PE20150682A1 - Variantes de inmunoglobulinas y sus usos - Google Patents
Variantes de inmunoglobulinas y sus usosInfo
- Publication number
- PE20150682A1 PE20150682A1 PE2015000431A PE2015000431A PE20150682A1 PE 20150682 A1 PE20150682 A1 PE 20150682A1 PE 2015000431 A PE2015000431 A PE 2015000431A PE 2015000431 A PE2015000431 A PE 2015000431A PE 20150682 A1 PE20150682 A1 PE 20150682A1
- Authority
- PE
- Peru
- Prior art keywords
- immunoglobulin variants
- variants
- immunoglobulin
- lives
- vivo
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 2
- 102000018358 immunoglobulin Human genes 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10508608P | 2008-10-14 | 2008-10-14 | |
| US15213109P | 2009-02-12 | 2009-02-12 | |
| US17176809P | 2009-04-22 | 2009-04-22 | |
| US22051409P | 2009-06-25 | 2009-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20150682A1 true PE20150682A1 (es) | 2015-05-20 |
Family
ID=41571534
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015000431A PE20150682A1 (es) | 2008-10-14 | 2009-10-13 | Variantes de inmunoglobulinas y sus usos |
| PE2011000886A PE20110707A1 (es) | 2008-10-14 | 2009-10-13 | Variantes de inmunoglobulinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000886A PE20110707A1 (es) | 2008-10-14 | 2009-10-13 | Variantes de inmunoglobulinas |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20100098730A1 (fr) |
| EP (2) | EP2352521B1 (fr) |
| JP (2) | JP5913980B2 (fr) |
| KR (3) | KR102100066B1 (fr) |
| CN (3) | CN110317272A (fr) |
| AR (1) | AR073829A1 (fr) |
| AU (1) | AU2009303526B2 (fr) |
| BR (1) | BRPI0914091B1 (fr) |
| CA (1) | CA2739429C (fr) |
| CL (1) | CL2015000148A1 (fr) |
| ES (1) | ES2828721T3 (fr) |
| IL (2) | IL212048B (fr) |
| MX (1) | MX2011004001A (fr) |
| PE (2) | PE20150682A1 (fr) |
| PH (1) | PH12016500081A1 (fr) |
| PL (1) | PL2352521T3 (fr) |
| RU (1) | RU2536937C2 (fr) |
| SG (2) | SG10201605250SA (fr) |
| TW (2) | TWI572359B (fr) |
| WO (1) | WO2010045193A1 (fr) |
| ZA (1) | ZA201102413B (fr) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DK1443961T3 (da) * | 2001-10-25 | 2009-08-24 | Genentech Inc | Glycoprotein-sammensætninger |
| CA2587617C (fr) | 2004-11-12 | 2011-02-01 | Xencor, Inc. | Variants fc presentant une liaison modifiee au fcrn |
| CN101479381B (zh) | 2006-03-31 | 2015-04-29 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| US20080127996A1 (en) * | 2006-12-04 | 2008-06-05 | Weinhold Dennis G | Method and apparatus to remediate an acid and/or liquid spill |
| EP3127921A1 (fr) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Procédé de modification d'un anticorps par point isoélectrique par substitution d'acide aminé dans cdr |
| WO2009041613A1 (fr) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | Région constante d'anticorps modifié |
| US12492253B1 (en) | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| HUE067049T2 (hu) | 2008-04-11 | 2024-09-28 | Chugai Pharmaceutical Co Ltd | Két vagy több antigén-molekulát ismétlõdõen megkötni képes antigénkötõ molekula |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| EP2233500A1 (fr) * | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Variantes Fc optimisées |
| CA2757931C (fr) | 2009-04-07 | 2019-03-26 | Roche Glycart Ag | Anticorps trivalents bispecifiques |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| EP2478013B1 (fr) | 2009-09-16 | 2018-10-24 | F.Hoffmann-La Roche Ag | Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations |
| RU2559542C2 (ru) | 2009-12-23 | 2015-08-10 | Дженентек, Инк. | Антитела против bv8 и их применение |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| TWI667257B (zh) * | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| WO2011133886A2 (fr) | 2010-04-23 | 2011-10-27 | Genentech, Inc. | Production de protéines hétéromultimères |
| BR112013001847A2 (pt) | 2010-08-24 | 2016-05-31 | Hoffmann La Roche | anticorpo biespecífico, método de preparação do anticorpo biespecífico, do anticorpo biespecífico trivalente, métodos e composição farmacêutica |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| EP2655413B1 (fr) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| EP3604330A1 (fr) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Anticorps fc spécifique au fcgammariib |
| JP5768147B2 (ja) | 2011-02-28 | 2015-08-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 一価抗原結合タンパク質 |
| CN103502271B (zh) | 2011-02-28 | 2016-10-26 | 霍夫曼-拉罗奇有限公司 | 抗原结合蛋白 |
| CN105949313B (zh) | 2011-03-29 | 2021-06-15 | 罗切格利卡特公司 | 抗体Fc变体 |
| DK2728002T3 (da) | 2011-06-30 | 2022-04-04 | Chugai Pharmaceutical Co Ltd | Heterodimeriseret polypeptid |
