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PE20180037A1 - Nuevos derivados de piridina - Google Patents

Nuevos derivados de piridina

Info

Publication number
PE20180037A1
PE20180037A1 PE2017002309A PE2017002309A PE20180037A1 PE 20180037 A1 PE20180037 A1 PE 20180037A1 PE 2017002309 A PE2017002309 A PE 2017002309A PE 2017002309 A PE2017002309 A PE 2017002309A PE 20180037 A1 PE20180037 A1 PE 20180037A1
Authority
PE
Peru
Prior art keywords
pyridine derivatives
new pyridine
formula
new
compound
Prior art date
Application number
PE2017002309A
Other languages
English (en)
Inventor
Caterina Bissantz
Uwe Grether
Atsushi Kimbara
Qingping Liu
Matthias Nettekoven
Marco Prunotto
Stephan Roever
Evans Mark Rogers
Gasch Tanja Schulz
Christoph Ullmer
Zhiwei Wang
Wulun Yang
Paul Hebeisen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20180037A1 publication Critical patent/PE20180037A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

La invencion se refiere a un compuesto derivados de piridina de la formula (I) en la que de R1 a R4 tienen los significados definidos en la descripcion y en las reivindicaciones. El compuesto de la formula (I) es agonista del receptor de canabinoides 2 y es util para el tratamiento del dolor, inflamacion, isquemia, entre otras
PE2017002309A 2011-06-10 2012-06-07 Nuevos derivados de piridina PE20180037A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011075606 2011-06-10

Publications (1)

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PE20180037A1 true PE20180037A1 (es) 2018-01-09

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PE2013002773A PE20141583A1 (es) 2011-06-10 2012-06-07 Nuevos derivados de piridina
PE2017002309A PE20180037A1 (es) 2011-06-10 2012-06-07 Nuevos derivados de piridina

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PE2013002773A PE20141583A1 (es) 2011-06-10 2012-06-07 Nuevos derivados de piridina

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US (2) US9321727B2 (es)
EP (2) EP3072886B1 (es)
JP (3) JP5997265B2 (es)
KR (1) KR20140042848A (es)
CN (2) CN103608332B (es)
AR (1) AR086881A1 (es)
AU (2) AU2012266369B2 (es)
BR (1) BR112013031463A2 (es)
CA (1) CA2835745A1 (es)
CL (1) CL2013003486A1 (es)
CO (1) CO6811864A2 (es)
CR (1) CR20130616A (es)
CY (1) CY1117878T1 (es)
DK (2) DK3072886T3 (es)
EA (2) EA027247B1 (es)
EC (1) ECSP13013074A (es)
ES (2) ES2588327T3 (es)
HR (2) HRP20161064T2 (es)
HU (2) HUE027669T2 (es)
IL (2) IL229685B (es)
LT (1) LT3072886T (es)
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