PE20090901A1 - Procedimiento para preparar derivados de 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepina - Google Patents
Procedimiento para preparar derivados de 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepinaInfo
- Publication number
- PE20090901A1 PE20090901A1 PE2008001362A PE2008001362A PE20090901A1 PE 20090901 A1 PE20090901 A1 PE 20090901A1 PE 2008001362 A PE2008001362 A PE 2008001362A PE 2008001362 A PE2008001362 A PE 2008001362A PE 20090901 A1 PE20090901 A1 PE 20090901A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- tetrahydro
- oxo
- preparing
- Prior art date
Links
- HPOQPYOUJYHQND-UHFFFAOYSA-N 1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one Chemical class N1C(=O)NCCC2=CC=CC=C21 HPOQPYOUJYHQND-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- BMTAFVWTTFSTOG-UHFFFAOYSA-N Butylate Chemical compound CCSC(=O)N(CC(C)C)CC(C)C BMTAFVWTTFSTOG-UHFFFAOYSA-N 0.000 abstract 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 1
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical group C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- -1 PIPERIDINYL Chemical class 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 150000003852 triazoles Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDO A UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPINA DE FORMULA (I), DONDE R1.1 ES CH3, CF3, NR1.1.1R1.1.2 O PIPERIDINILO; R1.1.1, R1.1.2, R1.2.1 Y R1.2.2 SON CADA UNO H, ALQUILO(C1-C6), O-BENCILO O O-TERC-BUTILO; R1.2 ES NR1.2.1R1.2.2; R1.3 ES CH3, CF3, F, CL O BR; R2 ES ALQUILO C1-6 QUE COMPRENDE LOS PASOS DE: (A) COPULAR UN COMPUESTO (III), EN LA QUE R1.1, R1.2 Y R1.3 SE DEFINEN AL COMIENZO, CON UN COMPUESTO DE FORMULA (IV), EN DONDE R3 ES IMIDAZOL O TRIAZOL EN UN DISOLVENTE TAL COMO ALCOHOL TERC-AMILICO EN PRESENCIA DE UNA BASE TAL COMO TERC BUTILATO DE POTASIO; (B) HACER REACCIONAR EL COMPUESTO (II) OBTENIDO DEL PASO (A) CON UN COMPUESTO DE FORMULA V, DONDE R2 SE HA DEFINIDO ANTERIORMENTE Y EVENTUALMENTE (C) RECRISTALIZAR EN UN DISOLVENTE ADECUADO EL SOLIDO OBTENIDO EN EL PASO (B). EL COMPUESTO DE FORMULA (I) TIENE ACTIVIDAD ANTAGONISTA DEL CGRP (PEPTIDO RELACIONADO DE LA CALCITOCINA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007038250A DE102007038250A1 (de) | 2007-08-13 | 2007-08-13 | Neues Herstellverfahren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090901A1 true PE20090901A1 (es) | 2009-08-06 |
Family
ID=39877761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001362A PE20090901A1 (es) | 2007-08-13 | 2008-08-11 | Procedimiento para preparar derivados de 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8222402B2 (es) |
| EP (1) | EP2195294A1 (es) |
| JP (1) | JP2010535837A (es) |
| KR (1) | KR20100053651A (es) |
| CN (1) | CN101821237A (es) |
| AR (1) | AR068806A1 (es) |
| AU (1) | AU2008288429A1 (es) |
| BR (1) | BRPI0815498A2 (es) |
| CA (1) | CA2696205A1 (es) |
| CL (1) | CL2008002376A1 (es) |
| DE (1) | DE102007038250A1 (es) |
| MX (1) | MX2010001600A (es) |
| PE (1) | PE20090901A1 (es) |
| TW (1) | TW200916461A (es) |
| UY (1) | UY31283A1 (es) |
| WO (1) | WO2009021942A1 (es) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07501063A (ja) * | 1991-11-14 | 1995-02-02 | グラクソ、グループ、リミテッド | フィブリノーゲン依存性血小板凝集阻害剤としてのピペリジン酢酸誘導体 |
| NZ319673A (en) * | 1995-10-17 | 2000-06-23 | Astra Pharma Prod | Quinazoline compounds for inflammatory disorders such rheumatoid arthritis or osteoarthritis |
| CN1209063A (zh) * | 1995-12-29 | 1999-02-24 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| DE10250080A1 (de) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102004015723A1 (de) * | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102004018795A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102005038831A1 (de) * | 2005-08-17 | 2007-02-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102007038251A1 (de) * | 2007-08-13 | 2009-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Herstellverfahren |
-
2007
- 2007-08-13 DE DE102007038250A patent/DE102007038250A1/de not_active Withdrawn
-
2008
- 2008-08-11 UY UY31283A patent/UY31283A1/es not_active Application Discontinuation
- 2008-08-11 PE PE2008001362A patent/PE20090901A1/es not_active Application Discontinuation
- 2008-08-12 CA CA2696205A patent/CA2696205A1/en not_active Abandoned
- 2008-08-12 BR BRPI0815498-8A2A patent/BRPI0815498A2/pt not_active Application Discontinuation
- 2008-08-12 JP JP2010520553A patent/JP2010535837A/ja active Pending
- 2008-08-12 AR ARP080103512A patent/AR068806A1/es unknown
- 2008-08-12 MX MX2010001600A patent/MX2010001600A/es not_active Application Discontinuation
- 2008-08-12 KR KR1020107005404A patent/KR20100053651A/ko not_active Withdrawn
- 2008-08-12 US US12/672,093 patent/US8222402B2/en active Active
- 2008-08-12 CN CN200880111399A patent/CN101821237A/zh active Pending
- 2008-08-12 CL CL2008002376A patent/CL2008002376A1/es unknown
- 2008-08-12 AU AU2008288429A patent/AU2008288429A1/en not_active Abandoned
- 2008-08-12 EP EP08803003A patent/EP2195294A1/de not_active Withdrawn
- 2008-08-12 TW TW097130726A patent/TW200916461A/zh unknown
- 2008-08-12 WO PCT/EP2008/060559 patent/WO2009021942A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010535837A (ja) | 2010-11-25 |
| UY31283A1 (es) | 2009-03-31 |
| AU2008288429A1 (en) | 2009-02-19 |
| BRPI0815498A2 (pt) | 2015-02-10 |
| AR068806A1 (es) | 2009-12-09 |
| EP2195294A1 (de) | 2010-06-16 |
| WO2009021942A1 (de) | 2009-02-19 |
| KR20100053651A (ko) | 2010-05-20 |
| CA2696205A1 (en) | 2009-02-19 |
| US8222402B2 (en) | 2012-07-17 |
| US20110071286A1 (en) | 2011-03-24 |
| MX2010001600A (es) | 2010-03-15 |
| TW200916461A (en) | 2009-04-16 |
| DE102007038250A1 (de) | 2009-02-19 |
| CL2008002376A1 (es) | 2009-09-11 |
| CN101821237A (zh) | 2010-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |