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PE20121507A1 - Derivados de (heterociclo-piperidina condensada)-(piperazinil)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona como inhibidores de p75 - Google Patents

Derivados de (heterociclo-piperidina condensada)-(piperazinil)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona como inhibidores de p75

Info

Publication number
PE20121507A1
PE20121507A1 PE2012000829A PE2012000829A PE20121507A1 PE 20121507 A1 PE20121507 A1 PE 20121507A1 PE 2012000829 A PE2012000829 A PE 2012000829A PE 2012000829 A PE2012000829 A PE 2012000829A PE 20121507 A1 PE20121507 A1 PE 20121507A1
Authority
PE
Peru
Prior art keywords
condensada
piperazinil
formula
pirrolidada
inhibitores
Prior art date
Application number
PE2012000829A
Other languages
English (en)
Inventor
Marco Baroni
Françoise Bono
Sandrine Delbary-Gossart
Valentina Vercesi
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PE20121507A1 publication Critical patent/PE20121507A1/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A ES UN GRUPO DE FORMULA (a); n ES 1 O 2; m ES 0 O 1; W ES UN HETEROCICLO NITROGENADO TAL COMO (b), ENTRE OTROS; R2 ES UN GRUPO DE FORMULA (c), ENTRE OTROS; X, X1 Y X2 SON O, C, N O S DONDE AL MENOS UNO DE ELLOS ES DIFERENTE DE UN ATOMO DE CARBONO; R1 Y R SON INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS; Y ES C, N, ENTRE OTROS; R7 Y R8 SON INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS. R5 Y R6 SON H O ALQUILO C1-6; 1-2 REPRESENTA 1 Ò 2. SON COMPUESTOS PREFERIDOS: 1-(6,7-DIHIDRO-4H-TIENO[3,2-c]PIRIDIN-5-IL)-2-[8-(5-FLUORO-PIRIMIDIN-2-IL)-3,8-DIAZA-BICICLO[3.2.1]OCT-3-IL]-ETANONA; ACIDO 6-{(3S,5R)-3,5-DIMETIL-4-[2-OXO-2-(2-FENIL-6,7-DIHIDRO-4H-TIAZOLO[5,4-c]PIRIDIN-5-IL)-ETIL]-PIPERAZIN-1-IL}-NICOTINICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEIMIDENTO DE PREPARACION. DICHO COMPUESTO ES INHIBIDOR DEL RECEPTOR P75NTR DE LAS NEUROTROFINAS, SIENDO UTIL PARA EL TRATAMIENTO DE ENFERMEDADES TAL COMO ALZHEIMER, DEPRESION, ESQUIZOFRENIA, ESCLEROSIS MULTIPLE
PE2012000829A 2009-12-14 2010-12-13 Derivados de (heterociclo-piperidina condensada)-(piperazinil)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona como inhibidores de p75 PE20121507A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0906023A FR2953839A1 (fr) 2009-12-14 2009-12-14 Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75

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PE20121507A1 true PE20121507A1 (es) 2012-11-24

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PE2012000829A PE20121507A1 (es) 2009-12-14 2010-12-13 Derivados de (heterociclo-piperidina condensada)-(piperazinil)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona como inhibidores de p75

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
EP2606894A1 (en) * 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
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