PE20121437A1 - Compuestos de espiropiperidina y uso farmaceutico de los mismos para el tratamiento de diabetes - Google Patents
Compuestos de espiropiperidina y uso farmaceutico de los mismos para el tratamiento de diabetesInfo
- Publication number
- PE20121437A1 PE20121437A1 PE2012000492A PE2012000492A PE20121437A1 PE 20121437 A1 PE20121437 A1 PE 20121437A1 PE 2012000492 A PE2012000492 A PE 2012000492A PE 2012000492 A PE2012000492 A PE 2012000492A PE 20121437 A1 PE20121437 A1 PE 20121437A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- diabetes
- treatment
- phenyl
- pharmaceutical use
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- -1 SPIROPIPERIDINE COMPOUND Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000006519 CCH3 Chemical group 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE ESPIROPIPERIDINA DE FORMULA (I) DONDE: R1 ES H, F Y CLORO; R2 ES H, ALQUILO C1-3, CF3, OCH3, F Y CLORO; R3 ES H Y ALQUILO C1-3; R4 Y R4a SON INDEPENDIENTEMENTE H, OCH3, ALQUILO C1-3, CF3 Y FLUOR; R5 ES H O C?CCH3; X ES CH(R3)CH2-, -C(R3)=CH-, -N(R7)CH2- Y -C(O)CH2-; R7 ES H, ALQUILO C1-3 Y FENILO; SON COMPUESTOS PREFERIDOS: ACIDO (3S)-3-(4-{[4-(1'H-ESPIRO[INDEN-1,4'-PIPERIDIN]-1'-ILMETIL)BENCIL]OXI}FENIL)HEX-4-INOICO; ACIDO (3S)-3-[4-({4-[(1-METIL-1,2,-DIHIDRO-1'H-ESPIRO[INDOL-3,4'-PIPERIDIN]-1'-IL)METIL]BENCIL}OXI)FENIL]HEX-4-INOICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES MODULADOR DEL RECEPTOR 40 ACOPLADO A LA PROTEINA G (RPG-40), SIENDO UTIL EN EL TRATAMIENTO DE LA DIABETES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25183909P | 2009-10-15 | 2009-10-15 | |
| US30333410P | 2010-02-11 | 2010-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121437A1 true PE20121437A1 (es) | 2012-10-26 |
Family
ID=43719548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000492A PE20121437A1 (es) | 2009-10-15 | 2010-10-11 | Compuestos de espiropiperidina y uso farmaceutico de los mismos para el tratamiento de diabetes |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8383642B2 (es) |
| EP (1) | EP2488500A1 (es) |
| JP (1) | JP2013508279A (es) |
| KR (1) | KR20120051777A (es) |
| CN (1) | CN102574807A (es) |
| AR (1) | AR078522A1 (es) |
| AU (1) | AU2010307094A1 (es) |
| BR (1) | BR112012008889A2 (es) |
| CA (1) | CA2777775A1 (es) |
| CL (1) | CL2012000921A1 (es) |
| CO (1) | CO6531458A2 (es) |
| CR (1) | CR20120177A (es) |
| DO (1) | DOP2012000105A (es) |
| EA (1) | EA201270560A1 (es) |
| EC (1) | ECSP12011799A (es) |
| IL (1) | IL218344A0 (es) |
| MA (1) | MA33662B1 (es) |
| MX (1) | MX2012004420A (es) |
| NZ (1) | NZ598972A (es) |
| PE (1) | PE20121437A1 (es) |
| PH (1) | PH12012500705A1 (es) |
| TN (1) | TN2012000152A1 (es) |
| TW (1) | TW201124415A (es) |
| WO (1) | WO2011046851A1 (es) |
| ZA (1) | ZA201202560B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2411395T1 (sl) | 2009-03-23 | 2013-07-31 | Glenmark Pharmaceuticals S.A. | Furopirimidindionski derivati kot TRPA1 modulatorji |
