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PE20110307A1 - Derivados de aminodihidrotiazina fusionada con actividad sobre la proteina beta-amiloide - Google Patents

Derivados de aminodihidrotiazina fusionada con actividad sobre la proteina beta-amiloide

Info

Publication number
PE20110307A1
PE20110307A1 PE2011000781A PE2011000781A PE20110307A1 PE 20110307 A1 PE20110307 A1 PE 20110307A1 PE 2011000781 A PE2011000781 A PE 2011000781A PE 2011000781 A PE2011000781 A PE 2011000781A PE 20110307 A1 PE20110307 A1 PE 20110307A1
Authority
PE
Peru
Prior art keywords
beta
group
azanaftalen
oxa
carboxamide
Prior art date
Application number
PE2011000781A
Other languages
English (en)
Inventor
Takafumi Motoki
Kunitoshi Takeda
Yoichi Kita
Mamoru Takaishi
Yuichi Suzuki
Tasuku Ishida
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20110307A1 publication Critical patent/PE20110307A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE AMINODIHIDROTIAZINA FUSIONADA DE FORMULA (I), DONDE A ES UN GRUPO ARILO C6-C14, UN GRUPO HETEROARILO DE 5 A 6 MIEMBROS CON HETEROATOMOS TALES COMO N, S Y O, UN GRUPO HETEROCICLICO BENZO-FUSIONADO DE 9 A 10 MIEMBROS, ENTRE OTROS; L ES UN ENLACE, UN ATOMO DE OXIGENO, ENTRE OTROS; B ES CICLOALQUILO C3-C8, ARILO C6-C14, UN GRUPO HETEROCICLICO DE 5 A 10 MIEMBROS CON HETEROATOMOS TALES COMO N, S Y O, ENTRE OTROS; X ES UN ENLACE, ALQUILENO C1-C3, ENTRE OTROS; Y ES ALQUILENO C1-C3, ALQUENILENO C2-C3, ENTRE OTROS; Z ES O, S, SULFOXIDO, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C6, ALQUILCARBONILO C1-C6, ENTRE OTROS; R3, R4, R5 Y R6 SON H, OH, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[3-((4aR*,8aS*)-2-AMINO-4,4a,5,6-TETRAHIDRO-7-OXA-3-TIA-1-AZANAFTALEN-8a-IL)-4-FLUOROFENIL]-5-CIANOPIRIDINA-2-CARBOXAMIDA, N-[3-((8S*,8aR*)-2-AMINO-4,4a,5,6-TETRAHIDRO-7-OXA-3-TIA-1-AZANAFTALEN-8a-IL)-4-FLUOROFENIL]-5-FLUOROMETOXIPIRAZINA-2-CARBOXAMIDA, N-[3-((4aR*,8aS*)-2-AMINO-4,4a,5,6-TETRAHIDRO-7-OXA-3-TIA-1-AZANAFTALEN-8a-IL)-4-FLUOROFENIL]-5-DIFLUOROMETOXIPIRAZINA-2-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA PRODUCCION DE PROTEINA BETA-AMILOIDE O LA ENZIMA 1 DE ESCISION DE LA PROTEINA PRECURSORA BETA-AMILOIDE, SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS TALES COMO ALZHEIMER, SINDROME DE DOWN, ENTRE OTRAS
PE2011000781A 2008-09-30 2009-09-28 Derivados de aminodihidrotiazina fusionada con actividad sobre la proteina beta-amiloide PE20110307A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10135908P 2008-09-30 2008-09-30
JP2008252062 2008-09-30
US17017909P 2009-04-17 2009-04-17
JP2009100457 2009-04-17
US22636509P 2009-07-17 2009-07-17
JP2009168490 2009-07-17

Publications (1)

Publication Number Publication Date
PE20110307A1 true PE20110307A1 (es) 2011-05-21

Family

ID=42073450

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000781A PE20110307A1 (es) 2008-09-30 2009-09-28 Derivados de aminodihidrotiazina fusionada con actividad sobre la proteina beta-amiloide

Country Status (16)

Country Link
US (2) US20110207723A1 (es)
EP (1) EP2332943B1 (es)
JP (1) JP5666304B2 (es)
KR (1) KR20110076965A (es)
CN (1) CN102171221B (es)
AR (1) AR073406A1 (es)
AU (1) AU2009300836B2 (es)
CA (1) CA2738150A1 (es)
ES (1) ES2539859T3 (es)
IL (1) IL211933A (es)
MX (1) MX2011003189A (es)
NZ (1) NZ591878A (es)
PE (1) PE20110307A1 (es)
TW (1) TW201016708A (es)
WO (1) WO2010038686A1 (es)
ZA (1) ZA201102172B (es)

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Also Published As

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CN102171221A (zh) 2011-08-31
IL211933A0 (en) 2011-06-30
US20100093999A1 (en) 2010-04-15
EP2332943A4 (en) 2012-03-14
NZ591878A (en) 2012-06-29
IL211933A (en) 2015-03-31
JPWO2010038686A1 (ja) 2012-03-01
ZA201102172B (en) 2012-10-31
AR073406A1 (es) 2010-11-03
AU2009300836A1 (en) 2010-04-08
US8198269B2 (en) 2012-06-12
US20110207723A1 (en) 2011-08-25
ES2539859T3 (es) 2015-07-06
JP5666304B2 (ja) 2015-02-12
KR20110076965A (ko) 2011-07-06
AU2009300836B2 (en) 2014-02-27
WO2010038686A1 (ja) 2010-04-08
EP2332943A1 (en) 2011-06-15
CA2738150A1 (en) 2010-04-08
MX2011003189A (es) 2011-04-27
EP2332943B1 (en) 2015-04-22
TW201016708A (en) 2010-05-01
CN102171221B (zh) 2013-11-06

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