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PE20200387A1 - Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer - Google Patents

Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer

Info

Publication number
PE20200387A1
PE20200387A1 PE2019001563A PE2019001563A PE20200387A1 PE 20200387 A1 PE20200387 A1 PE 20200387A1 PE 2019001563 A PE2019001563 A PE 2019001563A PE 2019001563 A PE2019001563 A PE 2019001563A PE 20200387 A1 PE20200387 A1 PE 20200387A1
Authority
PE
Peru
Prior art keywords
cancer
treatment
compounds
alkyl
elaboration
Prior art date
Application number
PE2019001563A
Other languages
English (en)
Inventor
Sriram Naganathan
Nathan Guz
Matthew Pfeiffer
C Gregory Sowell
Tracy Bostick
Jason Yang
Amit Srivastava
Original Assignee
Exelixis Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Genentech Inc filed Critical Exelixis Inc
Publication of PE20200387A1 publication Critical patent/PE20200387A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Referido a un proceso para elaborar un compuesto de formula I, donde A es arileno o heteroarileno opcionalmente sustituido; X es alquilo, halo, haloalquilo (C1-C8), entre otros; R1, R2, R3 y R4 son cada uno independientemente H, alquilo (C1-C8), entre otros; R5 es H, halo, o alquilo (C1-C8). Estos compuestos inhiben MEK y son utiles en el tratamiento de trastornos hiperproliferativos, tal como el cancer.
PE2019001563A 2012-10-12 2019-08-08 Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer PE20200387A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713104P 2012-10-12 2012-10-12
PCT/US2013/064866 WO2014059422A1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
PE20200387A1 true PE20200387A1 (es) 2020-02-24

Family

ID=49474740

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2019002024A PE20191818A1 (es) 2012-10-12 2013-10-14 Proceso para la elaboracion de 1-({3,4-difluoro-2-[(2-fluoro-4-yodofenil)amino]fenil}carbonil)-3-[(2s)-piperidin-2-il]azetidin-3ol
PE2015000485A PE20151494A1 (es) 2012-10-12 2013-10-14 Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer
PE2019001563A PE20200387A1 (es) 2012-10-12 2019-08-08 Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE2019002024A PE20191818A1 (es) 2012-10-12 2013-10-14 Proceso para la elaboracion de 1-({3,4-difluoro-2-[(2-fluoro-4-yodofenil)amino]fenil}carbonil)-3-[(2s)-piperidin-2-il]azetidin-3ol
PE2015000485A PE20151494A1 (es) 2012-10-12 2013-10-14 Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer

Country Status (31)

Country Link
US (4) US9771347B2 (es)
EP (1) EP2909188B1 (es)
JP (2) JP6300042B2 (es)
KR (1) KR102204520B1 (es)
CN (2) CN104837826B (es)
AU (1) AU2013328929B2 (es)
BR (1) BR112015008113B1 (es)
CA (1) CA2889466C (es)
CL (1) CL2015000926A1 (es)
CR (2) CR20200237A (es)
EA (1) EA030613B1 (es)
ES (1) ES2671502T3 (es)
GE (1) GEP201706690B (es)
HK (1) HK1213567A1 (es)
HR (1) HRP20180670T1 (es)
IL (1) IL238116B (es)
IN (1) IN2015DN03928A (es)
MA (1) MA38085B1 (es)
MX (2) MX372708B (es)
MY (1) MY186549A (es)
NZ (1) NZ706723A (es)
PE (3) PE20191818A1 (es)
PH (1) PH12015500785B1 (es)
PL (1) PL2909188T3 (es)
SA (1) SA515360271B1 (es)
SG (1) SG11201502795VA (es)
SI (1) SI2909188T1 (es)
TR (1) TR201807861T4 (es)
UA (1) UA115455C2 (es)
WO (1) WO2014059422A1 (es)
ZA (1) ZA201502349B (es)

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Also Published As

Publication number Publication date
CL2015000926A1 (es) 2015-08-28
WO2014059422A1 (en) 2014-04-17
AU2013328929A1 (en) 2015-04-30
ZA201502349B (en) 2019-12-18
SA515360271B1 (ar) 2016-05-19
US20200392104A1 (en) 2020-12-17
CN104837826A (zh) 2015-08-12
PH12015500785A1 (en) 2015-06-15
EA201590700A1 (ru) 2015-09-30
NZ706723A (en) 2018-07-27
ES2671502T3 (es) 2018-06-06
PE20191818A1 (es) 2019-12-27
SI2909188T1 (en) 2018-07-31
MA38085B1 (fr) 2018-11-30
US20190185447A1 (en) 2019-06-20
GEP201706690B (en) 2017-06-26
MX372708B (es) 2020-05-29
US10793541B2 (en) 2020-10-06
CN108948043A (zh) 2018-12-07
MA38085A1 (fr) 2018-08-31
MX2020005533A (es) 2020-10-12
CA2889466A1 (en) 2014-04-17
HRP20180670T1 (hr) 2018-07-13
US10239858B2 (en) 2019-03-26
TR201807861T4 (tr) 2018-06-21
IL238116B (en) 2018-06-28
US11414396B2 (en) 2022-08-16
EP2909188A1 (en) 2015-08-26
CN108948043B (zh) 2021-05-04
JP6300042B2 (ja) 2018-03-28
IN2015DN03928A (es) 2015-10-02
JP2015533175A (ja) 2015-11-19
PH12015500785B1 (en) 2015-06-15
CA2889466C (en) 2021-09-14
UA115455C2 (uk) 2017-11-10
SG11201502795VA (en) 2015-05-28
HK1213567A1 (zh) 2016-07-08
US9771347B2 (en) 2017-09-26
BR112015008113A2 (pt) 2017-07-04
AU2013328929B2 (en) 2018-01-04
KR102204520B1 (ko) 2021-01-20
EP2909188B1 (en) 2018-03-07
US20170349569A1 (en) 2017-12-07
JP2018052973A (ja) 2018-04-05
CR20200237A (es) 2020-07-26
MY186549A (en) 2021-07-26
US20150210668A1 (en) 2015-07-30
CN104837826B (zh) 2018-07-27
MX2015004660A (es) 2015-08-07
PL2909188T3 (pl) 2018-08-31
EA030613B1 (ru) 2018-08-31
BR112015008113B1 (pt) 2022-05-24
KR20150067339A (ko) 2015-06-17
HK1213878A1 (en) 2016-07-15
CR20150245A (es) 2015-11-19
PE20151494A1 (es) 2015-11-06

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