PE20181289A1 - 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa - Google Patents
3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasaInfo
- Publication number
- PE20181289A1 PE20181289A1 PE2018001204A PE2018001204A PE20181289A1 PE 20181289 A1 PE20181289 A1 PE 20181289A1 PE 2018001204 A PE2018001204 A PE 2018001204A PE 2018001204 A PE2018001204 A PE 2018001204A PE 20181289 A1 PE20181289 A1 PE 20181289A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- cetohexoquinase
- hexans
- azabicycle
- substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HGWUUOXXAIISDB-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexane Chemical compound C1NCC2CC21 HGWUUOXXAIISDB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 102100023418 Ketohexokinase Human genes 0.000 abstract 1
- 108010062852 Ketohexokinase Proteins 0.000 abstract 1
- 230000010014 adipocyte dysfunction Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
Se refiere a un compuesto derivado de 3-azabiciclo[3.1.0]hexano de formula I, donde R1 es cicloalquilo C3-C7 o una porcion heterociclica de 4 a 7 miembros, donde la porcion heterociclica contiene 1 a 2 atomos de N, O y S; R2 es -(L)m-CON(RN2), -(L)m-SO2RS, entre otros; R4 es ciclopropilo, ciclobutilo, entre otros; Y es N o C-CN; Z es N o CH; X es CR3 donde R3 es H, -CN, halogeno, entre otros.; m y n son 0 o 1; RN y RS son H o -C1-3alquilo, L es CH2, CHF, entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son inhibidores de cetohexoquinasa, principal enzima en el metabolismo de fructosa, y son utiles para el tratamiento de enfermedades tales como la resistencia a la insulina, enfermedad renal, disfuncion del adipocito, entre otras
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272598P | 2015-12-29 | 2015-12-29 | |
| US201662423549P | 2016-11-17 | 2016-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181289A1 true PE20181289A1 (es) | 2018-08-07 |
Family
ID=57755415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018001204A PE20181289A1 (es) | 2015-12-29 | 2016-12-16 | 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa |
Country Status (38)
| Country | Link |
|---|---|
| US (6) | US9809579B2 (es) |
| EP (1) | EP3397631B1 (es) |
| JP (1) | JP6503515B2 (es) |
| KR (1) | KR102073048B1 (es) |
| CN (1) | CN108473469B (es) |
| AU (1) | AU2016380920B2 (es) |
| CA (1) | CA2952466C (es) |
| CL (1) | CL2018001667A1 (es) |
| CO (1) | CO2018006714A2 (es) |
| CU (1) | CU24540B1 (es) |
| CY (1) | CY1124389T1 (es) |
| DK (1) | DK3397631T3 (es) |
| EC (1) | ECSP18048517A (es) |
| ES (1) | ES2871251T3 (es) |
| GE (2) | GEAP202014820A (es) |
| HR (1) | HRP20210769T1 (es) |
| HU (1) | HUE054380T2 (es) |
| IL (1) | IL260330B (es) |
| LT (1) | LT3397631T (es) |
| MA (1) | MA43518B1 (es) |
| MD (1) | MD3397631T2 (es) |
| MX (1) | MX376072B (es) |
| NI (1) | NI201800072A (es) |
| PE (1) | PE20181289A1 (es) |
| PH (1) | PH12018501375A1 (es) |
| PL (1) | PL3397631T3 (es) |
| PT (1) | PT3397631T (es) |
| RS (1) | RS61896B1 (es) |
| RU (1) | RU2696269C1 (es) |
| SG (1) | SG11201804363UA (es) |
| SI (1) | SI3397631T1 (es) |
| SV (1) | SV2018005709A (es) |
| TN (1) | TN2018000198A1 (es) |
