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PE20150682A1 - Variantes de inmunoglobulinas y sus usos - Google Patents

Variantes de inmunoglobulinas y sus usos

Info

Publication number
PE20150682A1
PE20150682A1 PE2015000431A PE2015000431A PE20150682A1 PE 20150682 A1 PE20150682 A1 PE 20150682A1 PE 2015000431 A PE2015000431 A PE 2015000431A PE 2015000431 A PE2015000431 A PE 2015000431A PE 20150682 A1 PE20150682 A1 PE 20150682A1
Authority
PE
Peru
Prior art keywords
immunoglobulin variants
variants
immunoglobulin
lives
vivo
Prior art date
Application number
PE2015000431A
Other languages
English (en)
Spanish (es)
Inventor
Lisa A Damico
Napoleone Ferrara
Henry B Lowman
Yu-Ju G Meng
Yik Andy Yeung
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41571534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20150682(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20150682A1 publication Critical patent/PE20150682A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PE2015000431A 2008-10-14 2009-10-13 Variantes de inmunoglobulinas y sus usos PE20150682A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10508608P 2008-10-14 2008-10-14
US15213109P 2009-02-12 2009-02-12
US17176809P 2009-04-22 2009-04-22
US22051409P 2009-06-25 2009-06-25

Publications (1)

Publication Number Publication Date
PE20150682A1 true PE20150682A1 (es) 2015-05-20

Family

ID=41571534

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2015000431A PE20150682A1 (es) 2008-10-14 2009-10-13 Variantes de inmunoglobulinas y sus usos
PE2011000886A PE20110707A1 (es) 2008-10-14 2009-10-13 Variantes de inmunoglobulinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011000886A PE20110707A1 (es) 2008-10-14 2009-10-13 Variantes de inmunoglobulinas

Country Status (21)

Country Link
US (3) US20100098730A1 (fr)
EP (2) EP2352521B1 (fr)
JP (2) JP5913980B2 (fr)
KR (3) KR102100066B1 (fr)
CN (3) CN110317272A (fr)
AR (1) AR073829A1 (fr)
AU (1) AU2009303526B2 (fr)
BR (1) BRPI0914091B1 (fr)
CA (1) CA2739429C (fr)
CL (1) CL2015000148A1 (fr)
ES (1) ES2828721T3 (fr)
IL (2) IL212048B (fr)
MX (1) MX2011004001A (fr)
PE (2) PE20150682A1 (fr)
PH (1) PH12016500081A1 (fr)
PL (1) PL2352521T3 (fr)
RU (1) RU2536937C2 (fr)
SG (2) SG10201605250SA (fr)
TW (2) TWI572359B (fr)
WO (1) WO2010045193A1 (fr)
ZA (1) ZA201102413B (fr)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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CN102245208B (zh) 2016-03-16
AU2009303526B2 (en) 2015-01-15
CN104447990A (zh) 2015-03-25
ZA201102413B (en) 2012-06-27
JP6122072B2 (ja) 2017-04-26
CN102245208A (zh) 2011-11-16
TW201542228A (zh) 2015-11-16
CN110317272A (zh) 2019-10-11
PL2352521T3 (pl) 2021-03-08
JP2012505833A (ja) 2012-03-08
PH12016500081B1 (en) 2017-01-16
CN104447990B (zh) 2019-07-19
HK1163550A1 (zh) 2012-09-14
US20210002359A1 (en) 2021-01-07
KR101834999B1 (ko) 2018-03-06
KR20180027609A (ko) 2018-03-14
BRPI0914091B1 (pt) 2022-05-10
ES2828721T3 (es) 2021-05-27
US20100098730A1 (en) 2010-04-22
TWI572357B (zh) 2017-03-01
IL212048B (en) 2020-02-27
EP2352521B1 (fr) 2020-09-16
US20140294810A1 (en) 2014-10-02
JP5913980B2 (ja) 2016-05-11
WO2010045193A1 (fr) 2010-04-22
AU2009303526A1 (en) 2010-04-22
IL212048A0 (en) 2011-06-30
EP3524620A1 (fr) 2019-08-14
PH12016500081A1 (en) 2017-01-16
SG195558A1 (en) 2013-12-30
BRPI0914091A2 (pt) 2016-09-27
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HK1209130A1 (en) 2016-03-24
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PE20110707A1 (es) 2011-10-11
KR102100066B1 (ko) 2020-04-10
TWI572359B (zh) 2017-03-01
IL264138A (en) 2019-02-28
TW201023884A (en) 2010-07-01
RU2536937C2 (ru) 2014-12-27
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