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PE20120650A1 - Acetamidas sustituidas por n-(hetero)-arilo y 2-(hetero)-arilo, como moduladores de la senalizacion de wnt - Google Patents

Acetamidas sustituidas por n-(hetero)-arilo y 2-(hetero)-arilo, como moduladores de la senalizacion de wnt

Info

Publication number
PE20120650A1
PE20120650A1 PE2011001579A PE2011001579A PE20120650A1 PE 20120650 A1 PE20120650 A1 PE 20120650A1 PE 2011001579 A PE2011001579 A PE 2011001579A PE 2011001579 A PE2011001579 A PE 2011001579A PE 20120650 A1 PE20120650 A1 PE 20120650A1
Authority
PE
Peru
Prior art keywords
phenyl
methyl
aryl
straight
pyridin
Prior art date
Application number
PE2011001579A
Other languages
English (en)
Inventor
Dai Cheng
Guobao Zhang
Dong Han
Wenqi Gao
Shifeng Pan
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42112245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120650(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20120650A1 publication Critical patent/PE20120650A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: X1, X2, X3 Y X4 SON N O CR7; X5, X6, X7 Y X8 SON N O CH; X9 ES N O CH; Z ES FENILO, PIRAZINILO, PIRIDINILO, ENTRE OTROS; R1, R2 Y R3 SON CADA UNO H; m ES 1; R4 ES H, HALOGENO, DIFLUORO-METILO, TRIFLUORO-METILO Y METILO; R7 ES H, HALOGENO, CIANO, METILO Y TRIFLUORO-METILO; E ES FENILO. SON COMPUESTOS PREFERIDOS: N-(6-METOXI-BENZO-[d]-TIAZOL-2-IL)-2-(3-(PIRIDIN-4-IL)-FENIL)-ACETAMIDA; 2-(3-(2-METOXI-PIRIDIN-4-IL)-FENIL)-N-(6-FENIL-PIRIDIN-3-IL)-ACETAMIDA; 2-(4-CIANO-3-(2-METIL-PIPERIDIN-4-IL)-FENIL)-N-(6-FENIL-PIRIDIN-3-IL)-ACETAMIDA; 1-OXIDO DE 2-(2-(2',3-DIMETIL-2,4'-BIPIRIDIN-5-IL)-ACETAMIDO)-5-(PIRAZIN-2-IL)-PIRIDINA; 1'-OXIDO DE 2',3-DIMETIL-5-(2-OXO-2-(5-(PIRAZIN-2-IL)-PIRIDIN-2-IL-AMINO)-ETIL)-2,4'-BIPIRIDINA; ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN MODULADOR DE LA SENALIZACION DE WNT INHIBIENDO LA PROLIFERACION CELULAR SIENDO UTIL EN EL TRATAMIENTO DEL CANCER
PE2011001579A 2009-03-02 2010-03-01 Acetamidas sustituidas por n-(hetero)-arilo y 2-(hetero)-arilo, como moduladores de la senalizacion de wnt PE20120650A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15659909P 2009-03-02 2009-03-02
US24518709P 2009-09-23 2009-09-23

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PE20120650A1 true PE20120650A1 (es) 2012-06-03

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US (4) US8546396B2 (es)
EP (2) EP2403832B1 (es)
JP (2) JP5490153B2 (es)
KR (1) KR101359873B1 (es)
CN (2) CN102369187B (es)
AR (1) AR076067A1 (es)
AU (1) AU2010221493C1 (es)
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CA (1) CA2753552C (es)
CL (1) CL2011002116A1 (es)
CO (1) CO6450669A2 (es)
CR (2) CR20190039A (es)
CU (1) CU24050B1 (es)
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DO (1) DOP2011000273A (es)
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MY (1) MY150583A (es)
NI (1) NI201100165A (es)
NZ (2) NZ595339A (es)
PE (1) PE20120650A1 (es)
PL (1) PL2403832T3 (es)
PT (1) PT2403832E (es)
SG (1) SG173467A1 (es)
SI (1) SI2403832T1 (es)
SM (1) SMT201400032B (es)
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UA (1) UA103918C2 (es)
UY (2) UY32469A (es)
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CA2756535A1 (en) 2009-03-23 2010-09-30 Glenmark Pharmaceuticals, S.A. Furopyrimidinedione derivatives as trpa1 modulators
KR20130016244A (ko) * 2010-03-10 2013-02-14 인게니움 파르마코이티칼스 게엠베하 단백질 키나아제의 억제제
UY33469A (es) * 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
EP2605652B1 (en) 2010-08-18 2017-11-08 Samumed, LLC Diketones and hydroxyketones as catenin signaling pathway activators
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP3693476B1 (en) * 2012-02-28 2023-10-18 Novartis AG Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status
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