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PE20181952A1 - Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos - Google Patents

Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos

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Publication number
PE20181952A1
PE20181952A1 PE2018002029A PE2018002029A PE20181952A1 PE 20181952 A1 PE20181952 A1 PE 20181952A1 PE 2018002029 A PE2018002029 A PE 2018002029A PE 2018002029 A PE2018002029 A PE 2018002029A PE 20181952 A1 PE20181952 A1 PE 20181952A1
Authority
PE
Peru
Prior art keywords
cdr
seq
group
kabat numbering
antibody
Prior art date
Application number
PE2018002029A
Other languages
English (en)
Inventor
Laird Bloom
Karl Henry Nocka
James Reasoner Apgar
Mark A Farmer
Matthew Allister Lambert
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20181952A1 publication Critical patent/PE20181952A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Referido a un anticuerpo o fragmento de union al antigeno del mismo, que se une especificamente a interleucina 33 (IL-33) humana, caracterizado porque comprende cualquiera de: (i) una CDR-L1 seleccionada del grupo que consiste de SEQ ID NO: 20, 37, 190, 193, 257, 258, 259 y 260 de acuerdo con la numeracion Kabat; (ii) una CDR-L2 seleccionada del grupo que consiste de SEQ ID NO: 21, 196, 199, 261, 262, 263, y 264 de acuerdo con la numeracion Kabat; (iii) una CDR-L3 seleccionada del grupo que consiste de SEQ ID NO: 22, 38, 208, 265, 26, 267 y 268 de acuerdo con la numeracion Kabat; (iv) una CDR-H1 seleccionada del grupo que consiste de SEQ ID NO: 16, 33, 269, 270 y 271 de acuerdo con la numeracion Kabat; (v) una CDR-H2 seleccionada del grupo que consiste de SEQ ID NO: 17, 34, 168, 171 ,174, 180, 202, 205, 211, 214, 217, 220, 223, 226, 229, 232, 235, 272, 273, 274, y 275 de acuerdo con la numeracion Kabat, y (vi) una CDR-H3 seleccionada del grupo que consiste de SEQ ID NO: 18, 35, 114, 119, 122, 127, 130, 133, 136, 139, 142, 145, 148, 153, 156, 159, 177, 187, 276, 277, 278, y 279 de acuerdo con la numeracion Kabat. En donde, este anticuerpo o fragmento de union al antigeno del mismo, comprende una o ambas secuencias de marco VL y VH es al menos 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o 99% identica a la secuencia de la linea germinal de humano a partir de la cual se deriva. Tambien se refiere a una molecula aislada de acidos nucleicos, un vector, una celula huesped y un metodo para elaborar un anticuerpo. Una composicion farmaceutica que comprende un anticuerpo y metodos para tratar enfermedades inflamatorias, alergias, entre otras.
PE2018002029A 2016-04-27 2017-04-20 Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos PE20181952A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328294P 2016-04-27 2016-04-27
US201762483781P 2017-04-10 2017-04-10

Publications (1)

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PE20181952A1 true PE20181952A1 (es) 2018-12-17

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PE2018002029A PE20181952A1 (es) 2016-04-27 2017-04-20 Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos

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US (2) US10544212B2 (es)
EP (1) EP3448888A1 (es)
JP (1) JP2019516362A (es)
KR (1) KR20180128028A (es)
CN (1) CN109415436A (es)
AU (1) AU2017257330A1 (es)
BR (1) BR112018071276A2 (es)
CA (1) CA2965089A1 (es)
CO (1) CO2018011364A2 (es)
IL (1) IL262497A (es)
MX (1) MX2018013038A (es)
PE (1) PE20181952A1 (es)
PH (1) PH12018502225A1 (es)
RU (1) RU2740309C2 (es)
SG (1) SG11201808693WA (es)
TW (2) TW201943729A (es)
WO (1) WO2017187307A1 (es)

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