[go: up one dir, main page]

PE20110162A1 - Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas - Google Patents

Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Info

Publication number
PE20110162A1
PE20110162A1 PE2010001131A PE2010001131A PE20110162A1 PE 20110162 A1 PE20110162 A1 PE 20110162A1 PE 2010001131 A PE2010001131 A PE 2010001131A PE 2010001131 A PE2010001131 A PE 2010001131A PE 20110162 A1 PE20110162 A1 PE 20110162A1
Authority
PE
Peru
Prior art keywords
ophthalmic compositions
new alternative
povidone iodide
pvp
alternative preservative
Prior art date
Application number
PE2010001131A
Other languages
English (en)
Inventor
Joseph A Capriotti
Bo Liang
C Michael Samson
Jason Stein
Michael Weiser
Original Assignee
Foresight Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41417019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110162(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Foresight Biotherapeutics Inc filed Critical Foresight Biotherapeutics Inc
Publication of PE20110162A1 publication Critical patent/PE20110162A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/10—Halogens or compounds thereof
    • A61L12/105—Iodine, iodides or iodophores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA DE USO OFTALMICO QUE COMPRENDE: A) YODURO DE POVIDONA (PVP-I) ENTRE 0.01% A 10%; B) UN COMPUESTO ANTIINFLAMATORIO SELECCIONADO ENTRE DICLOFENACO DE SODIO, NEPAFENACO DEXAMETASONA, ENTRE OTROS; UN COMPUESTO ANTIBACTERIAL; ANTIALERGICO O ANTIGLAUCOMA; C) UN LUBRICANTE A BASE DE LAGRIMAS ARTIFICIALES. ADEMAS PUEDE CONTENER UN CONSERVANTE ANTIMICROBIANO SELECCIONADO ENTRE CLORURO DE BENZALCONIO, TIMEROSAL, CLOROBUTANOL, ENTRE OTROS; Y UN AGENTE QUE AUMENTA LA VISCOSIDAD SELECCIONADO ENTRE POLIVINIL ALCOHOL, POLIVINILPIRROLIDONA, METIL CELULOSA, ENTRE OTROS. DICHA PREPARACION AL CONTENER PVP-I PRESENTA MENOR POTENCIAL DE TOXICIDAD QUE OTRAS PREPARACIONES SIMILARES
PE2010001131A 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas PE20110162A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12922208P 2008-06-12 2008-06-12
US20185408P 2008-12-15 2008-12-15

Publications (1)

Publication Number Publication Date
PE20110162A1 true PE20110162A1 (es) 2011-04-06

Family

ID=41417019

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013002829A PE20141185A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas
PE2010001131A PE20110162A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013002829A PE20141185A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Country Status (20)

Country Link
US (2) US20120027716A1 (es)
EP (2) EP3777536A1 (es)
JP (4) JP2011522891A (es)
KR (3) KR20160045153A (es)
CN (3) CN102118973A (es)
AU (1) AU2009258145A1 (es)
BR (1) BRPI0913417B1 (es)
CA (2) CA2727605C (es)
CL (1) CL2010001406A1 (es)
CO (1) CO6341526A2 (es)
DK (1) DK2291081T3 (es)
EC (1) ECSP11010755A (es)
ES (1) ES2810863T3 (es)
HK (1) HK1202074A1 (es)
MX (3) MX372536B (es)
NZ (3) NZ603346A (es)
PE (2) PE20141185A1 (es)
PL (1) PL2291081T3 (es)
PT (1) PT2291081T (es)
WO (1) WO2009151619A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263345A1 (en) * 2008-01-28 2009-10-22 Foresight Biotherapeutics, Inc. Otic compositions for the treatment of infections of the internal and external ear in mammals
WO2011084473A1 (en) * 2009-12-15 2011-07-14 Foresight Biotherapeutics, Inc. Non-irritating ophthalmic povidone-iodine compositions
AU2015252097A1 (en) * 2009-12-15 2015-11-19 Foresight Biotherapeutics, Inc. Non-irritating ophthalmic povidone-iodine compositions
US20120135947A1 (en) * 2010-11-29 2012-05-31 Mitsubishi Tanabe Pharma Corporation Oil-in-water emulsion composition containing difluprednate and tobramycin
KR102075173B1 (ko) * 2011-01-18 2020-02-07 센주 세이야꾸 가부시키가이샤 보존 효력을 갖는 브롬페낙 수성 액제 조성물
MX360666B (es) * 2011-05-12 2018-11-13 Foresight Biotherapeutics Inc Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides.
TW202023575A (zh) * 2011-09-16 2020-07-01 美商遠景生物製藥股份有限公司 安定之普維酮—碘組成物
JP6161500B2 (ja) * 2012-10-05 2017-07-12 ロート製薬株式会社 ブロムフェナク含有組成物
US9630909B2 (en) 2013-06-27 2017-04-25 Mylan Laboratories Ltd Process for the preparation of nepafenac
DE102014010694A1 (de) 2014-07-09 2016-01-28 Beuth Hochschule Für Technik Berlin Jod enthaltende pharmazeutische Zusammensetzung mit antimikrobiellen Eigenschaften sowie Verfahren zur Herstellung
KR101961360B1 (ko) * 2015-01-20 2019-03-25 벨로체 바이오파르마 엘엘씨 신규한 요오드포 조성물 및 사용 방법
ITUA20162425A1 (it) * 2016-04-08 2017-10-08 Medivis S R L Composizione oftalmica che comprende PVP-I
CN110114119B (zh) * 2016-10-12 2022-05-31 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
JP6320616B1 (ja) * 2017-08-22 2018-05-09 ヴェローチェ・バイオファーマ・エルエルシー 新規眼科用組成物および使用方法
CA3145888A1 (en) * 2018-07-31 2020-02-06 Isilay KAVADARLI Ophthalmic formulations and uses thereof
EP4467144A4 (en) * 2022-01-21 2026-01-21 Senju Usa Inc AQUEOUS LIQUID FORMULATION
WO2025027498A1 (en) * 2023-08-03 2025-02-06 Alcon Inc. Multidose preservative-free (mdpf) ophthalmic dose delivery with addition of formulation surfactants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
CA1303503C (en) * 1987-11-10 1992-06-16 Marc Plamondon Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
EP0365613B1 (en) * 1988-03-09 1995-05-17 Alcon Laboratories, Inc. Combination of tobramycin and steroids for topical ophthalmic use
US5126127A (en) * 1991-07-16 1992-06-30 Euroceltique, S.A. Stabilized PVP-I solutions
US6328991B1 (en) * 1992-10-21 2001-12-11 John Myhling Composition and method for prevention of sexually transmitted diseases, including aids
WO2004080179A1 (en) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Surface sanitizing compositions with improved antimicrobial performance
US20050095205A1 (en) * 2003-10-31 2005-05-05 Ramesh Krishnamoorthy Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
WO2005046700A1 (ja) * 2003-11-14 2005-05-26 Senju Pharmaceutical Co., Ltd. アミノグリコシド系抗生物質およびブロムフェナクを含有する水溶液製剤
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20070297990A1 (en) * 2006-06-27 2007-12-27 Shah Mandar V Self-preserving composition

Also Published As

Publication number Publication date
NZ625086A (en) 2015-11-27
CN104189911A (zh) 2014-12-10
MX372536B (es) 2020-03-23
DK2291081T3 (da) 2020-08-10
MX2020003159A (es) 2020-07-29
JP6527341B2 (ja) 2019-06-05
CA2727605C (en) 2016-10-04
JP2019052172A (ja) 2019-04-04
MX338674B (es) 2016-04-27
ES2810863T3 (es) 2021-03-09
PE20141185A1 (es) 2014-09-21
CL2010001406A1 (es) 2011-07-08
AU2009258145A1 (en) 2009-12-17
JP2015129139A (ja) 2015-07-16
EP2291081B1 (en) 2020-06-03
CN105944105A (zh) 2016-09-21
PT2291081T (pt) 2020-09-10
CA2727605A1 (en) 2009-12-17
EP2291081A4 (en) 2013-10-23
PL2291081T3 (pl) 2021-01-25
BRPI0913417A2 (pt) 2020-08-04
KR20160045153A (ko) 2016-04-26
KR20110018414A (ko) 2011-02-23
US20130251666A1 (en) 2013-09-26
WO2009151619A1 (en) 2009-12-17
CA2937997A1 (en) 2009-12-17
MX2010013670A (es) 2011-06-24
NZ747878A (en) 2020-07-31
HK1202074A1 (en) 2015-09-18
ECSP11010755A (es) 2011-07-29
CO6341526A2 (es) 2011-11-21
JP2011522891A (ja) 2011-08-04
US20120027716A1 (en) 2012-02-02
EP3777536A1 (en) 2021-02-17
CN102118973A (zh) 2011-07-06
EP2291081A1 (en) 2011-03-09
BRPI0913417B1 (pt) 2021-06-08
JP2021035984A (ja) 2021-03-04
KR20180014859A (ko) 2018-02-09
NZ603346A (en) 2014-05-30

Similar Documents

Publication Publication Date Title
PE20110162A1 (es) Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas
ES2570856T3 (es) Composiciones oftálmicas que contienen una combinación sinérgica de dos polímeros
ES2655435T3 (es) Formulación de disolución rápida de cinacalcet
ES2494442T3 (es) Composiciones adyuvantes que comprenden un agente de isotonicidad no iónico
CL2011000835A1 (es) Compuestos derivados de espiro-oxindol; moduladores de los canales de sodio; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento del dolor, depresion, enfermedades cardiovasculares, respiratorias, psiquiatricas, entre otras.
BR0210139A (pt) Composições farmacêuticas
UY30511A1 (es) Agonistas de ep2
BRPI0408690A (pt) composto, método para tratamento de uma doença, composição farmacêutica, e, uso de um composto
MA29564B1 (fr) Formulation de 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile
CO5700671A2 (es) Formulaciones topicas que comprenden un derivado de 1-n-arilpirazol y una formamidina
PE20121498A1 (es) Composiciones oftalmicas no irritantes de povidona-yodo
AR070025A1 (es) Uso de derivados de 1-amino-alquilciclohexano para el tratamiento del tinnitus coclear y composicion farmaceutica
CL2009000624A1 (es) Composicion farmaceutica oftalmica que comprende un vehiculo que incluye agua, un agente terapeutico que es una prostaglandina, un compuesto de amonio cuaternario polimerico y 0,01-04% p/v de un surfafactante que es aceite vegetal etoxilado y/o hidrogenado, libre de cloruro de benzxalconio; util para tratar glaucoma
BR0310077A (pt) Novos compostos e sua utilização
AR025573A1 (es) Composicion laxante
MA31706B1 (fr) Formulations galéniques de composés organiques
MX2010005013A (es) Composiciones intranasales.
MA53927B1 (fr) Composition pharmaceutique pour une administration par voie orale comprenant un dérivé d'aminopyrimidine ou son sel
JP5202986B2 (ja) コンタクトレンズ装着液
DE602004005564D1 (de) Pharmazeutische Zusammensetzung für Thrombinpeptidderivaten
AR054129A1 (es) Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7
BRPI0417175A (pt) composições, método para produzir essas composições, solução que as compreende e métodos para utilizar as mesmas
JP6449774B2 (ja) 両性イオン性ソフトコンタクトレンズ用眼科用組成物
TR200604349A2 (tr) Aripiprazol içeren farmasötik bileşimler
NO20064808L (no) Orale matrixformuleringer med licarbazepin

Legal Events

Date Code Title Description
FC Refusal