CY1114991T1 - Παραγωγα αζετιδινων, ο τροπος παρασκευης τους και η εφαρμογη τους στη θεραπευτικη - Google Patents
Παραγωγα αζετιδινων, ο τροπος παρασκευης τους και η εφαρμογη τους στη θεραπευτικηInfo
- Publication number
- CY1114991T1 CY1114991T1 CY20131101118T CY131101118T CY1114991T1 CY 1114991 T1 CY1114991 T1 CY 1114991T1 CY 20131101118 T CY20131101118 T CY 20131101118T CY 131101118 T CY131101118 T CY 131101118T CY 1114991 T1 CY1114991 T1 CY 1114991T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl group
- alkyl
- group
- optionally substituted
- hydrogen atom
- Prior art date
Links
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 2
- IADUEWIQBXOCDZ-UHFFFAOYSA-N (2S)-azetidine-2-carboxylic acid Natural products OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 abstract 1
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 abstract 1
- YHIIJNLSGULWAA-UHFFFAOYSA-N 1,4-thiazinane 1-oxide Chemical compound O=S1CCNCC1 YHIIJNLSGULWAA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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Abstract
Η παρούσα εφεύρεση έχει ως αντικείμενο τις ενώσεις που ανταποκρίνονται στον τύπο (Ι) όπου: Το R δηλώνει μια ομάδα (C1-C6)αλκυλίου, αλο(C1-C6)αλκυλίου, το R´ δηλώνει μια ομάδα ΝR4R5, ΟR8. Το Α και το Β, εάν υπάρχουν αντιπροσωπεύουν ανεξάρτητα το ένα από το άλλο, ένα ή δύο άτομα άνθρακα, με τα άτομα αυτά του άνθρακα να αντικαθίστανται από ένα ή περισσότερα υδρογόνα, ομάδες (C1-C6)αλκυλίου, με την ή τις ομάδες (C1-C6)αλκυλίου να μπορούν ενδεχομένως να υποκατασταθούν, το Α+Β αντιπροσωπεύουν κατά μέγιστο δύο άνθρακες, το R1 αντιπροσωπεύει ένα άτομο υδρογόνου ή μια ομάδα (C1-C6)αλκυλίου, το R2 και το R3 αντιπροσωπεύουν ανεξάρτητα το ένα από το άλλο, ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλίου, με την ομάδα (C1-C6)αλκυλίου να μπορεί ενδεχομένως να υποκατασταθεί, το R4 και το R5 δηλώνουν ανεξάρτητα το ένα από το άλλο, ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλίου, ή σχηματίζουν, με το άτομο αζώτου που τα φέρει, έναν ετερόκυκλο του τύπου αζετιδίνης, πυρρολιδίνης, πιπεριδίνης, αζεπάνης, πιπεραζίνης, ομοπιπεραζίνης, μορφολίνης, θειομορφολίνης, θειομορφολίνο S-οξειδίου, θειομορφολινο S-διοξειδίου, με τον ετερόκυκλο αυτό να μπορεί ενδεχομένως να υποκατασταθεί από μια ομάδα (Ci-C6)αλκυλίου. Το R6 και το R7 δηλώνουν το κάθε ένα μια ομάδα φαινυλίου, ενδεχομένως υποκαθιστούμενη, το Υ δηλώνει ένα άτομο υδρογόνου, ένα αλογόνο, μια ομάδα (C1-C6)αλκυλίου, αλο(C1-C6)αλκυλίου, (d-C6)αλκοξέος, αλο(C1-C6)αλκοξέος, (C1-C6)άλκυλοS(O)p ή κυανό. Το R8 είναι ένα άτομο υδρογόνου, μια ομάδα (d-C6)αλκυλίου, μια ομάδα αλο(C1-C6)αλκυλίου, μια ομάδα αλλυλίου, μια ομάδα φαινυλο(C1-C6)αλκυλίου, με την ομάδα φαινυλίου να μπορεί ενδεχομένως να υποκατασταθεί από 1 ή 2 ομάδες Ο-μεθυλίου. Το p δηλώνει έναν ακέραιο αριθμό που επιλέγεται ανάμεσα από τα 0, 1 ή 2, στην κατάσταση βάσης ή στο άλας προσθήκης σε ένα οξύ ή σε μια βάση. Διαδικασία
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708830A FR2925051B1 (fr) | 2007-12-18 | 2007-12-18 | Derives d'azetidines,leur preparation et leur application en therapeutique |
| FR0802492A FR2930941B1 (fr) | 2008-05-06 | 2008-05-06 | Derives d'azetidines, leur preparation et leur application en therapeutique |
| EP08872952.0A EP2234966B1 (fr) | 2007-12-18 | 2008-12-16 | Derives d'azetidines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114991T1 true CY1114991T1 (el) | 2016-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131101118T CY1114991T1 (el) | 2007-12-18 | 2013-12-11 | Παραγωγα αζετιδινων, ο τροπος παρασκευης τους και η εφαρμογη τους στη θεραπευτικη |
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| Country | Link |
|---|---|
| US (2) | US8445478B2 (el) |
| EP (1) | EP2234966B1 (el) |
| JP (1) | JP5460614B2 (el) |
| KR (1) | KR20100098563A (el) |
| CN (1) | CN101945852B (el) |
| AR (1) | AR069700A1 (el) |
| AU (1) | AU2008351943B2 (el) |
