PE20110392A1 - Combinacion farmaceutica que comprende heterociclicos nitrogenados antibacterianos con otro antibacteriano - Google Patents
Combinacion farmaceutica que comprende heterociclicos nitrogenados antibacterianos con otro antibacterianoInfo
- Publication number
- PE20110392A1 PE20110392A1 PE2011000865A PE2011000865A PE20110392A1 PE 20110392 A1 PE20110392 A1 PE 20110392A1 PE 2011000865 A PE2011000865 A PE 2011000865A PE 2011000865 A PE2011000865 A PE 2011000865A PE 20110392 A1 PE20110392 A1 PE 20110392A1
- Authority
- PE
- Peru
- Prior art keywords
- pharmaceutical combination
- combination including
- sulfoxi
- diazepin
- pyrazolo
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- SMHWCXRPSKQODY-UHFFFAOYSA-N 4,5-dihydro-1,3-diazepin-6-one Chemical compound O=C1CCN=CN=C1 SMHWCXRPSKQODY-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 AMINomethyl Chemical group 0.000 abstract 1
- WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000305071 Enterobacterales Species 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 abstract 1
- 229960003644 aztreonam Drugs 0.000 abstract 1
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 abstract 1
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 abstract 1
- 229960002260 meropenem Drugs 0.000 abstract 1
- AQIAIZBHFAKICS-UHFFFAOYSA-N methylaminomethyl Chemical class [CH2]NC AQIAIZBHFAKICS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 abstract 1
- 229960000707 tobramycin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE: A) UN ANTIBACTERIANO DE FORMULA (I) DONDE R1 ES (CH2)n-NH2 O (CH2)n-NHR, EN DONDE R ES ALQUILO(C1-C6); n ES 1 O 2; R2 ES H; R3 Y R4 FORMAN JUNTOS UN HETEROCICLO NITROGENADO AROMATICO DE 5 MIEMBROS OPCIONALMENTE SUSTITUIDO CON R', EN DONDE R' ES H O ALQUILO(C1-C6); SIENDO COMPUESTOS PREFERIDOS: TRANS 8-(AMINOMETIL)-4,8-DIHIDRO-1-METIL-5-(SULFOXI)-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPIN-6(5H)-ONA, TRANS 8-(AMINOMETIL)-4,8-DIHIDRO-5-(SULFOXI)-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPIN-6(5H)-ONA, TRANS 8-(METILAMINOMETIL)-4,8-DIHIDRO-5-(SULFOXI)-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPIN-6(5H)-ONA; Y B) OTRO COMPUESTO ANTIBACTERIANO TAL COMO TOBRAMICINA, MEROPENEM, CEFEPIMA, CEFTAZIDIMA, AZTREONAM, POLIMIXINA B, ENTRE OTROS. DICHA COMBINACION TIENE UN EFECTO SINERGICO SIENDO UTIL EN EL TRATAMIENTO DE INFECCIONES CAUSADAS POR PSEUDOMONA AERUGINOSA Y ENTEROBACTERIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0805618A FR2936951B1 (fr) | 2008-10-10 | 2008-10-10 | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110392A1 true PE20110392A1 (es) | 2011-06-11 |
Family
ID=40591054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000865A PE20110392A1 (es) | 2008-10-10 | 2009-09-29 | Combinacion farmaceutica que comprende heterociclicos nitrogenados antibacterianos con otro antibacteriano |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20100092443A1 (es) |
| EP (1) | EP2344500A1 (es) |
| JP (1) | JP2012505196A (es) |
| KR (1) | KR20110067148A (es) |
| CN (1) | CN102216301B (es) |
| AR (1) | AR073771A1 (es) |
| AU (1) | AU2009302153A1 (es) |
| BR (1) | BRPI0919812A8 (es) |
| CA (1) | CA2740035A1 (es) |
| CL (1) | CL2011000783A1 (es) |
| CO (1) | CO6361930A2 (es) |
| EA (1) | EA201170532A1 (es) |
| EC (1) | ECSP11010973A (es) |
| FR (1) | FR2936951B1 (es) |
| IL (1) | IL212180A0 (es) |
| MX (1) | MX2011003812A (es) |
| NZ (1) | NZ592165A (es) |
| PA (1) | PA8845401A1 (es) |
| PE (1) | PE20110392A1 (es) |
| TW (1) | TW201026697A (es) |
| UY (1) | UY32168A (es) |
| WO (1) | WO2010041112A1 (es) |
| ZA (1) | ZA201102498B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20140716A1 (es) | 2010-11-25 | 2014-07-12 | Allecra Therapeutics Gmbh | Compuestos y su usos |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| GB201305277D0 (en) * | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
| EP3055311B1 (en) | 2013-10-11 | 2017-08-09 | Wockhardt Limited | Nitrogen containing compounds and their use |
| AU2015350128B2 (en) * | 2014-11-17 | 2019-05-16 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
| CN114591223B (zh) | 2016-09-16 | 2025-01-24 | 恩塔西斯治疗有限公司 | β-内酰胺酶抑制剂化合物 |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| FI3565551T3 (fi) | 2017-01-09 | 2024-06-18 | Melinta Therapeutics Inc | Menetelmiä bakteeri-infektioiden hoitamiseksi vaborbaktaamin ja meropeneemin yhdistelmällä |
| HUE057592T2 (hu) | 2017-05-08 | 2022-05-28 | Entasis Therapeutics Inc | Vegyületek és eljárások bakteriális fertõzések kezelésére |
| WO2022047603A1 (en) | 2020-09-01 | 2022-03-10 | Ningxia Academy Of Agriculture And Forestry Sciences | Beta-lactamase inhibitors and their preparation |
| WO2022233181A1 (en) | 2021-05-07 | 2022-11-10 | Ningxia Academy Of Agriculture And Forestry Sciences | Sulfonylamidine substituted compounds and their use as beta-lactamase inhibitors |
| GB202213753D0 (en) * | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial combinations |
| CN119998293A (zh) * | 2023-08-08 | 2025-05-13 | 成都四面体药物研究有限公司 | 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途 |
| CN121021489B (zh) * | 2025-10-29 | 2026-01-23 | 潍坊学院 | 卡枯醇叔胺衍生物、制备方法及在制备植物源杀菌剂中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6387928B1 (en) * | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| IL135036A0 (en) * | 1997-09-15 | 2001-05-20 | Procter & Gamble | Antimicrobial quinolones, their compositions and uses |
| CA2406080C (en) * | 2000-04-12 | 2011-11-29 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
| BR0116205A (pt) * | 2000-12-14 | 2003-12-23 | Procter & Gamble | 2-piridonas antimicrobianas, suas composições e usos |
| EP1341781B1 (en) * | 2000-12-14 | 2005-09-14 | The Procter & Gamble Company | Antimicrobial quinolones |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| US7439253B2 (en) * | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| US7232833B2 (en) * | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| US7183267B2 (en) * | 2003-06-10 | 2007-02-27 | The Johns Hopkins University | β-lactamase inhibitors and methods of use thereof |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| CN101129383B (zh) * | 2006-08-25 | 2014-04-02 | 天津和美生物技术有限公司 | 含氨基糖苷类抗生素的抗生素复方 |
| EP1958630A1 (en) * | 2007-02-13 | 2008-08-20 | LEK Pharmaceuticals d.d. | Antibacterial combination of a tricyclic carbapenem and an antibiotic |
-
2008
- 2008-10-10 FR FR0805618A patent/FR2936951B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-05 US US12/535,865 patent/US20100092443A1/en not_active Abandoned
- 2009-09-29 BR BRPI0919812A patent/BRPI0919812A8/pt not_active IP Right Cessation
- 2009-09-29 AU AU2009302153A patent/AU2009302153A1/en not_active Abandoned
- 2009-09-29 JP JP2011530584A patent/JP2012505196A/ja not_active Ceased
- 2009-09-29 MX MX2011003812A patent/MX2011003812A/es active IP Right Grant
- 2009-09-29 NZ NZ592165A patent/NZ592165A/xx not_active IP Right Cessation
- 2009-09-29 CN CN200980146340.2A patent/CN102216301B/zh not_active Expired - Fee Related
- 2009-09-29 PE PE2011000865A patent/PE20110392A1/es not_active Application Discontinuation
- 2009-09-29 CA CA2740035A patent/CA2740035A1/fr not_active Abandoned
- 2009-09-29 WO PCT/IB2009/006992 patent/WO2010041112A1/fr not_active Ceased
- 2009-09-29 EA EA201170532A patent/EA201170532A1/ru unknown
- 2009-09-29 EP EP09786281A patent/EP2344500A1/fr not_active Withdrawn
- 2009-09-29 KR KR1020117010169A patent/KR20110067148A/ko not_active Ceased
- 2009-10-05 AR ARP090103834A patent/AR073771A1/es not_active Application Discontinuation
- 2009-10-07 TW TW098133951A patent/TW201026697A/zh unknown
- 2009-10-08 UY UY0001032168A patent/UY32168A/es not_active Application Discontinuation
- 2009-10-09 PA PA20098845401A patent/PA8845401A1/es unknown
-
2011
- 2011-04-05 ZA ZA2011/02498A patent/ZA201102498B/en unknown
- 2011-04-06 IL IL212180A patent/IL212180A0/en unknown
- 2011-04-08 CO CO11043791A patent/CO6361930A2/es not_active Application Discontinuation
- 2011-04-08 CL CL2011000783A patent/CL2011000783A1/es unknown
- 2011-04-11 EC EC2011010973A patent/ECSP11010973A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ592165A (en) | 2012-12-21 |
| BRPI0919812A8 (pt) | 2016-11-01 |
| US20100092443A1 (en) | 2010-04-15 |
| CO6361930A2 (es) | 2012-01-20 |
| KR20110067148A (ko) | 2011-06-21 |
| WO2010041112A1 (fr) | 2010-04-15 |
| JP2012505196A (ja) | 2012-03-01 |
| AR073771A1 (es) | 2010-12-01 |
| BRPI0919812A2 (pt) | 2015-12-22 |
| FR2936951A1 (fr) | 2010-04-16 |
| ECSP11010973A (es) | 2011-06-30 |
| AU2009302153A1 (en) | 2010-04-15 |
| FR2936951B1 (fr) | 2010-12-03 |
| EA201170532A1 (ru) | 2011-12-30 |
| PA8845401A1 (es) | 2010-05-26 |
| CL2011000783A1 (es) | 2012-07-06 |
| CA2740035A1 (fr) | 2010-04-15 |
| CN102216301B (zh) | 2014-12-10 |
| ZA201102498B (en) | 2013-07-25 |
| IL212180A0 (en) | 2011-06-30 |
| EP2344500A1 (fr) | 2011-07-20 |
| TW201026697A (en) | 2010-07-16 |
| CN102216301A (zh) | 2011-10-12 |
| UY32168A (es) | 2010-04-30 |
| MX2011003812A (es) | 2011-07-29 |
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