PE20110163A1 - Proceso para la preparacion de derivados de pirimidina sustituidos - Google Patents
Proceso para la preparacion de derivados de pirimidina sustituidosInfo
- Publication number
- PE20110163A1 PE20110163A1 PE2010001216A PE2010001216A PE20110163A1 PE 20110163 A1 PE20110163 A1 PE 20110163A1 PE 2010001216 A PE2010001216 A PE 2010001216A PE 2010001216 A PE2010001216 A PE 2010001216A PE 20110163 A1 PE20110163 A1 PE 20110163A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- alkyl
- preparation
- produce
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- -1 ISOPROPYL Chemical class 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- 102000004187 Histamine H4 receptors Human genes 0.000 abstract 1
- 108090000796 Histamine H4 receptors Proteins 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical class [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN PROCESO DE PREPARACION DE DERIVADOS DE PIRIMIDINA DE FORMULA (I) QUE COMPRENDE: a) HACER REACCIONAR UN COMPUESTO DE FORMULA (V) CON UN COMPUESTO DE FORMULA (VI), EN PRESENCIA DE UN SISTEMA DE AGENTES DE ACOPLAMIENTO TALES COMO DIISOPROPILAZODICARBOXILATO Y TRIFENILFOSFINA, O EN UN PRIMER SOLVENTE ORGANICO TAL COMO 2-METIL-TETRAHIDROFURANO, PARA PRODUCIR EL COMPUESTO DE FORMULA (VII), b) DESPROTEGER EL COMPUESTO (VII) PARA PRODUCIR EL COMPUESTO DE FORMULA (VIII), c) HACER REACCIONAR EL COMPUESTO (VIII) CON UN COMPUESTO DE FORMULA (IX), EN UN SEGUNDO SOLVENTE ORGANICO TAL COMO ETANOL, PARA PRODUCIR EL COMPUESTO DE FORMULA (I); EN DONDE L1 ES CN; Rc ES H, METILO, ETILO, PROPILO, ISOPROPILO, CF3, CICLOPROPILO Y CICLOBUTILO; R6 ES H; R8 ES H O ALQUILO C1-C4; Z ES N O CH; n ES 1 O 2; R9, R10 Y R11 SON H O ALQUILO C1-C4; PG1 Y PG2 SON UN GRUPO DE PROTECCION DE NITROGENO TAL COMO BENCILOXICARBONIL; LG1 ES UN GRUPO DE SALIDA TAL COMO TOSILATO, OH, ENTRE OTROS; X ES N(R20)2 U OR21; R20 ES ALQUILO C1-C4; R21 ES ALQUILO C1-C4 O BENCILO. DICHOS COMPUESTOS DE FORMULA (I) SON UTILES COMO INTERMEDIARIOS EN LA SINTESIS DE MODULADORES DEL RECEPTOR H4 DE HISTAMINA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7675208P | 2008-06-30 | 2008-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110163A1 true PE20110163A1 (es) | 2011-03-28 |
Family
ID=41464882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001216A PE20110163A1 (es) | 2008-06-30 | 2009-06-29 | Proceso para la preparacion de derivados de pirimidina sustituidos |
Country Status (36)
| Country | Link |
|---|---|
| US (6) | US8309720B2 (es) |
| EP (5) | EP2310012B1 (es) |
| JP (1) | JP5416768B2 (es) |
| KR (1) | KR101675354B1 (es) |
| CN (1) | CN102137672B (es) |
| AR (1) | AR072396A1 (es) |
| AU (1) | AU2009267156B2 (es) |
| BR (1) | BRPI0913644A2 (es) |
| CA (1) | CA2729733C (es) |
| CO (1) | CO6341560A2 (es) |
| CY (1) | CY1116134T1 (es) |
| DK (1) | DK2310012T3 (es) |
| EA (1) | EA019361B1 (es) |
| EC (1) | ECSP11010745A (es) |
| ES (1) | ES2538135T3 (es) |
| HK (3) | HK1201441A1 (es) |
| HR (1) | HRP20150576T1 (es) |
| HU (1) | HUE024949T2 (es) |
| IL (4) | IL210214A (es) |
| JO (1) | JO3043B1 (es) |
| ME (1) | ME02154B (es) |
| MX (1) | MX2011000080A (es) |
| MY (1) | MY150601A (es) |
| NI (1) | NI201000232A (es) |
| NZ (1) | NZ590170A (es) |
| PE (1) | PE20110163A1 (es) |
| PL (1) | PL2310012T3 (es) |
| PT (1) | PT2310012E (es) |
| RS (1) | RS53985B1 (es) |
| SI (1) | SI2310012T1 (es) |
| SV (1) | SV2011003788A (es) |
| TW (3) | TWI481603B (es) |
| UA (1) | UA106724C2 (es) |
| UY (1) | UY31949A (es) |
| WO (1) | WO2010002774A1 (es) |
| ZA (1) | ZA201100759B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2007752T1 (sl) | 2006-03-31 | 2010-12-31 | Janssen Pharmaceutica Nv | Benzoimidazol-2-il pirimidini in pirazini kot modulatorji histamin H4 receptorja |
