PE20080695A1 - Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel - Google Patents
Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weelInfo
- Publication number
- PE20080695A1 PE20080695A1 PE2007000511A PE2007000511A PE20080695A1 PE 20080695 A1 PE20080695 A1 PE 20080695A1 PE 2007000511 A PE2007000511 A PE 2007000511A PE 2007000511 A PE2007000511 A PE 2007000511A PE 20080695 A1 PE20080695 A1 PE 20080695A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- dihydropirazolopyrimidinone
- derivatives
- inhibitors
- alyl
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000020233 phosphotransferase Human genes 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical class CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DIHIDROPIRAZOLOPIRIMIDINONA DE FORMULA (I), EN DONDE A ES DE FORMULA (aa1); R1C ES H, ALQUENILO INFERIOR O Q3-A3(R1d)R1e; DONDE A3 ES N; METINO O 1-VINIL-2-ILDENO; Q3 ES UN ENLACE O ALQUILENO INFERIOR; R1d Y R1e SON INDEPENDIENTEMENTE H, HALOGENO, CN, HIDROXILO, ENTRE OTROS; R1 ES ALQUENILO O ALQUINILO INFERIOR; R2 ES FENILO, PIRIDILO O TIENILO EL CUAL PUEDE TENER UN GRUPO A4(R1g)R1h; R5 y R6 SON H, ALQUILO INFERIOR O HIDROXIALQUILO INFERIOR. SON SELECCIONADOS: 3-(2-ALIL-6-{[4-(4-METILPIPERAZIN -1-IL)FENIL]AMINO}-3-OXO-1,2-DIHIDRO-3H-PIRAZOLO[3,4-d]PIRIMIDIN-1-IL)-N,N-DIMETILBENZAMIDA, 2-ALIL-1-[3-(1-HIDROXI-1-METILETIL)FENIL]-6-{[4-(4-METILPIPERAZIN-1-IL)FENIL]AMINO}-1,2-DIHIDRO-3H-PIRAZOLO[3,4-d]PIRIMIDIN-3-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA WEEL Y SON UTILES EN EL TRATAMIENTO DE DIVERSOS CANCERES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006124208 | 2006-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080695A1 true PE20080695A1 (es) | 2008-06-28 |
Family
ID=38655640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000511A PE20080695A1 (es) | 2006-04-27 | 2007-04-24 | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
Country Status (38)
| Country | Link |
|---|---|
| US (4) | US7935708B2 (es) |
| EP (2) | EP2017278B1 (es) |
| JP (2) | JP4513919B2 (es) |
| KR (1) | KR101409161B1 (es) |
| CN (1) | CN101432284B (es) |
| AR (1) | AR060635A1 (es) |
| AT (1) | ATE475662T1 (es) |
| AU (1) | AU2007244185B2 (es) |
| BR (1) | BRPI0710081A2 (es) |
| CA (1) | CA2650119C (es) |
| CR (1) | CR10359A (es) |
| CY (2) | CY1111069T1 (es) |
| DE (1) | DE602007008085D1 (es) |
| DK (2) | DK2016080T3 (es) |
| DO (1) | DOP2007000084A (es) |
| EC (1) | ECSP088812A (es) |
| ES (2) | ES2348751T3 (es) |
| GT (1) | GT200800211A (es) |
| HN (1) | HN2008001532A (es) |
| HR (2) | HRP20161763T1 (es) |
| HU (1) | HUE032987T2 (es) |
| IL (1) | IL194367A (es) |
| LT (1) | LT2017278T (es) |
| MA (1) | MA30428B1 (es) |
| MX (1) | MX2008013063A (es) |
| MY (1) | MY145408A (es) |
| NO (1) | NO341617B1 (es) |
| NZ (1) | NZ571196A (es) |
| PE (1) | PE20080695A1 (es) |
| PL (2) | PL2016080T3 (es) |
| PT (2) | PT2017278T (es) |
| RU (1) | RU2437885C2 (es) |
| SI (2) | SI2016080T1 (es) |
| SV (1) | SV2009003060A (es) |
| TW (1) | TWI409262B (es) |
| UA (1) | UA96152C2 (es) |
| WO (2) | WO2007126122A1 (es) |
| ZA (1) | ZA200807748B (es) |
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| US20120157342A1 (en) * | 2009-09-02 | 2012-06-21 | Shinji Mizuarai | Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor |
| US8703779B2 (en) | 2009-09-15 | 2014-04-22 | Merck Sharp & Dohme Corp. | Preparation of crystalline forms of dihydropyrazolopyrimidinone |
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| CN116836184B (zh) * | 2022-03-25 | 2025-07-25 | 药雅科技(上海)有限公司 | Wee1激酶抑制剂的制备及其应用 |
| CN117402162A (zh) | 2022-07-13 | 2024-01-16 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
| CN115073460B (zh) * | 2022-07-13 | 2023-07-25 | 苏州施安鼎泰生物医药技术有限公司 | 一种嘧啶并[5,4-c][2,6]萘啶衍生物及其制备方法以及药物组合物和应用 |
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| TW202519226A (zh) | 2023-11-08 | 2025-05-16 | 美商艾克塞里克斯公司 | 使用抑制ｐｋｍｙｔ１之化合物治療癌症之方法 |
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