA SINTESIS DE VERICIGUAT
CN115043835B (zh) * 2022-06-17 2023-05-09 常州制药厂有限公司 一种维立西呱的精制纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE10021069A1 (de) * 2000-04-28 2001-10-31 Bayer Ag Substituiertes Pyrazolderivat
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
ES2553035T3 (es) * 2009-11-27 2015-12-03 Adverio Pharma Gmbh Procedimiento para la preparación de {4,6-diamino-2-[1-(2-fluorobencil)-1H-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}-metilcarbamato de metilo y su purificación para el uso como principio activo farmacéutico
UY33041A (es) 2009-11-27 2011-06-30 Bayer Schering Pharma Aktienegesellschaft Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
DE102010021637A1 (de) * 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
NZ603799A (en) * 2010-05-26 2014-10-31 Bayer Ip Gmbh The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc).
DE102010040233A1 (de) * 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
EP2751106B1 (de) * 2011-09-02 2017-10-18 Bayer Intellectual Property GmbH Substituierte annellierte pyrimidine und ihre verwendung
EP2594197A1 (en) * 2011-11-21 2013-05-22 Technische Universität München Tracking system and method
EA031602B1 (ru) * 2011-11-25 2019-01-31 Адверио Фарма Гмбх Способы получения альдегидов
TWI830835B (zh) 2018-12-17 2024-02-01 德商亞德維瑞醫藥有限公司 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物
JP7471306B2 (ja) 2019-01-22 2024-04-19 アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ４－（２，２，３，３－テトラフルオロプロピル）モルホリンを製造する方法

Also Published As

Publication number Publication date
IL298913A (en) 2023-02-01
CN115697978A (zh) 2023-02-03
EP4165028A1 (en) 2023-04-19
TWI889841B (zh) 2025-07-11
EP3925953A1 (en) 2021-12-22
TW202214625A (zh) 2022-04-16
CL2022003600A1 (es) 2023-04-28
BR112022023035A2 (pt) 2022-12-27
CR20220647A (es) 2023-03-03
AR122635A1 (es) 2022-09-28
CN119954803A (zh) 2025-05-09
KR20230025862A (ko) 2023-02-23
AU2021294233A1 (en) 2022-12-22
MX2022015952A (es) 2023-01-24
US20230219952A1 (en) 2023-07-13
WO2021254981A1 (en) 2021-12-23
CA3187147A1 (en) 2021-12-23
CN119954802A (zh) 2025-05-09
CN115697978B (zh) 2025-02-28
CO2022018232A2 (es) 2022-12-20
JP7783201B2 (ja) 2025-12-09
JP2023530142A (ja) 2023-07-13

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