| EP2411393B1 (en) | 2009-03-23 | 2014-01-22 | Glenmark Pharmaceuticals S.A. | Fused pyrimidine-dione derivatives as trpa1 modulators |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| CN102712610B (zh) | 2009-12-25 | 2015-03-04 | 持田制药株式会社 | 新的3-羟基-5-芳基异噻唑衍生物 |
| WO2012046869A1 (ja) | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
| CA2829351A1 (en) | 2011-03-11 | 2012-09-20 | Intercontinental Great Brands Llc | System and method of forming multilayer confectionery |
| CN105153146A (zh) | 2011-04-27 | 2015-12-16 | 持田制药株式会社 | 新的3-羟基异噻唑1-氧化物衍生物 |
| WO2012147516A1 (ja) | 2011-04-28 | 2012-11-01 | 持田製薬株式会社 | 環状アミド誘導体 |
| AR087451A1 (es) * | 2011-08-17 | 2014-03-26 | Lilly Co Eli | Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes |
| WO2013139341A1 (en) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Gpr120 receptor modulators |
| WO2013185766A1 (en) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Gpr120 receptor modulators |
| US9133163B2 (en) | 2012-11-16 | 2015-09-15 | Bristol-Myers Squibb Company | Dihydropyrazole GPR40 modulators |
| KR101569522B1 (ko) * | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| EP3068788A1 (en) | 2013-11-14 | 2016-09-21 | Cadila Healthcare Limited | Novel heterocyclic compounds |
| US20150351889A1 (en) | 2014-06-05 | 2015-12-10 | Vivex Biomedical Inc. | Dynamic Biometric Mesh |
| MX387086B (es) * | 2014-10-17 | 2025-03-19 | Hyundai Pharm Co Ltd | Preparacion compuesta, que contiene derivado novedoso de acido 3-(4-(benciloxi)fenil)hex-4-inoico y otro ingrediente activo, para prevenir o tratar enfermedades metabolicas |
| CN109666027A (zh) * | 2017-10-17 | 2019-04-23 | 中国科学院上海药物研究所 | 一类酰胺结构的gpr40激动剂化合物及其用途 |
| DK3737470T5 (da) | 2018-01-08 | 2024-05-27 | Celon Pharma Sa | 3-phenyl-4-hexynsyrederivater som gpr40-agonister |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3781556B1 (en) | 2018-04-19 | 2025-06-18 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| PL3820572T3 (pl) | 2018-07-13 | 2024-02-26 | Gilead Sciences, Inc. | Inhibitory pd-1/pd-l1 |
| CA3117199C (en) | 2018-10-24 | 2024-03-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CN114945560B (zh) | 2019-10-07 | 2024-08-13 | 卡尔优普公司 | Gpr119激动剂 |
| CN115667277A (zh) | 2020-02-28 | 2023-01-31 | 卡尔优普公司 | Gpr40激动剂 |
| UY39222A (es) | 2020-05-19 | 2021-11-30 | Kallyope Inc | Activadores de la ampk |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1385514T1 (sl) * | 2001-04-18 | 2009-04-30 | Euro Celtique Sa | Spiroindenske in spiroindanske spojine |
| EP1613601A4 (en) * | 2003-04-04 | 2007-05-02 | Merck & Co Inc | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS |
| US7504506B2 (en) * | 2003-11-04 | 2009-03-17 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| BRPI0508098A (pt) | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
| EP1731505B1 (en) * | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| EP1924546A1 (en) * | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| EP2061760A1 (en) | 2006-09-07 | 2009-05-27 | Amgen, Inc | Benzo-fused compounds for use in treating metabolic disorders |
| SI2202216T1 (sl) * | 2007-10-26 | 2012-10-30 | Japan Tobacco Inc | Spiro obročna spojina in njena uporaba za medicinske namene |
| JP2011504499A (ja) * | 2007-11-21 | 2011-02-10 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリプターゼ阻害剤として使用するためのスピロピペリジン |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
-
2010
- 2010-10-04 AR ARP100103604A patent/AR078522A1/es not_active Application Discontinuation
- 2010-10-06 TW TW099134098A patent/TW201124415A/zh unknown
- 2010-10-11 WO PCT/US2010/052126 patent/WO2011046851A1/en not_active Ceased
- 2010-10-11 EA EA201270560A patent/EA201270560A1/ru unknown
- 2010-10-11 BR BR112012008889A patent/BR112012008889A2/pt not_active IP Right Cessation
- 2010-10-11 KR KR1020127009501A patent/KR20120051777A/ko not_active Ceased
- 2010-10-11 AU AU2010307094A patent/AU2010307094A1/en not_active Abandoned
- 2010-10-11 MX MX2012004420A patent/MX2012004420A/es not_active Application Discontinuation
- 2010-10-11 CA CA2777775A patent/CA2777775A1/en not_active Abandoned
- 2010-10-11 NZ NZ598972A patent/NZ598972A/xx not_active IP Right Cessation
- 2010-10-11 EP EP10793349A patent/EP2488500A1/en not_active Withdrawn
- 2010-10-11 PE PE2012000492A patent/PE20121437A1/es not_active Application Discontinuation
- 2010-10-11 PH PH1/2012/500705A patent/PH12012500705A1/en unknown
- 2010-10-11 US US12/901,597 patent/US8383642B2/en not_active Expired - Fee Related
- 2010-10-11 JP JP2012534259A patent/JP2013508279A/ja not_active Withdrawn
- 2010-10-11 CN CN2010800462763A patent/CN102574807A/zh active Pending
-
2012
- 2012-02-27 IL IL218344A patent/IL218344A0/en unknown
- 2012-04-02 TN TNP2012000152A patent/TN2012000152A1/en unknown
- 2012-04-09 MA MA34760A patent/MA33662B1/fr unknown
- 2012-04-10 ZA ZA2012/02560A patent/ZA201202560B/en unknown
- 2012-04-12 CR CR20120177A patent/CR20120177A/es not_active Application Discontinuation
- 2012-04-12 CL CL2012000921A patent/CL2012000921A1/es unknown
- 2012-04-13 DO DO2012000105A patent/DOP2012000105A/es unknown
- 2012-04-13 EC ECSP12011799 patent/ECSP12011799A/es unknown
- 2012-04-20 CO CO12065315A patent/CO6531458A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102574807A (zh) | 2012-07-11 |
| BR112012008889A2 (pt) | 2019-09-24 |
| TW201124415A (en) | 2011-07-16 |
| WO2011046851A1 (en) | 2011-04-21 |
| ZA201202560B (en) | 2013-09-25 |
| US8383642B2 (en) | 2013-02-26 |
| MA33662B1 (fr) | 2012-10-01 |
| DOP2012000105A (es) | 2013-01-31 |
| EP2488500A1 (en) | 2012-08-22 |
| CA2777775A1 (en) | 2011-04-21 |
| TN2012000152A1 (en) | 2013-12-12 |
| CL2012000921A1 (es) | 2012-09-14 |
| MX2012004420A (es) | 2012-05-08 |
| US20110092531A1 (en) | 2011-04-21 |
| IL218344A0 (en) | 2012-04-30 |
| AR078522A1 (es) | 2011-11-16 |
| KR20120051777A (ko) | 2012-05-22 |
| NZ598972A (en) | 2013-06-28 |
| ECSP12011799A (es) | 2012-07-31 |
| EA201270560A1 (ru) | 2012-09-28 |
| JP2013508279A (ja) | 2013-03-07 |
| CR20120177A (es) | 2012-06-06 |
| PH12012500705A1 (en) | 2012-10-29 |
| CO6531458A2 (es) | 2012-09-28 |
| AU2010307094A1 (en) | 2012-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |