PE20160692A1 - Pirido[4,3-b]pirazin-2-carboxamidas como agentes neurogenicos para el tratamiento de trastornos neurodegenerativos - Google Patents
Pirido[4,3-b]pirazin-2-carboxamidas como agentes neurogenicos para el tratamiento de trastornos neurodegenerativosInfo
- Publication number
- PE20160692A1 PE20160692A1 PE2016000545A PE2016000545A PE20160692A1 PE 20160692 A1 PE20160692 A1 PE 20160692A1 PE 2016000545 A PE2016000545 A PE 2016000545A PE 2016000545 A PE2016000545 A PE 2016000545A PE 20160692 A1 PE20160692 A1 PE 20160692A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrido
- pyrazine
- carboxamides
- treatment
- neurodegenerative disorders
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 230000001272 neurogenic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- BTNVHBHVDOGDQJ-UHFFFAOYSA-N 8-(4-chlorophenyl)pyrido[3,4-b]pyrazine-2-carboxamide Chemical compound ClC1=CC=C(C=C1)C1=CN=CC=2C1=NC(=CN2)C(=O)N BTNVHBHVDOGDQJ-UHFFFAOYSA-N 0.000 abstract 1
- ZHYWZEZGGPZYLJ-UHFFFAOYSA-N 8-[4-(trifluoromethyl)phenyl]pyrido[3,4-b]pyrazine-2-carboxamide Chemical compound FC(C1=CC=C(C=C1)C1=CN=CC=2C1=NC(=CN2)C(=O)N)(F)F ZHYWZEZGGPZYLJ-UHFFFAOYSA-N 0.000 abstract 1
- IJXCPBHQAQOOJK-UHFFFAOYSA-N 8-bromo-N-(1-cyanocyclopropyl)pyrido[3,4-b]pyrazine-2-carboxamide Chemical compound BrC1=CN=CC=2C1=NC(=CN2)C(=O)NC2(CC2)C#N IJXCPBHQAQOOJK-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000001178 neural stem cell Anatomy 0.000 abstract 1
- 230000004766 neurogenesis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UTPKXLXUFQVLKH-UHFFFAOYSA-N pyrido[3,4-b]pyrazine-2-carboxamide Chemical class N1=C2C(=NC=C1C(=O)N)C=NC=C2 UTPKXLXUFQVLKH-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Abstract
La invencion se refiere a compuestos derivados de pirido[4,3-b]pirazin-2-carboxamidas de formula (I); en donde R1 es hidrogeno; R2 es hidrogeno, alquilo inferior, entre otros; R3 es halogeno, heteroarilo, entre otros. Son compuestos preferidos: 8-(4-clorofenil)-pirido[4,3-b]pirazin-2-carboxamida; 8-(4-(trifluorometil)-fenil)-pirido[4,3-b]pirazin-2-carboxamida; 8-bromo-N-(1-cianociclopropil)-pirido[4,3-b]pirazin-2-carboxamida, entre otros. Tambien se refiere a un proceso de sintesis y a una composicion farmaceutica del compuesto de formula (I). Dichos compuestos estimulan la neurogenesis a partir de celulas madres neurales (CMN), siendo utiles en el tratamiento de transtornos neurodegenerativos como enfermedad de Parkinson, enfermedad de Alzheimer, entre otros
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13192406 | 2013-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160692A1 true PE20160692A1 (es) | 2016-07-28 |
Family
ID=49552255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000545A PE20160692A1 (es) | 2013-11-12 | 2014-11-07 | Pirido[4,3-b]pirazin-2-carboxamidas como agentes neurogenicos para el tratamiento de trastornos neurodegenerativos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9670206B2 (es) |
| EP (1) | EP3068781B1 (es) |
| JP (1) | JP6229056B2 (es) |
| KR (1) | KR101861937B1 (es) |
| CN (1) | CN105764901B (es) |
| AU (1) | AU2014350371B2 (es) |
| CA (1) | CA2929461A1 (es) |
| CL (1) | CL2016001024A1 (es) |
| CR (1) | CR20160142A (es) |
| EA (1) | EA028940B1 (es) |
| IL (1) | IL244619A0 (es) |
| MA (1) | MA39027B1 (es) |
| MX (1) | MX2016006052A (es) |
| PE (1) | PE20160692A1 (es) |
