PE20110417A1 - Proceso para la preparacion de derivados de l-alanina protegidos - Google Patents
Proceso para la preparacion de derivados de l-alanina protegidosInfo
- Publication number
- PE20110417A1 PE20110417A1 PE2011000939A PE2011000939A PE20110417A1 PE 20110417 A1 PE20110417 A1 PE 20110417A1 PE 2011000939 A PE2011000939 A PE 2011000939A PE 2011000939 A PE2011000939 A PE 2011000939A PE 20110417 A1 PE20110417 A1 PE 20110417A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- organic solvent
- alkyl
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
Abstract
REFERIDA A UN PROCESO DE PREPARACION DE UN COMPUESTO DE FORMULA (I), DONDE PG1 ES UN GRUPO PROTECTOR DE NITROGENO TAL COMO TERT-BUTOXICARBONILO (Boc); R0 ES H, ALQUILO C1-C4 Y BENCILO; R6 ES H O ALQUILO C1-C6; R4 ES ARILO O HETEROARILO. DICHO PROCESO CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (X), EN PRESENCIA DE UNA FUENTE DE YODO, EN UN PRIMER SOLVENTE ORGANICO O UNA MEZCLA DE SOLVENTES ORGANICOS, PARA OBTENER UN COMPUESTO DE FORMULA (XI) QUE SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA R4-LG1, EN PRESENCIA DE UN CATALIZADOR DE PALADIO Y UN SISTEMA DE LIGANDOS DE FOSFINA QUE ES UNA COMBINACION DE Pd2(dba)3 Y P(o-tol)3, EN UN SEGUNDO DISOLVENTE ORGANICO O UNA MEZCLA DE DISOLVENTES ORGANICOS, PARA OBTENER EL COMPUESTO DE FORMULA (I); DONDE PG1 ES UN GRUPO DE PROTECCION DE NITROGENO CON ZINC, EL PRIMER SOLVENTE ORGANICO NO ES REACTIVO A LA FUENTE DE YODO Y ES DIMETILACETAMIDA, LG1 ES UN GRUPO SALIENTE TAL COMO BROMO. LOS COMPUESTOS DERIVADOS DE L-ALANINA OBTENIDOS MEDIANTE ESTE PROCEDIMIENTO SON UTILES COMO INTERNEDIARIOS DE LA SINTESIS DE COMPUESTOS MODULADORES OPIOIDES MU/DELTA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10864908P | 2008-10-27 | 2008-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110417A1 true PE20110417A1 (es) | 2011-06-22 |
Family
ID=41796530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000876A PE20141698A1 (es) | 2008-10-27 | 2009-10-27 | Proceso para la preparacion de derivados de l-alanina protegidos |
| PE2011000939A PE20110417A1 (es) | 2008-10-27 | 2009-10-27 | Proceso para la preparacion de derivados de l-alanina protegidos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000876A PE20141698A1 (es) | 2008-10-27 | 2009-10-27 | Proceso para la preparacion de derivados de l-alanina protegidos |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8710256B2 (es) |
| EP (1) | EP2362868B1 (es) |
| JP (2) | JP5592893B2 (es) |
| KR (1) | KR101690195B1 (es) |
| CN (2) | CN102264691B (es) |
| AR (1) | AR075291A1 (es) |
| AU (1) | AU2009320156B2 (es) |
| BR (1) | BRPI0920834B1 (es) |
| CA (1) | CA2741790C (es) |
| CL (1) | CL2011000936A1 (es) |
| CO (1) | CO6361989A2 (es) |
| CR (1) | CR20110286A (es) |
| EA (1) | EA018913B1 (es) |
| EC (1) | ECSP11011008A (es) |
| ES (1) | ES2657676T3 (es) |
| HN (1) | HN2011001186A (es) |
| HU (1) | HUE038302T2 (es) |
| IL (1) | IL212464A (es) |
| MX (1) | MX2011004393A (es) |
| NI (1) | NI201100078A (es) |
| NZ (1) | NZ592415A (es) |
| PE (2) | PE20141698A1 (es) |
| TW (1) | TWI468375B (es) |
| UA (1) | UA110600C2 (es) |
| WO (1) | WO2010062590A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之ｌ－丙胺酸衍生物之方法 |
| TWI579296B (zh) | 2011-12-28 | 2017-04-21 | Chugai Pharmaceutical Co Ltd | Cyclization of Peptide Compounds |
| SG11201606351VA (en) | 2014-02-03 | 2016-09-29 | Quadriga Biosciences Inc | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| EP3102194A1 (en) | 2014-02-03 | 2016-12-14 | Quadriga Biosciences, Inc. | Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents |
| DK3269809T3 (da) | 2015-03-13 | 2022-09-12 | Chugai Pharmaceutical Co Ltd | MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF |
| US9783487B2 (en) | 2015-08-03 | 2017-10-10 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
| WO2017043626A1 (ja) * | 2015-09-11 | 2017-03-16 | 株式会社カネカ | 光学活性４－カルバモイル－２，６－ジメチルフェニルアラニン誘導体の製造法 |
| CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
| CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
| WO2018055528A2 (en) * | 2016-09-20 | 2018-03-29 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
| CN106636246B (zh) * | 2016-12-28 | 2020-03-24 | 尚科生物医药（上海）有限公司 | 生物法制备(s)-1-(5-苯基-1h-咪唑-2-基)乙胺 |
| CN106636241B (zh) * | 2016-12-28 | 2020-04-03 | 尚科生物医药（上海）有限公司 | 一种酶法制备艾沙度林中间体的方法 |
| CN106866463B (zh) * | 2017-01-24 | 2018-08-28 | 富乐马鸿凯（大连）医药有限公司 | 艾沙度林中间体的制备方法 |
| US12391971B2 (en) | 2017-01-31 | 2025-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptides in cell-free translation system |
| US11542299B2 (en) | 2017-06-09 | 2023-01-03 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptide containing N-substituted amino acid |
| US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
| CN110092735B (zh) * | 2018-01-31 | 2021-05-11 | 尚科生物医药（上海）有限公司 | 一种l-丙氨酸衍生物的制备方法 |
| WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
| JP7279073B2 (ja) | 2018-11-07 | 2023-05-22 | 中外製薬株式会社 | Ｏ－置換セリン誘導体の製造方法 |
| CN119143631A (zh) | 2018-11-30 | 2024-12-17 | 中外制药株式会社 | 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法 |
| JP7472101B2 (ja) * | 2019-03-15 | 2024-04-22 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
| TWI850887B (zh) | 2019-11-07 | 2024-08-01 | 日商中外製藥股份有限公司 | 具有Kras抑制作用的環狀胜肽化合物 |
| CN111620876B (zh) * | 2020-05-07 | 2021-09-28 | 普济生物科技（台州）有限公司 | 瑞德西韦关键中间体的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2780372B2 (ja) | 1989-08-29 | 1998-07-30 | 株式会社日立製作所 | デイスク制御装置のキヤツシユ組込制御方法 |
| JP2881473B2 (ja) * | 1990-03-30 | 1999-04-12 | 日産化学工業株式会社 | α―置換シクロペンテノン誘導体及びその製造法並びに該誘導体を得るための有機亜鉛試剤 |
| US5554753A (en) * | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
| SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
| JP4228587B2 (ja) * | 2002-05-22 | 2009-02-25 | 昭和電工株式会社 | アミノメチル基含有ベンズアミド化合物の製造方法 |
| AU2003298311A1 (en) | 2002-12-04 | 2004-06-23 | Ciba Specialty Chemicals Holding Inc. | Process for the synthesis of cycloorganylphosphanes and di(alkali metal/alkaline earth metal) oligophosphanediides |
| CN102786476B (zh) * | 2004-03-15 | 2017-01-18 | 詹森药业有限公司 | 作为阿片受体调节剂的化合物 |
| NZ590570A (en) * | 2005-03-14 | 2012-06-29 | Janssen Pharmaceutica Nv | Process for the preparation of opioid modulators |
| TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之ｌ－丙胺酸衍生物之方法 |
-
2009
- 2009-10-26 TW TW98136147A patent/TWI468375B/zh not_active IP Right Cessation
- 2009-10-27 US US12/606,730 patent/US8710256B2/en active Active
- 2009-10-27 MX MX2011004393A patent/MX2011004393A/es active IP Right Grant
- 2009-10-27 HU HUE09752026A patent/HUE038302T2/hu unknown
- 2009-10-27 PE PE2014000876A patent/PE20141698A1/es not_active Application Discontinuation
- 2009-10-27 WO PCT/US2009/062191 patent/WO2010062590A2/en not_active Ceased
- 2009-10-27 CN CN200980153642.2A patent/CN102264691B/zh not_active Expired - Fee Related
- 2009-10-27 UA UAA201106621A patent/UA110600C2/uk unknown
- 2009-10-27 AU AU2009320156A patent/AU2009320156B2/en not_active Ceased
- 2009-10-27 JP JP2011534675A patent/JP5592893B2/ja not_active Expired - Fee Related
- 2009-10-27 ES ES09752026.6T patent/ES2657676T3/es active Active
- 2009-10-27 KR KR1020117011699A patent/KR101690195B1/ko not_active Expired - Fee Related
- 2009-10-27 PE PE2011000939A patent/PE20110417A1/es active IP Right Grant
- 2009-10-27 AR ARP090104133A patent/AR075291A1/es active IP Right Grant
- 2009-10-27 CA CA2741790A patent/CA2741790C/en active Active
- 2009-10-27 CN CN201710219076.7A patent/CN107382781A/zh active Pending
- 2009-10-27 NZ NZ592415A patent/NZ592415A/xx not_active IP Right Cessation
- 2009-10-27 EA EA201170618A patent/EA018913B1/ru unknown
- 2009-10-27 EP EP09752026.6A patent/EP2362868B1/en active Active
- 2009-10-27 BR BRPI0920834-8A patent/BRPI0920834B1/pt not_active IP Right Cessation
-
2011
- 2011-04-26 CL CL2011000936A patent/CL2011000936A1/es unknown
- 2011-04-26 IL IL212464A patent/IL212464A/en active IP Right Grant
- 2011-04-27 CO CO11051582A patent/CO6361989A2/es active IP Right Grant
- 2011-04-27 NI NI201100078A patent/NI201100078A/es unknown
- 2011-04-27 EC EC2011011008A patent/ECSP11011008A/es unknown
- 2011-04-27 HN HN2011001186A patent/HN2011001186A/es unknown
- 2011-05-27 CR CR20110286A patent/CR20110286A/es unknown
-
2014
- 2014-01-23 US US14/162,150 patent/US8853445B2/en active Active
- 2014-07-31 JP JP2014155710A patent/JP2015013862A/ja active Pending
- 2014-09-05 US US14/478,253 patent/US9187408B2/en active Active
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| FG | Grant, registration |