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MX2012004420A - Compuestos de espiropiperidino y uso farmaceutico de los mismos para tratar diabetes. - Google Patents

Compuestos de espiropiperidino y uso farmaceutico de los mismos para tratar diabetes.

Info

Publication number
MX2012004420A
MX2012004420A MX2012004420A MX2012004420A MX2012004420A MX 2012004420 A MX2012004420 A MX 2012004420A MX 2012004420 A MX2012004420 A MX 2012004420A MX 2012004420 A MX2012004420 A MX 2012004420A MX 2012004420 A MX2012004420 A MX 2012004420A
Authority
MX
Mexico
Prior art keywords
treating diabetes
pharmaceutical use
spiropiperidine compounds
spiropiperidine
compounds
Prior art date
Application number
MX2012004420A
Other languages
English (en)
Inventor
Chafiq Hamdouchi
Jayana Pankaj Lineswala
Pranab Maiti
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43719548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012004420(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2012004420A publication Critical patent/MX2012004420A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la fórmula: (1) o una sal del mismo farmacéuticamente aceptable así como también una composición farmacéutica, y un método para tratar diabetes (ver formula).
MX2012004420A 2009-10-15 2010-10-11 Compuestos de espiropiperidino y uso farmaceutico de los mismos para tratar diabetes. MX2012004420A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25183909P 2009-10-15 2009-10-15
US30333410P 2010-02-11 2010-02-11
PCT/US2010/052126 WO2011046851A1 (en) 2009-10-15 2010-10-11 Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes

Publications (1)

Publication Number Publication Date
MX2012004420A true MX2012004420A (es) 2012-05-08

Family

ID=43719548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004420A MX2012004420A (es) 2009-10-15 2010-10-11 Compuestos de espiropiperidino y uso farmaceutico de los mismos para tratar diabetes.

Country Status (25)