| UA117901C2 (uk) * | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| KR20200120743A (ko) * | 2011-07-06 | 2020-10-21 | 젠맵 비. 브이 | 항체 변이체 및 그의 용도 |
| TW201817745A (zh) * | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
| WO2013047748A1 (fr) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques |
| SG11201401101XA (en) | 2011-09-30 | 2014-08-28 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule for promoting loss of antigens |
| SG11201401100UA (en) | 2011-09-30 | 2014-07-30 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule inducing immune response to target antigen |
| JP6271251B2 (ja) | 2011-10-05 | 2018-01-31 | 中外製薬株式会社 | 糖鎖受容体結合ドメインを含む抗原の血漿中からの消失を促進する抗原結合分子 |
| AU2012323316B2 (en) * | 2011-10-11 | 2017-08-10 | Viela Bio, Inc. | CD40L-specific Tn3-derived scaffolds and methods of use thereof |
| SG10201609301QA (en) | 2011-11-30 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | Drug containing carrier into cell for forming immune complex |
| KR102041412B1 (ko) * | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Fc 단편 유도체 |
| HK1201296A1 (en) | 2012-02-09 | 2015-08-28 | 中外制药株式会社 | Modified fc region of antibody |
| MX2014009565A (es) | 2012-02-10 | 2014-11-10 | Genentech Inc | Anticuerpos monocatenarios y otros heteromultimeros. |
| ES2676031T3 (es) | 2012-02-15 | 2018-07-16 | F. Hoffmann-La Roche Ag | Cromatografía de afinidad basada en el receptor Fc |
| EP3738980A1 (fr) | 2012-02-24 | 2020-11-18 | Chugai Seiyaku Kabushiki Kaisha | Molécule de liaison d'antigène destinée à favoriser la disparition d'antigène via le récepteur fc riib |
| ES2856272T3 (es) | 2012-05-30 | 2021-09-27 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígenos para eliminar antígenos agregados |
| AU2013268418B2 (en) | 2012-05-30 | 2017-12-07 | Chugai Seiyaku Kabushiki Kaisha | Target-tissue-specific antigen-binding molecule |
| RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
| ES2597228T3 (es) | 2012-06-27 | 2017-01-17 | F. Hoffmann-La Roche Ag | Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas |
| EP3632462A1 (fr) * | 2012-07-06 | 2020-04-08 | Genmab B.V. | Protéine dimérique ayant des mutations triples |
| JP6514103B2 (ja) * | 2012-07-06 | 2019-05-15 | ゲンマブ ビー.ブイ. | 三重変異を有する二量体タンパク質 |
| WO2014009465A1 (fr) | 2012-07-13 | 2014-01-16 | Roche Glycart Ag | Anticorps bispécifiques anti-vegf/anti-ang-2 et leur utilisation dans le cadre du traitement de pathologies vasculaires oculaires |
| EP3597747B1 (fr) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Anticorps fc spécifiques fcgammarii de souris |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| EA201500741A1 (ru) * | 2013-01-10 | 2016-01-29 | Генмаб Б.В. | ВАРИАНТЫ Fc-ОБЛАСТИ IGG1 ЧЕЛОВЕКА И ИХ ПРИМЕНЕНИЕ |
| EP2968495B1 (fr) * | 2013-03-15 | 2019-07-03 | Daniel J. Capon | Immunoglobuline hybride contenant une liaison non peptidique |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Fc영역 개변체 |
| KR102266819B1 (ko) * | 2013-04-29 | 2021-06-18 | 에프. 호프만-라 로슈 아게 | Fc-수용체 결합 개질된 비대칭 항체 및 이의 사용 방법 |
| WO2014177460A1 (fr) | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Anticorps modifiés se liant au fcrn humain et procédés d'utilisation |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| CN105916880B (zh) | 2014-01-15 | 2020-01-17 | 豪夫迈·罗氏有限公司 | 具有改善的蛋白A结合作用的Fc区变体 |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| MX377605B (es) | 2014-03-14 | 2025-03-10 | Daniel J Capon | Inmunoglobulina híbrida conteniendo un enlace no-peptidílico. |
| WO2015140126A1 (fr) | 2014-03-21 | 2015-09-24 | F. Hoffmann-La Roche Ag | Prédiction in vitro de demi-vie in vivo d'anticorps |
| WO2015171822A1 (fr) | 2014-05-06 | 2015-11-12 | Genentech, Inc. | Production de protéines hétéromultimères au moyen de cellules mammaliennes |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20170078677A (ko) * | 2014-11-06 | 2017-07-07 | 에프. 호프만-라 로슈 아게 | Fcrn-결합이 개질된 fc-영역 변이체 및 이의 사용 방법 |
| WO2016087416A1 (fr) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Anticorps multispécifiques |
| TWI779010B (zh) | 2014-12-19 | 2022-10-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
| CN114773470A (zh) * | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| KR102709693B1 (ko) | 2015-12-18 | 2024-09-24 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| WO2017110981A1 (fr) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anticorps anti-myostatine et procédés d'utilisation |
| SG11201805420SA (en) | 2015-12-30 | 2018-07-30 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| PT3430039T (pt) * | 2016-03-14 | 2026-01-16 | Univ Oslo | Imunoglobulinas manipuladas com ligação a fcrn alterada |
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