| UA106724C2 (uk) | 2008-06-30 | 2014-10-10 | Янссен Фармацевтика Нв | Спосіб отримання заміщених піримідинових похідних |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| JP5574294B2 (ja) * | 2010-11-04 | 2014-08-20 | 独立行政法人科学技術振興機構 | 光磁気記録媒体及び光磁気記録方法 |
| SG11201507117XA (en) | 2013-03-06 | 2015-10-29 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor |
| JP6484220B2 (ja) * | 2014-03-28 | 2019-03-13 | 株式会社カネカ | トリ−カルボベンゾキシ−アルギニンの製造方法 |
| US10723723B2 (en) | 2016-11-03 | 2020-07-28 | Bristol-Myers Squibb Company | Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3005852A (en) | 1959-12-22 | 1961-10-24 | Gen Aniline & Film Corp | Production of sulfoxides and sulfones |
| US3931195A (en) * | 1971-03-03 | 1976-01-06 | Mead Johnson & Company | Substituted piperidines |
| US4191828A (en) * | 1976-04-14 | 1980-03-04 | Richardson-Merrell Inc. | Process for preparing 2-(2,2-dicyclohexylethyl)piperidine |
| US4190601A (en) | 1978-05-31 | 1980-02-26 | Union Carbide Corporation | Production of tertiary amines by reductive alkylation |
| JPS5942396A (ja) * | 1982-09-02 | 1984-03-08 | Ishihara Sangyo Kaisha Ltd | リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤 |
| JPS6130576A (ja) | 1984-07-24 | 1986-02-12 | Ube Ind Ltd | ２−アミノ−５−シアノピリミジンの製法 |
| WO1994008577A1 (en) * | 1992-10-14 | 1994-04-28 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| GB9422391D0 (en) | 1994-11-05 | 1995-01-04 | Solvay Interox Ltd | Oxidation of organosulphur compounds |
| KR20010041015A (ko) | 1998-02-17 | 2001-05-15 | 윌리엄 제이. 리플린 | 항바이러스성 피리미딘 유도체 |
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| PL354675A1 (en) * | 1999-09-30 | 2004-02-09 | Neurogen Corporation | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines |
| HUP0301038A3 (en) | 2000-07-21 | 2004-06-28 | Syngenta Participations Ag | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| AU2002258400A1 (en) | 2001-02-16 | 2002-08-28 | Tularik Inc. | Methods of using pyrimidine-based antiviral agents |
| EP1372642A1 (en) * | 2001-03-30 | 2004-01-02 | SmithKline Beecham Corporation | Use of pyrazolopyridines as therapeutic compounds |
| EP1463730B1 (en) * | 2001-12-17 | 2006-04-19 | SmithKline Beecham Corporation | Pyrazolopyridazine derivatives |
| TWI270542B (en) | 2002-02-07 | 2007-01-11 | Sumitomo Chemical Co | Method for preparing sulfone or sulfoxide compound |
| DE60329030D1 (de) * | 2002-12-04 | 2009-10-08 | Ore Pharmaceuticals Inc | Melanocortin-rezeptormodulatoren |
| KR100767272B1 (ko) * | 2003-05-05 | 2007-10-17 | 에프. 호프만-라 로슈 아게 | Ｃｒｆ 활성을 갖는 융합 피리미딘 유도체 |
| EP2371954A1 (en) | 2004-10-27 | 2011-10-05 | Schering Corporation | Compositions and methods for short interfering nucleic acid inhibition of NAv1.8 |
| CA2612227C (en) | 2005-06-14 | 2014-04-22 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| AU2006266529B2 (en) * | 2005-07-06 | 2010-12-16 | Cytiva Bioprocess R&D Ab | Method of preparing a separation matrix |
| TW200800201A (en) * | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| CN101032483B (zh) * | 2006-03-09 | 2011-05-04 | 陈德桂 | 调节雄激素受体活性的乙内酰脲衍生物及其应用 |
| US7589087B2 (en) * | 2006-03-31 | 2009-09-15 | Janssen Pharmaceutica, N.V. | Benzoimidazol-2-yl pyridines as modulators of the histamine H4receptor |
| SI2007752T1 (sl) * | 2006-03-31 | 2010-12-31 | Janssen Pharmaceutica Nv | Benzoimidazol-2-il pirimidini in pirazini kot modulatorji histamin H4 receptorja |
| CN102137857A (zh) * | 2008-06-30 | 2011-07-27 | 詹森药业有限公司 | 用于制备苯并咪唑-2-基嘧啶衍生物的方法 |
| UA106724C2 (uk) | 2008-06-30 | 2014-10-10 | Янссен Фармацевтика Нв | Спосіб отримання заміщених піримідинових похідних |
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2009
- 2009-06-29 UA UAA201100983A patent/UA106724C2/uk unknown
- 2009-06-29 US US12/459,229 patent/US8309720B2/en not_active Expired - Fee Related
- 2009-06-29 JP JP2011516757A patent/JP5416768B2/ja not_active Expired - Fee Related
- 2009-06-29 CA CA2729733A patent/CA2729733C/en not_active Expired - Fee Related
