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MX2011012240A - Compuestos heterociclicos antivirales. - Google Patents

Compuestos heterociclicos antivirales.

Info

Publication number
MX2011012240A
MX2011012240A MX2011012240A MX2011012240A MX2011012240A MX 2011012240 A MX2011012240 A MX 2011012240A MX 2011012240 A MX2011012240 A MX 2011012240A MX 2011012240 A MX2011012240 A MX 2011012240A MX 2011012240 A MX2011012240 A MX 2011012240A
Authority
MX
Mexico
Prior art keywords
antiviral compounds
heterocyclic antiviral
heterocyclic
compounds
hepatitis
Prior art date
Application number
MX2011012240A
Other languages
English (en)
Inventor
Elbert Chin
Jim Li
Alfred Sui-Ting Lui
Francisco Xavier Talamas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2011012240A publication Critical patent/MX2011012240A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos que tienen la fórmula I, (ver fórmula (I)) en la que R1, R2, R3b, R4a, R4b, R4C y R5 tienen los significados aquí definidos, son inhibidores de la polimerasa NS5b del virus de la hepatitis C. Se describen también composiciones y métodos para tratar una infección del HCV y para inhibir la replicación del HCV.
MX2011012240A 2009-05-20 2010-05-17 Compuestos heterociclicos antivirales. MX2011012240A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17985709P 2009-05-20 2009-05-20
PCT/EP2010/056686 WO2010133528A1 (en) 2009-05-20 2010-05-17 Heterocyclic antiviral compounds

Publications (1)

Publication Number Publication Date
MX2011012240A true MX2011012240A (es) 2011-12-08

Family

ID=42488524

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012240A MX2011012240A (es) 2009-05-20 2010-05-17 Compuestos heterociclicos antivirales.

Country Status (14)

Country Link
US (1) US20100297073A1 (es)
EP (1) EP2432554A1 (es)
JP (1) JP2012527420A (es)
KR (1) KR20120024784A (es)
CN (1) CN102448548A (es)
AR (1) AR078412A1 (es)
AU (1) AU2010251272A1 (es)
BR (1) BRPI1010900A2 (es)
CA (1) CA2761279A1 (es)
IL (1) IL216026A0 (es)
MX (1) MX2011012240A (es)
SG (1) SG176163A1 (es)
TW (1) TW201100404A (es)
WO (1) WO2010133528A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201400957UA (en) * 2009-03-25 2014-09-26 Abbott Lab Antiviral Compounds And Uses Thereof
CA2815537A1 (en) 2010-10-26 2012-05-03 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus
TWI566701B (zh) * 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
WO2019170543A1 (en) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
CN108822111A (zh) * 2018-08-02 2018-11-16 温州医科大学 一种5-（2-乙氧基苯基）-1-甲基-3-丙基-1H-吡唑并[4,3-d]嘧啶-7-酮的制备方法
EP4077310B1 (en) 2019-12-19 2024-05-01 Université de Strasbourg Sigma-1 receptor ligands and uses thereof
WO2024111390A1 (ja) * 2022-11-22 2024-05-30 学校法人帝京大学 化合物及びその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1292310A1 (en) * 2000-05-10 2003-03-19 SmithKline Beecham Corporation Novel anti-infectives
AR036081A1 (es) * 2001-06-07 2004-08-11 Smithkline Beecham Corp Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos
AU2002365198A1 (en) * 2001-10-30 2003-07-30 Smithkline Beecham Corporation Novel anti-infectives
KR20050065670A (ko) * 2002-11-01 2005-06-29 아보트 러보러터리즈 항감염제
JP2007530600A (ja) * 2004-03-31 2007-11-01 モナシュ ユニバーシティ 抗ウイルス剤
AU2009273327A1 (en) * 2008-07-23 2010-01-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds

Also Published As

Publication number Publication date
IL216026A0 (en) 2012-01-31
AU2010251272A1 (en) 2011-12-15
SG176163A1 (en) 2011-12-29
JP2012527420A (ja) 2012-11-08
US20100297073A1 (en) 2010-11-25
AR078412A1 (es) 2011-11-09
BRPI1010900A2 (pt) 2016-03-15
CN102448548A (zh) 2012-05-09
TW201100404A (en) 2011-01-01
EP2432554A1 (en) 2012-03-28
WO2010133528A1 (en) 2010-11-25
CA2761279A1 (en) 2010-11-25
KR20120024784A (ko) 2012-03-14

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal