PE20091831A1 - Derivados de piperidina como agonistas de receptores muscarinicos - Google Patents
Derivados de piperidina como agonistas de receptores muscarinicosInfo
- Publication number
- PE20091831A1 PE20091831A1 PE2009000610A PE2009000610A PE20091831A1 PE 20091831 A1 PE20091831 A1 PE 20091831A1 PE 2009000610 A PE2009000610 A PE 2009000610A PE 2009000610 A PE2009000610 A PE 2009000610A PE 20091831 A1 PE20091831 A1 PE 20091831A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- integer
- muscarinal
- agonists
- receptors
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- -1 CYCLOHEXYL Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN DERIVADO DE PIPERIDINA DE FORMULA (I), DONDE R1 ES FLUORO, CICLOALQUILO C3-C7, ALQUILO C1-C7, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R2 ES HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C7, ALQUILO C1-C6 HALOGENADO, ENTRE OTROS; R3 ES HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C7, CN, ENTRE OTROS; R4 ES H, ALQUILO C1-C6 O HALOALQUILO C1-C6; q ES UN ENTERO DE 1 A 4; p ES 2, 3 O 4; s ES 0 O UN ENTERO DE 1 A 4; t ES 0 O UN ENTERO DE 1 A 4; n ES 0 O UN ENTERO DE 1 A 4; m ES 0 O UN ENTERO DE 1 A 4; Y ES -CR5R6-, -O- O -S-; X ES -CR5R6-, -NR7-, -O- O -S-; R5, R6 Y R7 SON H, ALQUILO C1-C6, ALQUENILO C2-C6 O ALQUILO C1-C6 HALOGENADO. SON COMPUESTOS PREFERIDOS: (4aR, 8aS)-1-(1-(4-(PROPOXIMETIL)CICLOHEXIL)PIPERIDIN-4-IL)OCTAHIDROQUINAZOLIN-2(1H)-ONA, (4aR,8aS)-1-(1-(4-(ISOPROPOXIMETIL) CICLOHEXIL)PIPERIDIN-4-IL)OCTAHIDROQUINAZOLIN-2(1H)-ONA, (4aR,8aS)-1-(1-(4-(PROPOXICICLOHEXIL)PIPERIDIN-4-IL)OCTAHIDROQUINAZOLIN-2(1H)-ONA. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE RECEPTORES MUSCARINICOS Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, LA ENFERMEDAD DE ALZHEIMER, ESQUIZOFRENIA, ANSIEDAD ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5034308P | 2008-05-05 | 2008-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091831A1 true PE20091831A1 (es) | 2009-12-31 |
Family
ID=41257503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000610A PE20091831A1 (es) | 2008-05-05 | 2009-05-05 | Derivados de piperidina como agonistas de receptores muscarinicos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090275574A1 (es) |
| EP (1) | EP2285798A4 (es) |
| JP (1) | JP2011519922A (es) |
| KR (1) | KR20110011654A (es) |
| CN (1) | CN102083812A (es) |
| AR (1) | AR071618A1 (es) |
| AU (1) | AU2009244944A1 (es) |
| BR (1) | BRPI0912537A2 (es) |
| CA (1) | CA2723679A1 (es) |
| MX (1) | MX2010011841A (es) |
| PE (1) | PE20091831A1 (es) |
| RU (1) | RU2010143984A (es) |
| TW (1) | TW200951119A (es) |
| UY (1) | UY31805A (es) |
| WO (1) | WO2009136850A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200813018A (en) * | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| TW200815405A (en) * | 2006-06-09 | 2008-04-01 | Astrazeneca Ab | Novel compounds |
| ES2613631T3 (es) * | 2010-12-22 | 2017-05-25 | Purdue Pharma L.P. | Compuestos de piperidina de tipo quinoxalina sustituidos con fósforo y usos de los mismos |
| WO2015138237A1 (en) | 2014-03-10 | 2015-09-17 | Mary Kay Inc. | Skin lightening compositions |
| JP2022524861A (ja) | 2019-03-15 | 2022-05-10 | バイエル・アクチエンゲゼルシヤフト | 具体的に置換された３－フェニル－５－スピロシクロペンチル－３－ピロリン－２－オン類及び除草剤としてのその使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515008A (ja) * | 1994-10-27 | 2002-05-21 | メルク エンド カンパニー インコーポレーテッド | ムスカリン・アンタゴニスト |
| CA2347506C (en) * | 1998-10-16 | 2009-06-23 | Sumitomo Pharmaceuticals Co., Ltd. | Quinazolinone derivatives |
| SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
| US8067603B2 (en) * | 2003-09-25 | 2011-11-29 | Solvay Pharmaceuticals B.V. | Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors |
| JP2006188466A (ja) * | 2005-01-07 | 2006-07-20 | Dainippon Sumitomo Pharma Co Ltd | 過活動膀胱治療薬としてのキナゾリノン誘導体 |
| GB0605784D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| TW200813018A (en) * | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
-
2009
- 2009-04-30 US US12/432,818 patent/US20090275574A1/en not_active Abandoned
- 2009-05-04 BR BRPI0912537A patent/BRPI0912537A2/pt not_active IP Right Cessation
- 2009-05-04 RU RU2010143984/04A patent/RU2010143984A/ru not_active Application Discontinuation
- 2009-05-04 WO PCT/SE2009/050477 patent/WO2009136850A1/en not_active Ceased
- 2009-05-04 MX MX2010011841A patent/MX2010011841A/es not_active Application Discontinuation
- 2009-05-04 CA CA2723679A patent/CA2723679A1/en not_active Abandoned
- 2009-05-04 EP EP09742932A patent/EP2285798A4/en not_active Withdrawn
- 2009-05-04 CN CN2009801261650A patent/CN102083812A/zh active Pending
- 2009-05-04 TW TW098114745A patent/TW200951119A/zh unknown
- 2009-05-04 AR ARP090101597A patent/AR071618A1/es unknown
- 2009-05-04 JP JP2011508444A patent/JP2011519922A/ja active Pending
- 2009-05-04 AU AU2009244944A patent/AU2009244944A1/en not_active Abandoned
- 2009-05-04 KR KR1020107027223A patent/KR20110011654A/ko not_active Withdrawn
- 2009-05-04 UY UY0001031805A patent/UY31805A/es unknown
- 2009-05-05 PE PE2009000610A patent/PE20091831A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2285798A1 (en) | 2011-02-23 |
| AR071618A1 (es) | 2010-06-30 |
| EP2285798A4 (en) | 2013-01-02 |
| BRPI0912537A2 (pt) | 2015-10-13 |
| RU2010143984A (ru) | 2012-06-20 |
| KR20110011654A (ko) | 2011-02-08 |
| AU2009244944A1 (en) | 2009-11-12 |
| UY31805A (es) | 2010-01-05 |
| JP2011519922A (ja) | 2011-07-14 |
| TW200951119A (en) | 2009-12-16 |
| US20090275574A1 (en) | 2009-11-05 |
| MX2010011841A (es) | 2010-11-26 |
| WO2009136850A1 (en) | 2009-11-12 |
| CA2723679A1 (en) | 2009-11-12 |
| CN102083812A (zh) | 2011-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |