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PE20141019A1 - Nuevos inmunoconjugados - Google Patents

Nuevos inmunoconjugados

Info

Publication number
PE20141019A1
PE20141019A1 PE2013002424A PE2013002424A PE20141019A1 PE 20141019 A1 PE20141019 A1 PE 20141019A1 PE 2013002424 A PE2013002424 A PE 2013002424A PE 2013002424 A PE2013002424 A PE 2013002424A PE 20141019 A1 PE20141019 A1 PE 20141019A1
Authority
PE
Peru
Prior art keywords
antigen
domain
refers
immunoconjugates
new
Prior art date
Application number
PE2013002424A
Other languages
English (en)
Inventor
Oliver Ast
Peter Bruenker
Thomas U Hofer
Ralf Hosse
Christian Klein
Ekkehard Moessner
Pablo Umana
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46022216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141019(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of PE20141019A1 publication Critical patent/PE20141019A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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Abstract

SE REFIERE A UN INMUNOCONJUGADO QUE COMPRENDE: a) LA PRIMERA Y SEGUNDA PORCION DE UNION A ANTIGENO, QUE SE DIRIGEN A UN ANTIGENO SELECCIONADO DEL GRUPO DE LA PROTEINA DE ACTIVACION DE FIBROBLASTOS (FAP), DOMINIO A1 DE LA TENASCINA-C (TNC A1), ANTIGENO CARCINOEMBRIONARIO (CEA), ENTRE OTROS; b) UN DOMINIO FC QUE CONSTA DE DOS SUBUNIDADES, QUE COMPRENDE LAS SUSTITUCIONES DE AMINOACIDOS L234A, L235A Y P329G ; c) UNA PORCION EFECTORA QUE ES UNA CITOQUINA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, QUE ES UTIL PARA EL TRATAMIENTO DE UN TRASTORNO INFLAMATORIO
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