| BR (1) | BRPI0822054A2 (el) |
| CA (1) | CA2709863A1 (el) |
| CL (1) | CL2008003780A1 (el) |
| CO (1) | CO6290755A2 (el) |
| CY (1) | CY1114991T1 (el) |
| DK (1) | DK2234966T3 (el) |
| EA (1) | EA019315B1 (el) |
| ES (1) | ES2439258T3 (el) |
| HR (1) | HRP20131168T1 (el) |
| IL (1) | IL206420A (el) |
| MA (1) | MA32019B1 (el) |
| PA (1) | PA8808101A1 (el) |
| PE (1) | PE20091270A1 (el) |
| PL (1) | PL2234966T3 (el) |
| PT (1) | PT2234966E (el) |
| SI (1) | SI2234966T1 (el) |
| TW (1) | TW200930360A (el) |
| UY (1) | UY31548A1 (el) |
| WO (1) | WO2009106708A2 (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| FR2946650B1 (fr) * | 2009-06-16 | 2011-08-19 | Sanofi Aventis | Esters derives d'azetidines, leur preparation et leur application en therapeutique. |
| US9440948B2 (en) | 2010-09-03 | 2016-09-13 | University Of Florida Research Foundation, Inc. | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
| GB201321601D0 (en) * | 2013-12-06 | 2014-01-22 | Canbex Therapeutics Ltd | Modulator |
| US11003343B2 (en) * | 2014-01-06 | 2021-05-11 | Lett.rs LLC | Electronic personal signature generation and distribution for personal communication |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1254115A2 (en) * | 2000-02-11 | 2002-11-06 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| FR2805817B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| ES2301833T3 (es) * | 2002-07-29 | 2008-07-01 | Hoffmann La Roche | Derivados de benzodioxol. |
| ATE453620T1 (de) * | 2003-05-01 | 2010-01-15 | Vernalis Res Ltd | Azetidincarboxamid-derivate zur verwendung zur behandlung von cb1-rezeptor-vermittelten krankheiten |
| PE20071092A1 (es) * | 2005-12-08 | 2007-12-10 | Aventis Pharma Inc | Composicion farmaceutica que comprende un antagonista de cb1 y un agente antisicotico |
| EP1993560B1 (en) * | 2006-03-10 | 2011-12-28 | Jenrin Discovery | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity |
-
2008
- 2008-12-16 AR ARP080105459A patent/AR069700A1/es unknown
- 2008-12-16 WO PCT/FR2008/001748 patent/WO2009106708A2/fr not_active Ceased
- 2008-12-16 PE PE2008002084A patent/PE20091270A1/es not_active Application Discontinuation
- 2008-12-16 PT PT88729520T patent/PT2234966E/pt unknown
- 2008-12-16 JP JP2010538830A patent/JP5460614B2/ja not_active Expired - Fee Related
- 2008-12-16 SI SI200831115T patent/SI2234966T1/sl unknown
- 2008-12-16 HR HRP20131168AT patent/HRP20131168T1/hr unknown
- 2008-12-16 DK DK08872952.0T patent/DK2234966T3/da active
- 2008-12-16 EA EA201070758A patent/EA019315B1/ru not_active IP Right Cessation
- 2008-12-16 AU AU2008351943A patent/AU2008351943B2/en not_active Ceased
- 2008-12-16 KR KR1020107015774A patent/KR20100098563A/ko not_active Ceased
- 2008-12-16 ES ES08872952.0T patent/ES2439258T3/es active Active
- 2008-12-16 PL PL08872952T patent/PL2234966T3/pl unknown
- 2008-12-16 EP EP08872952.0A patent/EP2234966B1/fr active Active
- 2008-12-16 BR BRPI0822054-9A patent/BRPI0822054A2/pt not_active IP Right Cessation
- 2008-12-16 CN CN200880126985.5A patent/CN101945852B/zh not_active Expired - Fee Related
- 2008-12-16 CA CA2709863A patent/CA2709863A1/fr not_active Abandoned
- 2008-12-17 PA PA20088808101A patent/PA8808101A1/es unknown
- 2008-12-17 CL CL2008003780A patent/CL2008003780A1/es unknown
- 2008-12-18 UY UY31548A patent/UY31548A1/es not_active Application Discontinuation
- 2008-12-18 TW TW097149442A patent/TW200930360A/zh unknown
-
2010
- 2010-06-16 IL IL206420A patent/IL206420A/en not_active IP Right Cessation
- 2010-06-18 CO CO10073795A patent/CO6290755A2/es not_active Application Discontinuation
- 2010-06-18 US US12/818,274 patent/US8445478B2/en not_active Expired - Fee Related
- 2010-07-14 MA MA33018A patent/MA32019B1/fr unknown
-
2013
- 2013-04-23 US US13/868,602 patent/US20130237513A1/en not_active Abandoned
- 2013-12-11 CY CY20131101118T patent/CY1114991T1/el unknown
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