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BRPI0919810A8 - Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos - Google Patents

Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Info

Publication number
BRPI0919810A8
BRPI0919810A8 BRPI0919810A BRPI0919810A BRPI0919810A8 BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8 BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8
Authority
BR
Brazil
Prior art keywords
nitrogen
preparation
equal
antibacterial drugs
heterocyclic compounds
Prior art date
Application number
BRPI0919810A
Other languages
English (en)
Inventor
Renaud Emilie
Lampilas Maxime
Rowlands David
Ledoussal Benoit
Gourdel Marie-Edith
Pierres Camille
Kebsi Adel
Original Assignee
Novexel
Astra Zeneca Holding France S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40548019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0919810(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel, Astra Zeneca Holding France S A S filed Critical Novexel
Publication of BRPI0919810A2 publication Critical patent/BRPI0919810A2/pt
Publication of BRPI0919810A8 publication Critical patent/BRPI0919810A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS HETEROCÍCLICOS CONTENDO NITROGÊNIO, SUA PREPARAÇÃO E SEU USO COMO MEDICAMENTOS ANTIBACTERIANOS. A invenção relaciona-se a compostos heterocíclicos contendo nitrogênio de fórmula geral (1) em que: R1 representa um radical (CH2)n-NH2, n sendo igual a 1 ou 2; R2 representa um átomo de hidrogênio; R3 e R4 formam juntos um heterociclo contendo nitrogênio com aromaticidade com 5 ápices, contendo 1, 2 ou 3 átomos de nitrogênio, substituídos nesse átomo de nitrogênio ou em um desses átomos de nitrogênio por um grupo (CH2)m-(C{O))p-Rs, m sendo igual a O, 1, 2 ou 3, p sendo igual a O ou 1 e Rs representando um grupo hidróxi, em que p é igual a 1, ou um amino, (C1-C6)alquila de grupo di-(C1- C6)alquilamino ou um heterociclo contendo nitrogênio com aromaticidade com 5 ou 6 ápices contendo 1 ou 2 átomos de nitrogênio e, se necessário, um átomo de oxigênio ou enxofre; compreende-se que quando o subgrupo (C(O))p-Rs forma um grupo carbóxi, amino, (C1-C6)alquila ou di(C1-C6) lquilamino, m é diferente de O ou 1; na forma livre ou como zwitterions e sais com bases e ácidos minerais ou orgânicos farmaceuticamente aceitáveis, a sua preparação e a seu uso como medicamentos antibacterianos.
BRPI0919810A 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos BRPI0919810A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0805472A FR2936798B1 (fr) 2008-10-03 2008-10-03 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
PCT/IB2009/006433 WO2010038115A1 (fr) 2008-10-03 2009-08-03 Nouveaux composes heterocycliques azotes, leur préparation et leur utilisation comme médicaments antibactériens

Publications (2)

Publication Number Publication Date
BRPI0919810A2 BRPI0919810A2 (pt) 2017-10-31
BRPI0919810A8 true BRPI0919810A8 (pt) 2017-12-12

Family

ID=40548019

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919810A BRPI0919810A8 (pt) 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Country Status (18)

Country Link
US (1) US8067435B2 (pt)
EP (2) EP2344499A1 (pt)
JP (1) JP5555240B2 (pt)
KR (1) KR20110067137A (pt)
CN (1) CN102203094B (pt)
AU (1) AU2009299511A1 (pt)
BR (1) BRPI0919810A8 (pt)
CA (1) CA2739503A1 (pt)
CL (1) CL2011000729A1 (pt)
CO (1) CO6361957A2 (pt)
EA (1) EA021799B1 (pt)
EC (1) ECSP11010946A (pt)
FR (1) FR2936798B1 (pt)
IL (1) IL212059A0 (pt)
MX (1) MX2011003573A (pt)
PE (1) PE20110845A1 (pt)
WO (1) WO2010038115A1 (pt)
ZA (1) ZA201102429B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
PT2872510T (pt) 2011-08-30 2017-03-01 Wockhardt Ltd Derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infeções bacterianas
AU2012310136B2 (en) * 2011-09-13 2016-07-07 Wockhardt Limited Nitrogen containing compounds and their use
JP2015512419A (ja) * 2012-03-30 2015-04-27 キュービスト ファーマシューティカルズ， インコーポレイテッド イソオキザゾールβ−ラクタマーゼ阻害剤
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
EP2857401B8 (en) 2012-05-30 2019-11-20 Meiji Seika Pharma Co., Ltd. NOVEL ß-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME
KR101946107B1 (ko) 2012-08-25 2019-02-08 욱크하르트 리미티드 １,６-디아자비시클로〔３,２,１〕옥탄-７-온 유도체 및 세균 감염의 치료에서의 이의 용도
US10000491B2 (en) 2013-09-24 2018-06-19 Meiji Seika Pharma Co., Ltd. Process for producing diazabicyclooctane derivative and intermediate thereof
NZ719568A (en) 2013-10-08 2018-06-29 Meiji Seika Pharma Co Ltd Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative
EP3055311B1 (en) * 2013-10-11 2017-08-09 Wockhardt Limited Nitrogen containing compounds and their use
AU2015350128B2 (en) 2014-11-17 2019-05-16 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections
AU2015355970B2 (en) 2014-12-05 2020-05-21 Meiji Seika Pharma Co., Ltd. Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
AU2016239209A1 (en) 2015-03-31 2017-10-12 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP3075733A1 (en) * 2015-03-31 2016-10-05 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
AU2016239861A1 (en) * 2015-04-03 2017-10-12 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
HK1254550A1 (zh) 2015-10-02 2019-07-19 乐高化学生物科学股份有限公司 用於抑制β-内酰胺酶的组合物和方法
CN114591223B (zh) 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物
HUE057592T2 (hu) 2017-05-08 2022-05-28 Entasis Therapeutics Inc Vegyületek és eljárások bakteriális fertõzések kezelésére
EP3604315A1 (en) * 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CN119998293A (zh) * 2023-08-08 2025-05-13 成都四面体药物研究有限公司 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL135036A0 (en) * 1997-09-15 2001-05-20 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
BR0116205A (pt) * 2000-12-14 2003-12-23 Procter & Gamble 2-piridonas antimicrobianas, suas composições e usos
EP1341781B1 (en) * 2000-12-14 2005-09-14 The Procter & Gamble Company Antimicrobial quinolones
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7232833B2 (en) * 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Also Published As

Publication number Publication date
EP2845855A1 (fr) 2015-03-11
IL212059A0 (en) 2011-06-30
PE20110845A1 (es) 2011-11-17
WO2010038115A1 (fr) 2010-04-08
CO6361957A2 (es) 2012-01-20
KR20110067137A (ko) 2011-06-21
CN102203094A (zh) 2011-09-28
ECSP11010946A (es) 2011-05-31
BRPI0919810A2 (pt) 2017-10-31
CL2011000729A1 (es) 2012-07-06
FR2936798A1 (fr) 2010-04-09
CA2739503A1 (fr) 2010-04-08
CN102203094B (zh) 2014-04-02
JP2012504593A (ja) 2012-02-23
ZA201102429B (en) 2012-05-30
US8067435B2 (en) 2011-11-29
FR2936798B1 (fr) 2012-09-28
AU2009299511A1 (en) 2010-04-08
MX2011003573A (es) 2011-08-12
EA201170522A1 (ru) 2011-12-30
JP5555240B2 (ja) 2014-07-23
US20100087648A1 (en) 2010-04-08
EP2344499A1 (fr) 2011-07-20
EA021799B1 (ru) 2015-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: ASTRA ZENECA HOLDING FRANCE S.A.S. (FR)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]