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PE20190731A1 - Compuestos heterociclicos como inmunomoduladores - Google Patents

Compuestos heterociclicos como inmunomoduladores

Info

Publication number
PE20190731A1
PE20190731A1 PE2018003268A PE2018003268A PE20190731A1 PE 20190731 A1 PE20190731 A1 PE 20190731A1 PE 2018003268 A PE2018003268 A PE 2018003268A PE 2018003268 A PE2018003268 A PE 2018003268A PE 20190731 A1 PE20190731 A1 PE 20190731A1
Authority
PE
Peru
Prior art keywords
carboxamide
compounds
immunomodulators
protein
ring
Prior art date
Application number
PE2018003268A
Other languages
English (en)
Inventor
Kaijiong Xiao
Fenglei Zhang
Liangxing Wu
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20190731A1 publication Critical patent/PE20190731A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se refiere a un compuesto de Formula (I) o una sal farmaceuticamente aceptable, donde G1 es NR6, G2 es CR7R7; X1, X2 y X3 es N; Z es O, S, N, entre otros; Cy es arilo C6-10, cicloalquilo C3-10, heteroarilo de 5 a 14 miembros o heterocicloalquilo de 4 a 10 miembros, entre otros; R5, R6 y R7 pueden ser H, halo, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, haloalquilo C1-C6, entre otros; Y1 e Y2 pueden ser N o C, siempre que Y1 e Y2 no sean simultaneamente N; el anillo A es un anillo aromatico y el subindice n es un numero entero de 1, 2, 3 o 4. Son compuestos preferidos N-(2-cianobifenil-3-il)-4,5,6,7-tetrahidro[1,3]tiazolo[5,4-c]piridin-2-carboxamida; N-[2-ciano-3-(2,3-dihidro-1,4-benzodioxin-6-il)fenil]-4,5,6,7-tetrahidropirazolo[1,5-a]pirazin-2-carboxamida. Dichos compuestos modulan la interaccion proteina/proteina de PD -1/PD-L1 y son utiles en el tratamiento de varias enfermedades que incluyen enfermedades infecciosas y cancer.
PE2018003268A 2016-06-20 2017-06-19 Compuestos heterociclicos como inmunomoduladores PE20190731A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662352485P 2016-06-20 2016-06-20
US201662396353P 2016-09-19 2016-09-19

Publications (1)

Publication Number Publication Date
PE20190731A1 true PE20190731A1 (es) 2019-05-23

Family

ID=59258383

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018003268A PE20190731A1 (es) 2016-06-20 2017-06-19 Compuestos heterociclicos como inmunomoduladores

Country Status (32)

Country Link
US (4) US20170362253A1 (es)
EP (2) EP4137489A1 (es)
JP (2) JP7000357B2 (es)
KR (1) KR102685249B1 (es)
CN (1) CN109890819B (es)
AU (2) AU2017281285C1 (es)
BR (1) BR112018076534A2 (es)
CA (1) CA3028685A1 (es)
CL (1) CL2018003701A1 (es)
CO (1) CO2019000386A2 (es)
DK (1) DK3472167T3 (es)
EC (1) ECSP19003773A (es)
ES (1) ES2927984T3 (es)
HR (1) HRP20221030T1 (es)
HU (1) HUE060256T2 (es)
IL (1) IL263825B (es)
LT (1) LT3472167T (es)
MD (1) MD3472167T2 (es)
MX (2) MX389513B (es)
MY (1) MY197280A (es)
PE (1) PE20190731A1 (es)
PH (1) PH12018502710A1 (es)
PL (1) PL3472167T3 (es)
PT (1) PT3472167T (es)
RS (1) RS63673B1 (es)
SG (2) SG11201811414TA (es)
SI (1) SI3472167T1 (es)
SM (1) SMT202200392T1 (es)
TW (1) TWI771305B (es)
UA (1) UA125391C2 (es)
WO (1) WO2017222976A1 (es)
ZA (1) ZA202405294B (es)

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