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PE20141172A1 - Composiciones de nucleasa terapeuticas y metodos - Google Patents

Composiciones de nucleasa terapeuticas y metodos

Info

Publication number
PE20141172A1
PE20141172A1 PE2013002425A PE2013002425A PE20141172A1 PE 20141172 A1 PE20141172 A1 PE 20141172A1 PE 2013002425 A PE2013002425 A PE 2013002425A PE 2013002425 A PE2013002425 A PE 2013002425A PE 20141172 A1 PE20141172 A1 PE 20141172A1
Authority
PE
Peru
Prior art keywords
domain
nucleasa
methods
therapeutic compositions
dnase
Prior art date
Application number
PE2013002425A
Other languages
English (en)
Inventor
Jeffrey A Ledbetter
Martha Hayden-Ledbetter
Keith Elkon
Xizhang Sun
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of PE20141172A1 publication Critical patent/PE20141172A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)

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Abstract

SE REFIERE A UNA MOLECULA DE NUCLEASA HIBRIDA QUE COMPRENDE: a) UN PRIMER DOMINIO DE NUCLEASA, QUE PRESENTA UNA RNASA A PANCREATICA HUMANA Y DNASA QUE SE SELECCIONA DEL GRUPO FORMADO POR UNA DNASA HUMANA DE TIPO 1, UNA DNASA HUMANA IL3, TREXI HUMANA ; Y b) UN DOMINIO FC MODIFICADO, DONDE EL PRIMER DOMINIO DE NUCLEASA ESTA ACOPLADO OPERATIVAMENTE AL DOMINIO FC, QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS QUE TIENE LAS MUTACIONES P238S, P331, SCCC, ENTRE OTROS. DICHA MOLECULA COMPRENDE UNA SECUENCIA DE AMINOACIDOS EN SEQ ID NO: 62,64, 78, 80, ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES.
PE2013002425A 2011-04-29 2012-04-27 Composiciones de nucleasa terapeuticas y metodos PE20141172A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480961P 2011-04-29 2011-04-29
US201261617241P 2012-03-29 2012-03-29

Publications (1)

Publication Number Publication Date
PE20141172A1 true PE20141172A1 (es) 2014-09-22

Family

ID=47073103

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002425A PE20141172A1 (es) 2011-04-29 2012-04-27 Composiciones de nucleasa terapeuticas y metodos

Country Status (28)

Country Link
US (5) US10202588B2 (es)
EP (2) EP2704737B1 (es)
JP (7) JP6063450B2 (es)
KR (6) KR20250037576A (es)
CN (2) CN103930127B (es)
AU (5) AU2012249360B2 (es)
BR (1) BR112013027547B1 (es)
CA (1) CA2834626A1 (es)
CL (1) CL2013003123A1 (es)
CO (1) CO6811815A2 (es)
CR (1) CR20130598A (es)
DK (1) DK2704737T3 (es)
DO (1) DOP2013000250A (es)
EA (1) EA201391585A1 (es)
EC (1) ECSP13013060A (es)
ES (1) ES2666303T3 (es)
HR (1) HRP20180564T1 (es)
HU (1) HUE038759T2 (es)
IL (5) IL313299A (es)
LT (1) LT2704737T (es)
MX (3) MX389061B (es)
NZ (1) NZ616989A (es)
PE (1) PE20141172A1 (es)
PH (1) PH12013502441B1 (es)
PL (1) PL2704737T3 (es)
SG (2) SG194680A1 (es)
SI (1) SI2704737T1 (es)
WO (1) WO2012149440A2 (es)

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KR102777015B1 (ko) 2017-08-22 2025-03-10 사나바이오, 엘엘씨 가용성 인터페론 수용체 및 그의 용도
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JP2020136505A (ja) 2019-02-20 2020-08-31 株式会社Ｊｏｌｅｄ 半導体装置および表示装置
IL294114A (en) * 2020-01-11 2022-08-01 Univ Yale Preparations and methods for the treatment, improvement and/or prevention of diseases or disorders caused by or related to dnase1 and/or dnase1l3
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