Country Link
US (1) US8383642B2 (es)
EP (1) EP2488500A1 (es)
JP (1) JP2013508279A (es)
KR (1) KR20120051777A (es)
CN (1) CN102574807A (es)
AR (1) AR078522A1 (es)
AU (1) AU2010307094A1 (es)
BR (1) BR112012008889A2 (es)
CA (1) CA2777775A1 (es)
CL (1) CL2012000921A1 (es)
CO (1) CO6531458A2 (es)
CR (1) CR20120177A (es)
DO (1) DOP2012000105A (es)
EA (1) EA201270560A1 (es)
EC (1) ECSP12011799A (es)
IL (1) IL218344A0 (es)
MA (1) MA33662B1 (es)
MX (1) MX2012004420A (es)
NZ (1) NZ598972A (es)
PE (1) PE20121437A1 (es)
PH (1) PH12012500705A1 (es)
TN (1) TN2012000152A1 (es)
TW (1) TW201124415A (es)
WO (1) WO2011046851A1 (es)
ZA (1) ZA201202560B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2411395T1 (sl) 2009-03-23 2013-07-31 Glenmark Pharmaceuticals S.A. Furopirimidindionski derivati kot TRPA1 modulatorji
EP2411393B1 (en) 2009-03-23 2014-01-22 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as trpa1 modulators
AR078948A1 (es) 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
CN102712610B (zh) 2009-12-25 2015-03-04 持田制药株式会社 新的3-羟基-5-芳基异噻唑衍生物
WO2012046869A1 (ja) 2010-10-08 2012-04-12 持田製薬株式会社 環状アミド誘導体
CA2829351A1 (en) 2011-03-11 2012-09-20 Intercontinental Great Brands Llc System and method of forming multilayer confectionery
CN105153146A (zh) 2011-04-27 2015-12-16 持田制药株式会社 新的3-羟基异噻唑1-氧化物衍生物
WO2012147516A1 (ja) 2011-04-28 2012-11-01 持田製薬株式会社 環状アミド誘導体
AR087451A1 (es) * 2011-08-17 2014-03-26 Lilly Co Eli Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes
WO2013139341A1 (en) * 2012-03-20 2013-09-26 Syddansk Universitet Gpr120 receptor modulators
WO2013185766A1 (en) * 2012-06-15 2013-12-19 Syddansk Universitet Gpr120 receptor modulators
US9133163B2 (en) 2012-11-16 2015-09-15 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
KR101569522B1 (ko) * 2013-04-18 2015-11-17 현대약품 주식회사 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
EP3068788A1 (en) 2013-11-14 2016-09-21 Cadila Healthcare Limited Novel heterocyclic compounds
US20150351889A1 (en) 2014-06-05 2015-12-10 Vivex Biomedical Inc. Dynamic Biometric Mesh
MX387086B (es) * 2014-10-17 2025-03-19 Hyundai Pharm Co Ltd Preparacion compuesta, que contiene derivado novedoso de acido 3-(4-(benciloxi)fenil)hex-4-inoico y otro ingrediente activo, para prevenir o tratar enfermedades metabolicas
CN109666027A (zh) * 2017-10-17 2019-04-23 中国科学院上海药物研究所 一类酰胺结构的gpr40激动剂化合物及其用途
DK3737470T5 (da) 2018-01-08 2024-05-27 Celon Pharma Sa 3-phenyl-4-hexynsyrederivater som gpr40-agonister
KR102708681B1 (ko) 2018-02-13 2024-09-26 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP3781556B1 (en) 2018-04-19 2025-06-18 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
PL3820572T3 (pl) 2018-07-13 2024-02-26 Gilead Sciences, Inc. Inhibitory pd-1/pd-l1
CA3117199C (en) 2018-10-24 2024-03-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN114945560B (zh) 2019-10-07 2024-08-13 卡尔优普公司 Gpr119激动剂
CN115667277A (zh) 2020-02-28 2023-01-31 卡尔优普公司 Gpr40激动剂
UY39222A (es) 2020-05-19 2021-11-30 Kallyope Inc Activadores de la ampk
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1385514T1 (sl) * 2001-04-18 2009-04-30 Euro Celtique Sa Spiroindenske in spiroindanske spojine
EP1613601A4 (en) * 2003-04-04 2007-05-02 Merck & Co Inc ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
US7504506B2 (en) * 2003-11-04 2009-03-17 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
WO2005051890A1 (en) 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
BRPI0508098A (pt) 2004-02-27 2007-07-17 Amgen Inc compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos
EP1731505B1 (en) * 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
EP1924546A1 (en) * 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EP2061760A1 (en) 2006-09-07 2009-05-27 Amgen, Inc Benzo-fused compounds for use in treating metabolic disorders
SI2202216T1 (sl) * 2007-10-26 2012-10-30 Japan Tobacco Inc Spiro obročna spojina in njena uporaba za medicinske namene
JP2011504499A (ja) * 2007-11-21 2011-02-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリプターゼ阻害剤として使用するためのスピロピペリジン
AR078948A1 (es) 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes

Also Published As

Publication number Publication date
CN102574807A (zh) 2012-07-11
BR112012008889A2 (pt) 2019-09-24
PE20121437A1 (es) 2012-10-26
TW201124415A (en) 2011-07-16
WO2011046851A1 (en) 2011-04-21
ZA201202560B (en) 2013-09-25
US8383642B2 (en) 2013-02-26
MA33662B1 (fr) 2012-10-01
DOP2012000105A (es) 2013-01-31
EP2488500A1 (en) 2012-08-22
CA2777775A1 (en) 2011-04-21
TN2012000152A1 (en) 2013-12-12
CL2012000921A1 (es) 2012-09-14
US20110092531A1 (en) 2011-04-21
IL218344A0 (en) 2012-04-30
AR078522A1 (es) 2011-11-16
KR20120051777A (ko) 2012-05-22
NZ598972A (en) 2013-06-28
ECSP12011799A (es) 2012-07-31
EA201270560A1 (ru) 2012-09-28
JP2013508279A (ja) 2013-03-07
CR20120177A (es) 2012-06-06
PH12012500705A1 (en) 2012-10-29
CO6531458A2 (es) 2012-09-28
AU2010307094A1 (en) 2012-04-19

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