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PE20090839A1 - Derivados de isoxazol-imidazol - Google Patents

Derivados de isoxazol-imidazol

Info

Publication number
PE20090839A1
PE20090839A1 PE2008001060A PE2008001060A PE20090839A1 PE 20090839 A1 PE20090839 A1 PE 20090839A1 PE 2008001060 A PE2008001060 A PE 2008001060A PE 2008001060 A PE2008001060 A PE 2008001060A PE 20090839 A1 PE20090839 A1 PE 20090839A1
Authority
PE
Peru
Prior art keywords
phenyl
isoxazole
trifluoromethyl
isoxazol
imidazol
Prior art date
Application number
PE2008001060A
Other languages
English (en)
Inventor
Bernd Buettelmann
Roland Jakob-Roetne
Henner Knust
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735035&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090839(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090839A1 publication Critical patent/PE20090839A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDO A DERIVADOS DE ISOXAZOL-IMIDAZOL DE FORMULA (I), DONDE R1 Y R2 SON CADA UNO H, HALOGENO, HALOALCOXI C1-C7; R3 ES FENILO, HETEROARILO DE 6 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-FENIL-4-(1-FENIL-1H-IMIDAZOL-4-IL)-5-TRIFLUOROMETIL-ISOXAZOL; 4-[1-(4-FLUORO-FENIL)-1H-MIDAZOL-4-IL]-3-FENIL-5-TRIFLUOROMETIL-ISOXAZOL; 1-{4-[4-(3-FENIL-5-TRIFLUOROMETIL-ISOXAZOL-4-IL)-IMIDAZOL-1-IL]-FENIL}-ETANONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHO COMPUESTO TIENE ACTIVIDAD Y SELECTIVIDAD PARA EL SITIO DE UNION DEL RECEPTOR GABA A ALFA5 SIENDO UTIL EN EL TRATAMIENTO DE TRANSTORNOS COGNITIVOS TAL COMO LA ENFERMEDAD DE ALZHEIMER
PE2008001060A 2007-06-22 2008-06-20 Derivados de isoxazol-imidazol PE20090839A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07110846 2007-06-22

Publications (1)

Publication Number Publication Date
PE20090839A1 true PE20090839A1 (es) 2009-07-02

Family

ID=39735035

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001060A PE20090839A1 (es) 2007-06-22 2008-06-20 Derivados de isoxazol-imidazol

Country Status (17)

Country Link
US (1) US7851469B2 (es)
EP (1) EP2170873B1 (es)
JP (1) JP5416103B2 (es)
KR (1) KR101228194B1 (es)
CN (1) CN101965344B (es)
AR (1) AR067075A1 (es)
AT (1) ATE519760T1 (es)
AU (1) AU2008267894B2 (es)
BR (1) BRPI0814718A2 (es)
CA (1) CA2690975A1 (es)
CL (1) CL2008001820A1 (es)
ES (1) ES2369805T3 (es)
IL (1) IL202667A0 (es)
MX (1) MX2009014001A (es)
PE (1) PE20090839A1 (es)
TW (1) TW200911795A (es)
WO (1) WO2009000662A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013001265A2 (pt) 2010-07-19 2016-05-17 Syngenta Participations Ag microbicidas
EP2595985A1 (en) 2010-07-19 2013-05-29 Syngenta Participations AG Isoxazole, isothiazole, furane and thiophene compounds as microbicides
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CA2876778A1 (en) 2012-06-26 2014-01-03 Saniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
AU2013283488A1 (en) 2012-06-26 2015-01-15 Saniona Aps A phenyl triazole derivative and its use for modulating the GABAA receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
EP3619207B1 (en) 2017-05-04 2021-06-23 Basf Se Substituted 5-(haloalkyl)-5-hydroxy-isoxazolines for combating phytopathogenic fungi
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525205A1 (de) 1984-09-11 1986-03-20 Hoechst Ag, 6230 Frankfurt Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols
GB9808663D0 (en) 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic agents
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
US6511987B1 (en) 1999-11-12 2003-01-28 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
EP1411942A4 (en) 2001-07-05 2005-01-26 Synaptic Pharma Corp SUBSTITUTED ANILINPIPERIDINES AS MCH-SELECTIVE ANTAGONISTS
ES2299618T3 (es) 2001-11-20 2008-06-01 Eli Lilly And Company Agonistas beta-3-adrenergicos.
GB0128160D0 (en) 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
WO2004022555A1 (en) 2002-09-06 2004-03-18 Vertex Pharmaceuticals Incorporated Isoxazoles and their use in the treatment of ischemic diseases
ES2770035T3 (es) * 2003-04-11 2020-06-30 Ptc Therapeutics Inc Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
WO2005118568A1 (en) 2004-06-01 2005-12-15 F. Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
GB0318447D0 (en) 2003-08-05 2003-09-10 Merck Sharp & Dohme Therapeutic agents
EP1773807A2 (en) 2004-06-14 2007-04-18 Takeda San Diego, Inc. Kinase inhibitors
EP1812427A4 (en) 2004-10-15 2009-10-14 Scripps Research Inst FATTY ACID AMIDE HYDROLASE OXADIAZOLE KETONE INHIBITORS
US20070060589A1 (en) 2004-12-21 2007-03-15 Purandare Ashok V Inhibitors of protein arginine methyl transferases
KR101181692B1 (ko) * 2004-12-28 2012-09-19 아스카 세이야쿠 가부시키가이샤 피리미디닐이속사졸 유도체
KR101121372B1 (ko) * 2005-12-27 2012-04-12 에프. 호프만-라 로슈 아게 아릴-이속사졸-4-일-이미다졸 유도체
BRPI0620760A2 (pt) * 2005-12-27 2011-11-22 Hoffmann La Roche derivados de aril-isoxazol-4-il-imidazo[1,5]piridina
BRPI0706560A2 (pt) * 2006-01-17 2011-03-29 Hoffmann La Roche derivados de aril-isoxazol-4-il-imidazo [1,2-a] piridina úteis para o tratamento de doença de alzheimer por intermédio de receptores gaba

Also Published As

Publication number Publication date
CN101965344B (zh) 2013-03-06
MX2009014001A (es) 2010-01-28
IL202667A0 (en) 2010-06-30
KR20100023042A (ko) 2010-03-03
AU2008267894B2 (en) 2012-08-23
CL2008001820A1 (es) 2009-05-29
EP2170873A1 (en) 2010-04-07
JP5416103B2 (ja) 2014-02-12
CA2690975A1 (en) 2008-12-31
AR067075A1 (es) 2009-09-30
JP2010530862A (ja) 2010-09-16
KR101228194B1 (ko) 2013-01-30
ES2369805T3 (es) 2011-12-07
WO2009000662A1 (en) 2008-12-31
US20090005370A1 (en) 2009-01-01
EP2170873B1 (en) 2011-08-10
ATE519760T1 (de) 2011-08-15
TW200911795A (en) 2009-03-16
BRPI0814718A2 (pt) 2015-02-24
US7851469B2 (en) 2010-12-14
AU2008267894A1 (en) 2008-12-31
CN101965344A (zh) 2011-02-02

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