- 2009-06-29 TW TW103104509A patent/TWI481603B/zh not_active IP Right Cessation
- 2009-06-29 JO JOP/2009/0240A patent/JO3043B1/ar active
- 2009-06-29 SI SI200931188T patent/SI2310012T1/sl unknown
- 2009-06-29 ME MEP-2015-79A patent/ME02154B/me unknown
- 2009-06-29 CN CN200980134933.7A patent/CN102137672B/zh not_active Expired - Fee Related
- 2009-06-29 TW TW098121755A patent/TWI498326B/zh not_active IP Right Cessation
- 2009-06-29 EP EP20090774225 patent/EP2310012B1/en active Active
- 2009-06-29 RS RS20150287A patent/RS53985B1/sr unknown
- 2009-06-29 PL PL09774225T patent/PL2310012T3/pl unknown
- 2009-06-29 EP EP20140161564 patent/EP2769721A3/en not_active Withdrawn
- 2009-06-29 BR BRPI0913644A patent/BRPI0913644A2/pt not_active Application Discontinuation
- 2009-06-29 ES ES09774225.8T patent/ES2538135T3/es active Active
- 2009-06-29 WO PCT/US2009/049027 patent/WO2010002774A1/en not_active Ceased
- 2009-06-29 MX MX2011000080A patent/MX2011000080A/es active IP Right Grant
- 2009-06-29 AR ARP090102405 patent/AR072396A1/es not_active Application Discontinuation
- 2009-06-29 EA EA201170113A patent/EA019361B1/ru not_active IP Right Cessation
- 2009-06-29 HU HUE09774225A patent/HUE024949T2/en unknown
- 2009-06-29 KR KR1020117001991A patent/KR101675354B1/ko not_active Expired - Fee Related
- 2009-06-29 HR HRP20150576TT patent/HRP20150576T1/hr unknown
- 2009-06-29 DK DK09774225T patent/DK2310012T3/da active
- 2009-06-29 NZ NZ590170A patent/NZ590170A/en not_active IP Right Cessation
- 2009-06-29 EP EP15157463.9A patent/EP2924025A1/en not_active Withdrawn
- 2009-06-29 MY MYPI2010006258A patent/MY150601A/en unknown
- 2009-06-29 AU AU2009267156A patent/AU2009267156B2/en not_active Ceased
- 2009-06-29 PT PT97742258T patent/PT2310012E/pt unknown
- 2009-06-29 PE PE2010001216A patent/PE20110163A1/es not_active Application Discontinuation
- 2009-06-29 EP EP15157445.6A patent/EP2924035A1/en not_active Withdrawn
- 2009-06-29 EP EP15157453.0A patent/EP2924023A1/en not_active Withdrawn
- 2009-06-29 TW TW103118001A patent/TW201433568A/zh unknown
- 2009-06-30 UY UY31949A patent/UY31949A/es unknown
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2010
- 2010-12-23 IL IL210214A patent/IL210214A/en active IP Right Grant
- 2010-12-23 NI NI201000232A patent/NI201000232A/es unknown
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2011
- 2011-01-03 SV SV2011003788A patent/SV2011003788A/es unknown
- 2011-01-04 CO CO11000461A patent/CO6341560A2/es not_active Application Discontinuation
- 2011-01-05 EC ECSP11010745 patent/ECSP11010745A/es unknown
- 2011-01-28 ZA ZA2011/00759A patent/ZA201100759B/en unknown
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2012
- 2012-10-29 US US13/663,233 patent/US9079882B2/en not_active Expired - Fee Related
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2013
- 2013-03-15 US US13/844,227 patent/US9079883B2/en not_active Expired - Fee Related
- 2013-11-11 US US14/076,955 patent/US9079884B2/en not_active Expired - Fee Related
- 2013-11-12 US US14/078,153 patent/US9006432B2/en not_active Expired - Fee Related
- 2013-11-13 US US14/079,358 patent/US9359327B2/en not_active Expired - Fee Related
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2014
- 2014-11-09 IL IL235572A patent/IL235572A/en active IP Right Grant
- 2014-11-09 IL IL235571A patent/IL235571A/en active IP Right Grant
- 2014-11-09 IL IL235570A patent/IL235570A/en active IP Right Grant
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2015
- 2015-02-26 HK HK15101911.7A patent/HK1201441A1/en unknown
- 2015-03-23 CY CY20151100293T patent/CY1116134T1/el unknown
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2016
- 2016-03-03 HK HK16102449.5A patent/HK1214590A1/en unknown
- 2016-03-23 HK HK16103405.5A patent/HK1215434A1/en unknown
Also Published As
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