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AR066430A1 - Proceso para preparar inhibidores de aromatasa y forma cristalina de exemestano - Google Patents

Proceso para preparar inhibidores de aromatasa y forma cristalina de exemestano

Info

Publication number
AR066430A1
AR066430A1 ARP080101880A ARP080101880A AR066430A1 AR 066430 A1 AR066430 A1 AR 066430A1 AR P080101880 A ARP080101880 A AR P080101880A AR P080101880 A ARP080101880 A AR P080101880A AR 066430 A1 AR066430 A1 AR 066430A1
Authority
AR
Argentina
Prior art keywords
exemestane
prepare
crystal form
aromatase inhibitors
formula
Prior art date
Application number
ARP080101880A
Other languages
English (en)
Inventor
Weiyu Chen
Shu-Ping Chen
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of AR066430A1 publication Critical patent/AR066430A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso para preparar un inhibidor de aromatasa de la formula (1) en donde cada uno de R1, R2, R3, y R4 es de modo independiente hidrogeno, halogeno o alquilo C1-6, que comprende hacer reaccionar Un compuesto de la formula (2) con un ácido enpresencia de un solvente apropiado. También se describe una nueva forma cristalina de exemestano.
ARP080101880A 2007-05-04 2008-05-02 Proceso para preparar inhibidores de aromatasa y forma cristalina de exemestano AR066430A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92762607P 2007-05-04 2007-05-04

Publications (1)

Publication Number Publication Date
AR066430A1 true AR066430A1 (es) 2009-08-19

Family

ID=39940021

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101880A AR066430A1 (es) 2007-05-04 2008-05-02 Proceso para preparar inhibidores de aromatasa y forma cristalina de exemestano

Country Status (14)

Country Link
US (1) US20080275259A1 (es)
EP (1) EP2142561B9 (es)
JP (1) JP5282084B2 (es)
KR (1) KR101446825B1 (es)
CN (1) CN101730705B (es)
AR (1) AR066430A1 (es)
AU (1) AU2008248222B2 (es)
CA (1) CA2686312C (es)
DK (1) DK2142561T3 (es)
ES (1) ES2428166T3 (es)
NZ (1) NZ580956A (es)
PL (1) PL2142561T3 (es)
TW (1) TWI354675B (es)
WO (1) WO2008137048A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070951A1 (en) 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
CN105061539A (zh) * 2015-08-18 2015-11-18 齐鲁安替（临邑）制药有限公司 一种依西美坦的新晶型及其制备工艺
CN106928303B (zh) * 2017-03-30 2018-11-23 绍兴文理学院 一种螺环化合物及其制备方法和应用
CN106928302B (zh) * 2017-03-30 2019-02-22 浙江医药股份有限公司昌海生物分公司 一种雄烯二酮衍生物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
NL122154C (es) * 1963-10-18
JPS5614675B2 (es) * 1973-06-16 1981-04-06
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
DD258820A1 (de) 1986-06-13 1988-08-03 Adw Ddr Verfahren zur herstellung von 6beta-hydroxy-methyl-androsta-1,4-dien-3,17-dion
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
DD264220A1 (de) * 1987-09-23 1989-01-25 Adw Ddr Verfahren zur herstellung von 6-methylen-androsta-1,4-dien-3,17-dion
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
AU2002331916B2 (en) * 2001-10-03 2008-07-24 Merck Sharp & Dohme Corp. Androstane 17-beta-carboxamides as androgen receptor modulators
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
JP4970932B2 (ja) * 2003-03-11 2012-07-11 トロフォ コレスト−４−エン−３−オンの誘導体の医薬としての使用、これらを含む医薬組成物、新規誘導体及びそれらの製造方法
WO2005070951A1 (en) * 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same

Also Published As

Publication number Publication date
TW200904823A (en) 2009-02-01
EP2142561A4 (en) 2010-04-21
EP2142561B9 (en) 2014-02-19
JP2010526141A (ja) 2010-07-29
EP2142561A1 (en) 2010-01-13
US20080275259A1 (en) 2008-11-06
TWI354675B (en) 2011-12-21
CA2686312A1 (en) 2008-11-13
WO2008137048A1 (en) 2008-11-13
AU2008248222A1 (en) 2008-11-13
CN101730705B (zh) 2012-10-03
NZ580956A (en) 2012-08-31
EP2142561B1 (en) 2013-06-26
CA2686312C (en) 2013-06-25
AU2008248222A8 (en) 2009-12-24
JP5282084B2 (ja) 2013-09-04
CN101730705A (zh) 2010-06-09
KR20100028543A (ko) 2010-03-12
AU2008248222B2 (en) 2013-03-28
PL2142561T3 (pl) 2013-11-29
DK2142561T3 (da) 2013-09-02
ES2428166T3 (es) 2013-11-06
KR101446825B1 (ko) 2014-10-07

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