| PH (1) | PH12016500605A1 (es) |
| UA (1) | UA117041C2 (es) |
| WO (1) | WO2015071178A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108430986B (zh) | 2015-10-26 | 2021-08-31 | 拜耳作物科学股份公司 | 作为有害生物控制剂的稠合双环杂环衍生物 |
| KR20210040085A (ko) * | 2018-07-31 | 2021-04-12 | 메르크 파텐트 게엠베하 | Tlr7/8 안타고니스트 및 이의 용도 |
| KR20210133984A (ko) | 2019-02-26 | 2021-11-08 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 축합된 비시클릭 헤테로시클릭 유도체 |
| CN113710669A (zh) | 2019-02-26 | 2021-11-26 | 拜耳公司 | 作为农药的稠合双环杂环衍生物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1773834A2 (en) * | 2004-08-03 | 2007-04-18 | Serenex, Inc. | 2, 8-disubstituted naphthyridine derivatives |
| CN101356173B (zh) * | 2005-11-11 | 2012-10-31 | 阿特纳赞塔里斯有限公司 | 新的吡啶并吡嗪和它们作为激酶调节剂的用途 |
| JP2012519211A (ja) * | 2009-03-02 | 2012-08-23 | サートリス ファーマシューティカルズ， インコーポレイテッド | サーチュイン調節化合物としての８−置換キノリンおよび関連類似体 |
| AR076381A1 (es) * | 2009-04-22 | 2011-06-08 | Janssen Pharmaceutica Nv | Azetidinil diamidas como inhibidores de monoacilglicerol lipasa |
| BR112013000414A2 (pt) * | 2010-07-07 | 2016-05-17 | Univ Texas | compostos proneurogênicos |
| CN105163727B (zh) * | 2013-05-03 | 2018-08-17 | 豪夫迈·罗氏有限公司 | 刺激神经发生的异喹啉衍生物 |
| TWI529171B (zh) * | 2013-07-29 | 2016-04-11 | 赫孚孟拉羅股份公司 | １，７－萘啶衍生物 |
-
2014
- 2014-11-07 CN CN201480061521.6A patent/CN105764901B/zh not_active Expired - Fee Related
- 2014-11-07 JP JP2016530137A patent/JP6229056B2/ja not_active Expired - Fee Related
- 2014-11-07 WO PCT/EP2014/073988 patent/WO2015071178A1/en not_active Ceased
- 2014-11-07 MX MX2016006052A patent/MX2016006052A/es unknown
- 2014-11-07 AU AU2014350371A patent/AU2014350371B2/en not_active Ceased
- 2014-11-07 MA MA39027A patent/MA39027B1/fr unknown
- 2014-11-07 CA CA2929461A patent/CA2929461A1/en not_active Abandoned
- 2014-11-07 KR KR1020167012464A patent/KR101861937B1/ko not_active Expired - Fee Related
- 2014-11-07 UA UAA201606256A patent/UA117041C2/uk unknown
- 2014-11-07 EA EA201690971A patent/EA028940B1/ru not_active IP Right Cessation
- 2014-11-07 PE PE2016000545A patent/PE20160692A1/es unknown
- 2014-11-07 EP EP14796743.4A patent/EP3068781B1/en not_active Not-in-force
-
2016
- 2016-03-16 IL IL244619A patent/IL244619A0/en unknown
- 2016-03-29 CR CR20160142A patent/CR20160142A/es unknown
- 2016-04-04 PH PH12016500605A patent/PH12016500605A1/en unknown
- 2016-04-29 CL CL2016001024A patent/CL2016001024A1/es unknown
- 2016-05-11 US US15/151,698 patent/US9670206B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL244619A0 (en) | 2016-04-21 |
| PH12016500605A1 (en) | 2016-06-13 |
| MA39027B1 (fr) | 2018-10-31 |
| JP6229056B2 (ja) | 2017-11-08 |
| EA201690971A1 (ru) | 2016-08-31 |
| AU2014350371B2 (en) | 2018-02-15 |
| EP3068781A1 (en) | 2016-09-21 |
| CN105764901B (zh) | 2018-06-22 |
| UA117041C2 (uk) | 2018-06-11 |
| US20160251355A1 (en) | 2016-09-01 |
| CR20160142A (es) | 2016-05-04 |
| EP3068781B1 (en) | 2017-12-20 |
| CL2016001024A1 (es) | 2016-11-18 |
| KR20160061427A (ko) | 2016-05-31 |
| HK1223916A1 (zh) | 2017-08-11 |
| JP2016536320A (ja) | 2016-11-24 |
| WO2015071178A1 (en) | 2015-05-21 |
| MX2016006052A (es) | 2016-07-18 |
| CN105764901A (zh) | 2016-07-13 |
| KR101861937B1 (ko) | 2018-05-28 |
| CA2929461A1 (en) | 2015-05-21 |
| EA028940B1 (ru) | 2018-01-31 |
| MA39027A1 (fr) | 2018-05-31 |
| US9670206B2 (en) | 2017-06-06 |
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