| TW (1) | TWI653232B (es) |
| UA (1) | UA121271C2 (es) |
| UY (1) | UY37051A (es) |
| WO (1) | WO2017115205A1 (es) |
| ZA (1) | ZA201803449B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2871251T3 (es) * | 2015-12-29 | 2021-10-28 | Pfizer | 3-Azabiciclo[3.1.0]Hexanos sustituidos como inhibidores de la cetohexocinasa |
| MY199759A (en) | 2016-09-02 | 2023-11-21 | Tisento Therapeutics Inc | Fused bicyclic sgc stimulators |
| US10558874B1 (en) | 2017-01-19 | 2020-02-11 | State Farm Mutual Automobile Insurance Company | Apparatuses, systems and methods for generation and transmission of vehicle operation mode data |
| CN109316601B (zh) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | 药物组合物及其用途 |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| MX2021002428A (es) * | 2018-08-31 | 2023-01-02 | Pfizer | Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas. |
| TWI714231B (zh) | 2018-09-04 | 2020-12-21 | 美商美國禮來大藥廠 | 2,6-二胺基吡啶化合物 |
| KR102558308B1 (ko) * | 2018-09-27 | 2023-07-24 | 주식회사 엘지화학 | 3-아자바이사이클로[3,1,1]헵탄 유도체 및 이를 포함하는 약제학적 조성물 |
| JP7248255B2 (ja) * | 2019-01-29 | 2023-03-29 | シャンドン スアンズ ファーマ カンパニー，リミテッド | ヘキソングルコキナーゼ阻害剤およびその使用 |
| US20220184172A1 (en) * | 2019-04-19 | 2022-06-16 | The Regents Of The University Of California | Ampk/caspase-6 axis controls liver damage in nonalcoholic steatohepatitis |
| ES3039586T3 (en) | 2019-05-20 | 2025-10-22 | Pfizer | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
| CN111978296A (zh) * | 2019-05-22 | 2020-11-24 | 山东轩竹医药科技有限公司 | 己酮糖激酶抑制剂及其用途 |
| AU2020282759A1 (en) | 2019-05-31 | 2021-12-23 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| TWI750685B (zh) * | 2019-06-17 | 2021-12-21 | 美商美國禮來大藥廠 | 二取代吡唑化合物 |
| MX2022007105A (es) | 2019-12-10 | 2022-07-11 | Pfizer | Formas solidas de sal de 1,3-dihidroxi-2-(hidroximetil)propan-2-am ina de acido 2-((4-((s)-2-(5-cloropiridin-2-il)-2-metilbenzo[d][1, 3] dioxol-4-il)piperidin-1-il)metil)-1-(((s)-oxetan-2-il) metil)-1h- benzo[d]imidazol-6-carboxilico. |
| WO2021129737A1 (zh) | 2019-12-24 | 2021-07-01 | 南京明德新药研发有限公司 | 具有khk抑制作用的化合物 |
| WO2021129817A1 (zh) * | 2019-12-25 | 2021-07-01 | 南京明德新药研发有限公司 | 具有果糖激酶(khk)抑制作用的嘧啶类化合物 |
| GB202001856D0 (en) * | 2020-02-11 | 2020-03-25 | Inorbit Therapeutics Ab | Compounds useful in inhibiting ketohexokinase and methods of making and using the same |
| ES2975596T3 (es) * | 2020-02-13 | 2024-07-09 | Lilly Co Eli | Compuestos de 2-[2-metilazetidin-1-il]-4-fenil-6-(trifluorometil)-pirimidina |
| JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
| JP2021134211A (ja) | 2020-02-24 | 2021-09-13 | ファイザー・インク | Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ |
| ES3031577T3 (en) | 2020-03-27 | 2025-07-09 | Pfizer | Treatment of type 2 diabetes with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| TWI810550B (zh) * | 2020-04-20 | 2023-08-01 | 南韓商Ｌｇ化學股份有限公司 | 3-氮雜二環烷基衍生物及包含其之醫藥組成物 |
| CN111423420A (zh) * | 2020-04-30 | 2020-07-17 | 广州博济医药生物技术股份有限公司 | 作为己酮糖激酶抑制剂的并环化合物 |
| CN113754640B (zh) * | 2020-06-03 | 2023-02-14 | 山东轩竹医药科技有限公司 | 氘代的己酮糖激酶抑制剂及其用途 |
| EP4190776A4 (en) * | 2020-07-28 | 2024-02-28 | Shandong Xuanzhu Pharma Co., Ltd. | SALT FORM AND CRYSTAL FORM OF A KETOHEXOKINASE INHIBITOR AND USE THEREOF |
| KR20230093251A (ko) | 2020-09-10 | 2023-06-27 | 프리시릭스 엔.브이. | Fap에 대한 항체 단편 |
| CN114181198B (zh) * | 2020-09-15 | 2025-07-15 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类己酮糖激酶抑制剂及其用途 |
| EP4269404A4 (en) * | 2020-12-25 | 2024-12-04 | Xizang Haisco Pharmaceutical Co., Ltd. | KETOHEXOKINASE INHIBITORS AND USE THEREOF |
| EP4313967B1 (en) | 2021-03-29 | 2025-11-12 | Gilead Sciences, Inc. | Khk inhibitors |
| KR20220136939A (ko) | 2021-04-01 | 2022-10-11 | 주식회사 엘지화학 | 옥사디아졸 화합물 및 이를 포함하는 약제학적 조성물 |
| CN117677615A (zh) * | 2021-06-17 | 2024-03-08 | 杭州中美华东制药有限公司 | 一种螺环化合物的盐型、晶型及其制备方法 |
| US20250129057A1 (en) | 2021-08-31 | 2025-04-24 | Pfizer Inc. | Solid Forms of 2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid, 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-amine Salt |
| CN115974851A (zh) * | 2021-10-14 | 2023-04-18 | 华领医药技术（上海）有限公司 | 2-氧代-3-氮杂双环[3.1.0]己烷衍生物 |
| WO2023111817A1 (en) | 2021-12-17 | 2023-06-22 | Pfizer Inc. | Crystalline forms of [(1r,5s,6r)-3-{2-[(2s)-2-methylazetidin-1-yl]-6-(trifluoromethyl) pyrimidin-4-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid |
| TW202340174A (zh) * | 2021-12-24 | 2023-10-16 | 南韓商Ｌｇ化學股份有限公司 | （ｓ）－２－（２－甲基四氫吖唉－１－基）嘧啶衍生物及包含彼之醫藥組成物 |
| CN114315494B (zh) * | 2021-12-29 | 2023-09-22 | 苏州楚凯药业有限公司 | 一种(s)-2-甲基氮杂环丁烷盐酸盐的制备方法 |
| CN118679155A (zh) * | 2022-02-09 | 2024-09-20 | 上海研健新药研发有限公司 | 一种khk抑制剂，其制备方法和应用 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| KR20250034289A (ko) | 2022-05-02 | 2025-03-11 | 프리시릭스 엔.브이. | 사전 표적화 |
| WO2023228023A1 (en) | 2022-05-23 | 2023-11-30 | Pfizer Inc. | Treatment of type 2 diabetes or weight management control with 2-((4-((s)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-benzo[d]imidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| AU2023364628A1 (en) | 2022-10-18 | 2025-04-03 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
| KR20250174945A (ko) | 2023-04-12 | 2025-12-15 | 센테니얼 테라퓨틱스, 엘엘씨 | 케토헥소키나아제 억제를 위한 이치환 피리미딘 화합물 |
| WO2024249612A1 (en) | 2023-05-31 | 2024-12-05 | Centennial Therapeutics, Llc | Bicyclic compounds for ketohexokinase inhibition |
| WO2025099561A1 (en) | 2023-11-07 | 2025-05-15 | Pfizer Inc. | Oral controlled-release matrix formulations of 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| WO2025224648A1 (en) | 2024-04-26 | 2025-10-30 | Pfizer Inc. | Oral compositions/formulations of 2-({4-[(2s)-2-(4-chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]piperidin-1-yl}methyl)-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980350A (en) | 1988-02-25 | 1990-12-25 | Merck & Co., Inc. | Piperazinylalkylpyrimidines as hypoglycemic agents |
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| ID26984A (id) | 1998-07-06 | 2001-02-22 | Bristol Myers Squibb Co | Senyawa-senyawa sulfonamida sebagai antagonis reseptor angiotensin endotelin ganda |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| WO2002068388A2 (en) | 2001-02-28 | 2002-09-06 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| PL372887A1 (en) | 2002-02-27 | 2005-08-08 | Pfizer Products Inc. | Acc inhibitors |
| JP4227660B2 (ja) | 2004-05-12 | 2009-02-18 | ファイザー・プロダクツ・インク | ジペプチジルペプチダーゼｉｖインヒビターとしてのプロリン誘導体およびそれらの使用 |
| EP1753766A1 (en) | 2004-05-25 | 2007-02-21 | Pfizer Products Inc. | Tetraazabenzo(e)azulene derivatives and analogs thereof |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| SI2463283T1 (sl) | 2006-04-20 | 2014-09-30 | Pfizer Products Inc. | Kondezirane fenil amino heterociklične spojine za preprečevanje in zdravljenje bolezni, ki jih posreduje glukokinaza |
| US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
| WO2008024902A2 (en) | 2006-08-23 | 2008-02-28 | University Of Florida Research Foundation, Inc. | Targeting of fructokinase as therapy for cardiovascular disease, metabolic syndrome, and renal disease |
| US20090270435A1 (en) | 2006-11-29 | 2009-10-29 | Jeffrey Wayne Corbett | Spiroketone Acetyl-CoA Carboxylase Inhibitors |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| ES2404580T3 (es) * | 2007-10-11 | 2013-05-28 | Glaxosmithkline Llc | Novedosos inhibidores de la ehs y uso de los mismos |
| JP2011521940A (ja) | 2008-05-28 | 2011-07-28 | ファイザー・インク | ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤 |
| ES2545231T3 (es) | 2008-05-28 | 2015-09-09 | Pfizer Inc. | Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa |
| US20110130365A1 (en) | 2008-07-29 | 2011-06-02 | Benbow John W | Fluorinated Heteroaryls |
| EP2326640A1 (en) * | 2008-07-30 | 2011-06-01 | Ranbaxy Laboratories Limited | Pyrrole carboxylic acid derivatives as antibacterial agents |
| BRPI0918841B8 (pt) | 2008-08-28 | 2021-05-25 | Pfizer | derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| CN102388038B (zh) | 2009-03-11 | 2014-04-23 | 辉瑞大药厂 | 用作葡糖激酶活化剂的苯并呋喃基衍生物 |
| JP2012520868A (ja) | 2009-03-20 | 2012-09-10 | ファイザー・インク | ３−オキサ−７−アザビシクロ［３．３．１］ノナン |
| AU2010233378A1 (en) * | 2009-04-08 | 2011-11-24 | Actelion Pharmaceuticals Ltd. | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as ADP receptor antagonists |
| CA2759843A1 (en) | 2009-05-08 | 2010-11-10 | Pfizer Inc. | Gpr 119 modulators |
| US20120052130A1 (en) | 2009-05-08 | 2012-03-01 | Pfizer Inc. | Gpr 119 modulators |
| CN102459222B (zh) | 2009-06-05 | 2014-06-04 | 辉瑞大药厂 | 用作gpr119 调节剂的l-(哌啶-4-基)-吡唑衍生物 |
| WO2011005611A1 (en) | 2009-07-09 | 2011-01-13 | Merck Sharp & Dohme Corp. | Neuromedin u receptor agonists and uses thereof |
| KR101686913B1 (ko) * | 2009-08-13 | 2016-12-16 | 삼성전자주식회사 | 전자기기에서 이벤트 서비스 제공 방법 및 장치 |
| WO2011133750A1 (en) | 2010-04-22 | 2011-10-27 | Janssen Pharmaceutica Nv | Indazole compounds useful as ketohexokinase inhibitors |
| EP2600897A2 (en) | 2010-08-06 | 2013-06-12 | The Regents of the University of Colorado, A Body Corporate | Methods and compositions for the inhibition of fructokinase |
| CN102432598A (zh) * | 2010-09-29 | 2012-05-02 | 江苏恒瑞医药股份有限公司 | 三环化合物、其制备方法及其在医药上的应用 |
| US9371282B2 (en) | 2013-05-17 | 2016-06-21 | Centrexion Therapeutics Corporation | Somatostatin receptor subtype 4 (SSTR4) agonists |
| CN106103718B (zh) | 2014-02-11 | 2021-04-02 | 阿尔尼拉姆医药品有限公司 | 己酮糖激酶(KHK)iRNA组合物及其使用方法 |
| ES2871251T3 (es) * | 2015-12-29 | 2021-10-28 | Pfizer | 3-Azabiciclo[3.1.0]Hexanos sustituidos como inhibidores de la cetohexocinasa |
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