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PE20091676A1 - Preparacion selectiva de pirimidinas sustituidas - Google Patents

Preparacion selectiva de pirimidinas sustituidas

Info

Publication number
PE20091676A1
PE20091676A1 PE2009000401A PE2009000401A PE20091676A1 PE 20091676 A1 PE20091676 A1 PE 20091676A1 PE 2009000401 A PE2009000401 A PE 2009000401A PE 2009000401 A PE2009000401 A PE 2009000401A PE 20091676 A1 PE20091676 A1 PE 20091676A1
Authority
PE
Peru
Prior art keywords
precipitate
preparation
group
sec
pyrimidines
Prior art date
Application number
PE2009000401A
Other languages
English (en)
Inventor
Adil Duran
Stefan Goepper
Joerg Halmer
Michael Konrad
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20091676A1 publication Critical patent/PE20091676A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

REFERIDA A UN PROCEDIMIENO DE PREPARACION DEL COMPUESTO III, DONDE X2 ES UN GRUPO SALIENTE; R1 Y R2 SON CADA UNO H, GRUPO AROMATICO, GRUPO ALIFATICO QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA I, DONDE X1 ES UN GRUPO SALIENTE, CON UNA AMINA [HN(R1)R2] EN PRESENCIA DE UNA BASE AUXILIAR NO NUCLEOFILICA TAL COMO N-N-DIISOPROPIL-ETILAMINA EN UN DISOLVENTE O MEZCLA DE DISOLVENTES SELECCIONADOS DE ALCOHOLES NO NUCLEOFILICOS TALES COMO TERC-BUTANOL, NEOPENTANOL, SEC-PENTANOL Y ALCOHOL SEC-ISOAMILICO; B) PRECIPITAR EL COMPUESTO III DE LA MEZCLA DE RECCION; C) SUSPENDER OPCIONALEMTNE EL PRECIPITADO EN AGUA; C) RECOGER EL PRECIPITADO, LAVAR EL PRECIPITADO Y SECAR. DICHA REACCION SE LLEVA A CABO A UNA TEMPERATURA DE RECCION DE APROXIMADAMENTE 40-80 ºC. MEDIANTE DICHO PROCESO SE OBTIENE DERIVADOS DE 2-AMINO-5-TRIFLUOROMETILPIRIMIDINA QUE PUEDE UTILIZARSE PARA LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS
PE2009000401A 2008-03-20 2009-03-18 Preparacion selectiva de pirimidinas sustituidas PE20091676A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08153122 2008-03-20

Publications (1)

Publication Number Publication Date
PE20091676A1 true PE20091676A1 (es) 2009-11-12

Family

ID=40933625

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000401A PE20091676A1 (es) 2008-03-20 2009-03-18 Preparacion selectiva de pirimidinas sustituidas

Country Status (9)

Country Link
US (2) US8334383B2 (es)
EP (1) EP2268622A1 (es)
JP (2) JP5330497B2 (es)
AR (1) AR071005A1 (es)
CA (1) CA2718892A1 (es)
PE (1) PE20091676A1 (es)
TW (1) TW200944509A (es)
UY (1) UY31714A (es)
WO (1) WO2009115587A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2718858A1 (en) 2008-03-20 2009-09-24 Boehringer Ingelheim International Gmbh Selective synthesis of substituted pyrimidines
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
US8729265B2 (en) 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) * 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
JP6391988B2 (ja) * 2014-05-21 2018-09-19 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体
CN108440499A (zh) * 2018-03-22 2018-08-24 盐城师范学院 一种色瑞替尼及其关键中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6262A (ja) 1986-03-05 1987-01-06 Ishihara Sangyo Kaisha Ltd ベンゾイルウレア系化合物の製造方法
EP1663991B1 (en) 2003-09-05 2007-01-10 Pfizer Products Inc. Selective synthesis of cf3-substituted pyrimidines
JP2008540391A (ja) * 2005-05-05 2008-11-20 アストラゼネカ アクチボラグ ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用
AU2006327871A1 (en) * 2005-12-21 2007-06-28 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
EP2007754A1 (en) * 2006-04-10 2008-12-31 Boehringer Ingelheim International GmbH 2, 4-diaminopyrimidine derivatives and their use for the treatment of cancer
PE20080068A1 (es) * 2006-05-15 2008-03-17 Boehringer Ingelheim Int Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
NZ580372A (en) * 2007-04-18 2012-01-12 Pfizer Prod Inc Pyrimidine and triazine derivatives including a sulfonamide group for the treatment of abnormal cell growth such as cancer
CA2718858A1 (en) 2008-03-20 2009-09-24 Boehringer Ingelheim International Gmbh Selective synthesis of substituted pyrimidines
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
US8729265B2 (en) * 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines

Also Published As

Publication number Publication date
EP2268622A1 (en) 2011-01-05
AR071005A1 (es) 2010-05-19
US20110077403A1 (en) 2011-03-31
WO2009115587A1 (en) 2009-09-24
US20130079519A1 (en) 2013-03-28
JP2013237687A (ja) 2013-11-28
JP5330497B2 (ja) 2013-10-30
US8334383B2 (en) 2012-12-18
CA2718892A1 (en) 2009-09-24
UY31714A (es) 2009-11-10
JP2011515375A (ja) 2011-05-19
TW200944509A (en) 2009-11-01

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