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AR059248A1 - Heterociclos nitrogenados y sus usos como inhibidores de aterosclerosis. composiciones farmaceuticas - Google Patents

Heterociclos nitrogenados y sus usos como inhibidores de aterosclerosis. composiciones farmaceuticas

Info

Publication number
AR059248A1
AR059248A1 ARP070100394A ARP070100394A AR059248A1 AR 059248 A1 AR059248 A1 AR 059248A1 AR P070100394 A ARP070100394 A AR P070100394A AR P070100394 A ARP070100394 A AR P070100394A AR 059248 A1 AR059248 A1 AR 059248A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
group
substituted
heterocyclic
heterocyclic group
Prior art date
Application number
ARP070100394A
Other languages
English (en)
Inventor
Y Nakamura
N Hayashi
T Higashijima
H Kubota
K Oka
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of AR059248A1 publication Critical patent/AR059248A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Poseen una actividad inhibitoria contra la proteína de transferencia de colesteril éster {CETP).Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto caracterizado porque posee la formula general (1) en donde, Y es un grupo metileno opcionalmente sustituido por sustituyente(s) seleccionado(s) de un grupo alquilo y un grupo oxo, o un enlace simple; A es (i) un grupo seleccionado de un grupo alquinilo opcionalmente sustituido, un átomo halogeno, un grupo oxo, un grupo hidroxilo, un grupo ciano, nitro, carboxilo, sulfo, alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alcoxilo opcionalmente sustituido, cicloalcoxilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, carbamoilo opcionalmente sustituido, carbamimidoilo opcionalmente sustituido, alquilsulfanilo opcionalmente sustituido, alquilsulfinilo opcionalmente sustituido, alquilsulfonilo opcionalmente sustituido, amino opcionalmente sustituido, sulfamoilo opcionalmente sustituido, alcanoilo opcionalmente sustituido, un grupo homocíclico opcionalmente sustituido, un grupo oxilo sustituido por grupo homocíclico opcionalmente sustituido, un grupo carbonilo sustituido por el grupo homocíclico opcionalmente sustituido, un grupo heterocíclico opcionalmente sustituido, un grupo oxilo sustituido por grupo heterocíclico opcionalmente sustituido, y un grupo carbonilo sustituido por el grupo heterocíclico opcionalmente sustituido; (ji) un grupo homocíclico opcionalmente sustituido por 1 a 5 sustituyentes seleccionados independientemente de los grupos como los definidos precedentemente en (i); o (iii) un grupo heterocíclico opcionalmente sustituido por 1 a 5 sustituyentes seleccionados independientemente de grupos como los definidos precedentemente en (i); B es un grupo heterocíclico opcionalmente sustituido por 1 a 5 sustituyentes seleccionados independientemente de los grupos siguientes: un grupo alquinilo opcionalmente sustituido un átomo halogeno, un grupo oxo, hidroxilo, ciano, nitro, carboxilo, sulfo, alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alcoxilo opcionalmente sustituido, cicloalcoxilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, carbamoilo opcionalmente sustituido, carbamimidoilo opcionalmente sustituido, alquilsulfanilo opcionalmente sustituido, alquilsulfinilo opcionalmente sustituido, alquilsulfonilo opcionalmente sustituido, un grupo amino opcionalmente sustituido, un sulfamoilo opcionalmente sustituido; un alcanoilo opcionalmente sustituido, un grupo homocíclico opcionalmente sustituido, un grupo oxilo sustituido por el grupo homocíclico opcionalmente sustituido, un grupo carbonilo sustituido por grupo homocíclico opcionalmente sustituido, un grupo heterocíclico opcionalmente sustituido, un grupo oxilo sustituido por el grupo heterocíclico opcionalmente sustituido, un grupo carbonilo sustituido por el grupo heterocíclico opcionalmente sustituido, y un grupo alquileno; en donde dicho grupo alquileno puede tener 1 a 3 heteroátomos seleccionados independientemente de átomos de oxígeno, azufre y nitrogeno y además opcionalmente puede tener sustituyente(s); R1 es un átomo de hidrogeno o un grupo alquilo opcionalmente sustituido; en donde el grupo alquilo además puede ser opcionalmente sustituido por sustituyente(s) seleccionado(s) de un grupo homocíclico opcionalmente sustituido y un grupo heterocíclico opcionalmente sustituido; R2 es un grupo seleccionado de un grupo alquinilo opcionalmente sustituido, un átomo halogeno, un grupo oxo, hidroxilo, ciano, nitro, carboxilo, sulfo, un grupo alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alcoxilo opcionalmente sustituido, cicloalcoxilo opcionalmente; alcoxicarbonilo opcionalmente sustituido, carbamoilo opcionalmente sustituido, carbamidoilo opcionalmente sustituido, alquilsulfanilo opcionalmente sustituido, alquilsulfinilo opcionalmente sustituido, alquilsulfonilo opcionalmente sustituido, amino opcionalmente sustituido, sulfamoilo opcionalmente sustituido, alcanoilo opcionalmente sustituido, un grupo homocíclico opcionalmente sustituido, un grupo oxo sustituido por grupo homocíclico opcionalmente sustituido, un grupo carbonilo sustituido por el grupo homocíclico opcionalmente sustituido, un grupo heterocíclico opcionalmente sustituido, un grupo oxo sustituido por el grupo heterocíclico opcionalmente sustituido, y un grupo carbonilo sustituido por grupo heterocíclico opcionalmente sustituido, o un derivado farmacéuticamente aceptable del mismo.
ARP070100394A 2006-01-31 2007-01-30 Heterociclos nitrogenados y sus usos como inhibidores de aterosclerosis. composiciones farmaceuticas AR059248A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006023571 2006-01-31
JP2006322854 2006-11-30

Publications (1)

Publication Number Publication Date
AR059248A1 true AR059248A1 (es) 2008-03-19

Family

ID=37951932

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070100394A AR059248A1 (es) 2006-01-31 2007-01-30 Heterociclos nitrogenados y sus usos como inhibidores de aterosclerosis. composiciones farmaceuticas

Country Status (9)

Country Link
US (1) US20090023729A1 (es)
EP (1) EP1979341B1 (es)
JP (1) JP2009524579A (es)
AR (1) AR059248A1 (es)
AT (1) ATE552254T1 (es)
PE (1) PE20071025A1 (es)
TW (1) TW200804342A (es)
UY (1) UY30118A1 (es)
WO (1) WO2007088999A1 (es)

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