PE20110675A1 - DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASA - Google Patents
DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASAInfo
- Publication number
- PE20110675A1 PE20110675A1 PE2011000203A PE2011000203A PE20110675A1 PE 20110675 A1 PE20110675 A1 PE 20110675A1 PE 2011000203 A PE2011000203 A PE 2011000203A PE 2011000203 A PE2011000203 A PE 2011000203A PE 20110675 A1 PE20110675 A1 PE 20110675A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- methyl
- indol
- amide
- ilmetil
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical class NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1
- -1 C1-C3 ALCOXY Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, Ar ES DE PREFERENCIA 5-TERCBUTIL-3-METANSULFONILAMINO-2-METOXI-FENIL; R1 ES CICLOALQUILO C4-C6 CON 1-2 N, EVENTUALMENTE MONO O DI SUSTITUIDO CON R7; R7 ES ALQUILO C1-C3, HIDROXI, ALCOXI C1-C3, AMINO, ENTRE OTROS; R2 H, HALOGENO, ALQUILO C1-C4; M ES CH, N; T ES ENLACE, ALQUILENO C1-C4 SUSTITUIDO O NO; m ES 0-3; n ES 1-3; p ES 0-3. SON COMPUESTOS PREFERIDOS: (5-TERC-BUTIL-3-METANSULFONILAMINO-2-METOXI-FENIL)-AMIDA DEL ACIDO 1-METIL-7-[4-(1-METIL-PIPERIDIN-4-CARBONIL)-PIPERAZIN-1-ILMETIL]-1H-INDOL-2-CARBOXILICO; [5-TERC-BUTIL-2-METOXI-3-(4-METIL-PIPERAZIN-1-ILMETIL)-FENIL]-AMIDA DEL ACIDO (S)-1-METIL-7-[4-(1-METIL-PIRROLIDIN-2-CARBONIL)-PIPERAZIN-1-ILMETIL]-1H-INDOL-2-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE MAP-QUINASA P38 UTILES EN EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08163526 | 2008-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110675A1 true PE20110675A1 (es) | 2011-09-30 |
Family
ID=40210516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000203A PE20110675A1 (es) | 2008-09-02 | 2009-08-26 | DERIVADOS DE (FENIL)-AMIDA DEL ACIDO 7-(HETEROCICLO-1-ILMETIL))-1H-INDOL-2 CARBOXILICO COMO INHIBIDORES DE p38 MAP-QUINASA |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8686022B2 (es) |
| EP (1) | EP2323980B1 (es) |
| JP (1) | JP5592886B2 (es) |
| KR (1) | KR20110065498A (es) |
| CN (1) | CN102186818B (es) |
| AR (1) | AR073481A1 (es) |
| AT (1) | ATE547402T1 (es) |
| AU (1) | AU2009289379B2 (es) |
| BR (1) | BRPI0918628A2 (es) |
| CA (1) | CA2735770A1 (es) |
| CL (1) | CL2011000424A1 (es) |
| CO (1) | CO6361920A2 (es) |
| DK (1) | DK2323980T3 (es) |
| EA (1) | EA021053B1 (es) |
| EC (1) | ECSP11010844A (es) |
| ES (1) | ES2383340T3 (es) |
| IL (1) | IL211012A0 (es) |
| MA (1) | MA32597B1 (es) |
| MX (1) | MX2011002053A (es) |
| NZ (1) | NZ591227A (es) |
| PE (1) | PE20110675A1 (es) |
| PL (1) | PL2323980T3 (es) |
| TW (1) | TW201014847A (es) |
| UY (1) | UY32081A (es) |
| WO (1) | WO2010026096A1 (es) |
| ZA (1) | ZA201100831B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| MX2011002053A (es) | 2008-09-02 | 2011-03-30 | Boehringer Ingelheim Int | Derivados de (fenil)-amida de acido 7-(piperacina-1-metil)-1h-indo la-2-carboxilico y compuestos relacionados como inhibidores de quinasa map as p38 para el tratamiento de enfermedades respiratorias. |
| EP2331506B1 (de) | 2008-09-02 | 2013-07-03 | Boehringer Ingelheim International GmbH | Neue benzamide, deren herstellung und deren verwendung als arzneimittel |
| TW202415651A (zh) | 2022-07-29 | 2024-04-16 | 日商住友製藥股份有限公司 | 含氮飽和雜環衍生物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2735201A (en) | 1999-12-28 | 2001-07-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| DE102004009238A1 (de) | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
| DE602005019893D1 (de) * | 2004-08-25 | 2010-04-22 | Boehringer Ingelheim Pharma | 2-arylcarbamoyl-indole als zytokinhemmer |
| EP2083816A2 (en) | 2006-10-27 | 2009-08-05 | Brystol-Myers Squibb Company | Heterocyclic amide compounds useful as kinase inhibitors |
| MX2011002053A (es) | 2008-09-02 | 2011-03-30 | Boehringer Ingelheim Int | Derivados de (fenil)-amida de acido 7-(piperacina-1-metil)-1h-indo la-2-carboxilico y compuestos relacionados como inhibidores de quinasa map as p38 para el tratamiento de enfermedades respiratorias. |
| EP2331506B1 (de) | 2008-09-02 | 2013-07-03 | Boehringer Ingelheim International GmbH | Neue benzamide, deren herstellung und deren verwendung als arzneimittel |
-
2009
- 2009-08-26 MX MX2011002053A patent/MX2011002053A/es active IP Right Grant
- 2009-08-26 BR BRPI0918628A patent/BRPI0918628A2/pt not_active IP Right Cessation
- 2009-08-26 WO PCT/EP2009/061025 patent/WO2010026096A1/de not_active Ceased
- 2009-08-26 AT AT09782239T patent/ATE547402T1/de active
- 2009-08-26 KR KR1020117007713A patent/KR20110065498A/ko not_active Withdrawn
- 2009-08-26 PE PE2011000203A patent/PE20110675A1/es not_active Application Discontinuation
- 2009-08-26 NZ NZ591227A patent/NZ591227A/xx not_active IP Right Cessation
- 2009-08-26 CN CN2009801407239A patent/CN102186818B/zh not_active Expired - Fee Related
- 2009-08-26 EA EA201100422A patent/EA021053B1/ru not_active IP Right Cessation
- 2009-08-26 PL PL09782239T patent/PL2323980T3/pl unknown
- 2009-08-26 JP JP2011524373A patent/JP5592886B2/ja active Active
- 2009-08-26 CA CA2735770A patent/CA2735770A1/en not_active Abandoned
- 2009-08-26 AU AU2009289379A patent/AU2009289379B2/en not_active Ceased
- 2009-08-26 ES ES09782239T patent/ES2383340T3/es active Active
- 2009-08-26 DK DK09782239.9T patent/DK2323980T3/da active
- 2009-08-26 EP EP09782239A patent/EP2323980B1/de active Active
- 2009-08-26 US US13/060,504 patent/US8686022B2/en active Active
- 2009-08-31 UY UY0001032081A patent/UY32081A/es not_active Application Discontinuation
- 2009-09-01 TW TW098129416A patent/TW201014847A/zh unknown
- 2009-09-01 AR ARP090103363A patent/AR073481A1/es unknown
-
2011
- 2011-02-01 ZA ZA2011/00831A patent/ZA201100831B/en unknown
- 2011-02-02 IL IL211012A patent/IL211012A0/en unknown
- 2011-02-25 CL CL2011000424A patent/CL2011000424A1/es unknown
- 2011-02-25 EC EC2011010844A patent/ECSP11010844A/es unknown
- 2011-02-28 MA MA33652A patent/MA32597B1/fr unknown
- 2011-03-16 CO CO11032840A patent/CO6361920A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012501310A (ja) | 2012-01-19 |
| EP2323980B1 (de) | 2012-02-29 |
| UY32081A (es) | 2010-03-26 |
| PL2323980T3 (pl) | 2012-10-31 |
| BRPI0918628A2 (pt) | 2015-12-01 |
| WO2010026096A1 (de) | 2010-03-11 |
| EA201100422A1 (ru) | 2011-10-31 |
| NZ591227A (en) | 2013-02-22 |
| US20110269737A1 (en) | 2011-11-03 |
| CN102186818A (zh) | 2011-09-14 |
| MX2011002053A (es) | 2011-03-30 |
| AU2009289379A1 (en) | 2010-03-11 |
| EA021053B1 (ru) | 2015-03-31 |
| CO6361920A2 (es) | 2012-01-20 |
| TW201014847A (en) | 2010-04-16 |
| CL2011000424A1 (es) | 2011-07-15 |
| CA2735770A1 (en) | 2010-03-11 |
| EP2323980A1 (de) | 2011-05-25 |
| US8686022B2 (en) | 2014-04-01 |
| ES2383340T3 (es) | 2012-06-20 |
| KR20110065498A (ko) | 2011-06-15 |
| MA32597B1 (fr) | 2011-09-01 |
| ATE547402T1 (de) | 2012-03-15 |
| ECSP11010844A (es) | 2011-03-31 |
| ZA201100831B (en) | 2011-10-26 |
| JP5592886B2 (ja) | 2014-09-17 |
| AR073481A1 (es) | 2010-11-10 |
| AU2009289379B2 (en) | 2014-03-27 |
| CN102186818B (zh) | 2013-10-02 |
| IL211012A0 (en) | 2011-04-28 |
| DK2323980T3 (da) | 2012-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |