PE20090891A1 - Profarmacos dipeptoides como agonistas de los receptores de adenosina a1 - Google Patents
Profarmacos dipeptoides como agonistas de los receptores de adenosina a1Info
- Publication number
- PE20090891A1 PE20090891A1 PE2008001244A PE2008001244A PE20090891A1 PE 20090891 A1 PE20090891 A1 PE 20090891A1 PE 2008001244 A PE2008001244 A PE 2008001244A PE 2008001244 A PE2008001244 A PE 2008001244A PE 20090891 A1 PE20090891 A1 PE 20090891A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- amino
- thiazol
- chlorophenyl
- thio
- Prior art date
Links
- 108010060263 Adenosine A1 Receptor Proteins 0.000 title abstract 2
- 102000030814 Adenosine A1 receptor Human genes 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 8
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 3
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 2
- -1 CARBOXYL Chemical group 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- UHPIOPMELXIDLL-UHFFFAOYSA-N pyridine-3,5-dicarbonitrile Chemical compound N#CC1=CN=CC(C#N)=C1 UHPIOPMELXIDLL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
Abstract
REFERIDO A COMPUESTOS PROFARMACOS DERIVADOS DE 2-AMINO-6-({[2-(4-CLOROFENIL)-1,3-TIAZOL-4-IL]METIL}TIO)-4-[4-(2-HIDROXIETOXI)FENIL]PIRIDIN-3,5-DICARBONITRILO DE FORMULA (I): DONDE RA ESTA REPRESENTADO POR (*), L1 Y L2 SON CADA UNO UN ENLACE O -CH2-; R1, R2 Y R3 SON CADA UNO H O METILO; R4 Y R6 SON CADA UNO H O LOS GRUPOS LATERALES DE UN ALFA-AMINOACIDO NATURAL; R5 Y R7 SON CADA UNO H O METILO; L3 ES ALCANO(C2-C4)-DIILO SUSTITUIDO CON AMINO; R8, R9 Y R10 SON H O METILO; m ES 2, 3, 4, 5 O 6; L4 ES ALCANO(C2-C4-DIILO), SUSTITUIDO CON CARBOXILO; R11 ES H O METILO; n ES 1, 2, 3 O 4. SON COMPUESTOS PREFERIDOS DICLORHIDRATO DE L-LISIL-L-VALINATO DE 2-{4-[2-AMINO-6-({[2-(4-CLOROFENIL)-1,3-TIAZOL-4-IL]METIL}TIO)-3,5-DICIANOPIRIDIN-4-IL]FENOXI}ETILO; CLORHIDRATO DE B-ALANIL-L-VALINATO DE 2-{4-[2-AMINO-6-({[2-(4-CLOROFENIL)-1,3-TIAZOL-4-IL]METIL}TIO)-3,5-DICIANOPIRIDIN-4-IL]FENOXI}ETILO; DICLORHIDRATO DE L-ARGINIL-L-VALINATO DE 2-{4-[2-AMINO-6-({[2-(4-CLOROFENIL)-1,3-TIAZOL-4-IL]METIL}TIO)-3,5-DICIANOPIRIDIN-4-IL]FENOXI}ETILO; ENTRE OTROS. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE ADENOSINA A1, SIENDO UTILES PARA LA PREVENCION Y TERAPIA DE ENFERMEDADES, CARDIOVASCULARES, UROGENITALES, RESPIRATORIAS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007036076A DE102007036076A1 (de) | 2007-08-01 | 2007-08-01 | Dipeptoid-Produgs und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090891A1 true PE20090891A1 (es) | 2009-08-08 |
Family
ID=40010616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001244A PE20090891A1 (es) | 2007-08-01 | 2008-07-22 | Profarmacos dipeptoides como agonistas de los receptores de adenosina a1 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8703696B2 (es) |
| EP (1) | EP2185552B1 (es) |
| JP (1) | JP5486492B2 (es) |
| KR (1) | KR101550077B1 (es) |
| CN (1) | CN101821263B (es) |
| AR (1) | AR067779A1 (es) |
| AU (1) | AU2008280983B2 (es) |
| BR (1) | BRPI0814963A2 (es) |
| CA (1) | CA2695036C (es) |
| CL (1) | CL2008002142A1 (es) |
| CY (1) | CY1115114T1 (es) |
| DE (1) | DE102007036076A1 (es) |
| DK (1) | DK2185552T3 (es) |
| ES (1) | ES2459441T3 (es) |
| HR (1) | HRP20140470T1 (es) |
| IL (1) | IL202892A (es) |
| JO (1) | JO2941B1 (es) |
| PE (1) | PE20090891A1 (es) |
| PL (1) | PL2185552T3 (es) |
| PT (1) | PT2185552E (es) |
| RU (2) | RU2486183C9 (es) |
| SI (1) | SI2185552T1 (es) |
| TW (1) | TWI436766B (es) |
| UY (1) | UY31244A1 (es) |
| WO (1) | WO2009015811A1 (es) |
| ZA (1) | ZA201000707B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004042607A1 (de) | 2004-09-03 | 2006-03-09 | Bayer Healthcare Ag | Substituierte Phenylaminothiazole und ihre Verwendung |
| DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) * | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102007061764A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
| DE102007061763A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
| DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| ES2428818T3 (es) * | 2008-05-29 | 2013-11-11 | Bayer Intellectual Property Gmbh | Dicianopiridinas sustituidas con 2-alcoxi y su uso |
| DE102008062567A1 (de) * | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) * | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| SMT202500474T1 (it) | 2010-12-03 | 2026-01-12 | Nalpropion Pharmaceuticals Llc | Aumento della biodisponibilità farmacologica nella terapia con naltrexone |
| MA39101A1 (fr) * | 2013-12-12 | 2017-08-31 | Bayer Pharma AG | Agonistes a1 de l'adénosine utilisés comme médicaments contre les maladies des reins |
| JP6855243B2 (ja) | 2014-01-24 | 2021-04-07 | エイアイ・セラピューティクス・インコーポレーテッド | 癌治療のためのアピリモド（ａｐｉｌｉｍｏｄ）組成物 |
| EP3581184B1 (en) * | 2014-11-07 | 2021-02-24 | AI Therapeutics, Inc. | Apilimod for use in the treatment of renal cancer |
| WO2017137528A1 (en) | 2016-02-12 | 2017-08-17 | Charité - Universitätsmedizin Berlin | Adenosine a1 receptor agonist for use in treatment of status epilepticus |
| WO2018153897A1 (de) * | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern |
| WO2018153895A1 (de) * | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten |
| WO2018153899A1 (de) * | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc) |
| WO2018153900A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern |
| WO2018153898A1 (de) * | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten |
| CN117122743A (zh) * | 2023-08-10 | 2023-11-28 | 南京圣德医疗科技有限公司 | 一种人工心脏生物瓣膜的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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2007
- 2007-08-01 DE DE102007036076A patent/DE102007036076A1/de not_active Withdrawn
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2008
- 2008-07-21 CL CL2008002142A patent/CL2008002142A1/es unknown
- 2008-07-22 PE PE2008001244A patent/PE20090891A1/es not_active Application Discontinuation
- 2008-07-22 UY UY31244A patent/UY31244A1/es not_active Application Discontinuation
- 2008-07-23 ES ES08784986.5T patent/ES2459441T3/es active Active
- 2008-07-23 HR HRP20140470AT patent/HRP20140470T1/hr unknown
- 2008-07-23 BR BRPI0814963-1A2A patent/BRPI0814963A2/pt not_active IP Right Cessation
- 2008-07-23 DK DK08784986.5T patent/DK2185552T3/da active
- 2008-07-23 CN CN200880101445.1A patent/CN101821263B/zh not_active Expired - Fee Related
- 2008-07-23 PL PL08784986T patent/PL2185552T3/pl unknown
- 2008-07-23 WO PCT/EP2008/006027 patent/WO2009015811A1/de not_active Ceased
- 2008-07-23 AU AU2008280983A patent/AU2008280983B2/en not_active Ceased
- 2008-07-23 EP EP08784986.5A patent/EP2185552B1/de not_active Not-in-force
- 2008-07-23 RU RU2010106877/04A patent/RU2486183C9/ru not_active IP Right Cessation
- 2008-07-23 US US12/671,694 patent/US8703696B2/en not_active Expired - Fee Related
- 2008-07-23 PT PT87849865T patent/PT2185552E/pt unknown
- 2008-07-23 CA CA2695036A patent/CA2695036C/en not_active Expired - Fee Related
- 2008-07-23 KR KR1020107002102A patent/KR101550077B1/ko not_active Expired - Fee Related
- 2008-07-23 SI SI200831218T patent/SI2185552T1/sl unknown
- 2008-07-23 JP JP2010518541A patent/JP5486492B2/ja not_active Expired - Fee Related
- 2008-07-29 JO JO2008339A patent/JO2941B1/en active
- 2008-07-31 TW TW097128917A patent/TWI436766B/zh not_active IP Right Cessation
- 2008-08-01 AR ARP080103358A patent/AR067779A1/es unknown
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- 2009-12-22 IL IL202892A patent/IL202892A/en not_active IP Right Cessation
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