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PE20230092A1 - Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceuticas y uso del mismo - Google Patents

Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceuticas y uso del mismo

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Publication number
PE20230092A1
PE20230092A1 PE2022000742A PE2022000742A PE20230092A1 PE 20230092 A1 PE20230092 A1 PE 20230092A1 PE 2022000742 A PE2022000742 A PE 2022000742A PE 2022000742 A PE2022000742 A PE 2022000742A PE 20230092 A1 PE20230092 A1 PE 20230092A1
Authority
PE
Peru
Prior art keywords
dihydroimidazopyrimidone
preparation
pharmaceutical composition
absent
compound
Prior art date
Application number
PE2022000742A
Other languages
English (en)
Inventor
Yun Jin
Jinhua Wu
Jun Peng
Yong Sun
Original Assignee
Shanghai Simr Biotechnology Co Ltd
Shanghai Simrd Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=75750506&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20230092(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shanghai Simr Biotechnology Co Ltd, Shanghai Simrd Biotechnology Co Ltd filed Critical Shanghai Simr Biotechnology Co Ltd
Publication of PE20230092A1 publication Critical patent/PE20230092A1/es

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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Referido a un compuesto de formula I, isomero cis-trans, enantiomero, diasteroisomero del mismo, entre otros; en donde n 0, 1 o 2, y cuando n es 0, R2 es metilo o etilo; cuando n es 1 o 2 R2 esta ausente; R1 es H, halogeno, ciano, entre otros; Ra es independientemente H o D; m es 1 o 2; Rx es H, halogeno, hidroxilo, carboxilo, entre otros; Q es -O-, -S-, -CH2-, o -NRb-; X es -O-, -CH2-, entre otros; Y es -CH2-, -CH2CH2-, o esta ausente; U es -CH2-, -C(O)-, o esta ausente. Este compuesto derivado triciclico de dihidroimidazopirimidona es inhibidor de Lp-PLA2. Tambien se refiere a una composicion que comprende dicho compuesto, metodos para su preparacion, compuestos intermedios, y su uso en el tratamiento o prevencion del Alzheimer, o aterosclerosis.
PE2022000742A 2019-11-09 2020-11-09 Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceuticas y uso del mismo PE20230092A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911104067 2019-11-09
PCT/CN2020/127426 WO2021089032A1 (zh) 2019-11-09 2020-11-09 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途

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PE20230092A1 true PE20230092A1 (es) 2023-01-16

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CN116854680A (zh) 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途
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