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PE20090704A1 - Derivados heterociclicos triciclicos - Google Patents

Derivados heterociclicos triciclicos

Info

Publication number
PE20090704A1
PE20090704A1 PE2008001616A PE2008001616A PE20090704A1 PE 20090704 A1 PE20090704 A1 PE 20090704A1 PE 2008001616 A PE2008001616 A PE 2008001616A PE 2008001616 A PE2008001616 A PE 2008001616A PE 20090704 A1 PE20090704 A1 PE 20090704A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
tricycle
hexahydroisocromene
pirrol
Prior art date
Application number
PE2008001616A
Other languages
English (en)
Inventor
Simon James Anthony Grove
Takao Kiyoi
Ashvinkumar Dhirubhai Mistry
Peter Christopher Ray
Grant Wishart
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20090704A1 publication Critical patent/PE20090704A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE HETEROCICLICOS TRICICLICOS DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6), ALQUENILO(C2-C6), ALQUINILO(C2-C6), ENTRE OTROS; R2 ES H, CICLOALQUILO(C3-C7), ALQUILO C1.C6, CICLOALQUILO(C3-C7)-ALQUILO(C1-C2), ENTRE OTROS; R3 ES H, ALQUILO(C1-C6), ALCOXI(C1-C4)-ALQUILO(C1-C2),ENTE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS; X ES O, S, SO, SO2, ENTRE OTROS; Y1 ES N, CR6; Y2 ES N, CR7; Y3 ES N, CR8; Y4 ES N, CR9, DONDE NO MAS DE UNO DE Y1-Y4 PUEDE SER SIMULTANEAMENTE N; R6, R7 Y R8 SON CADA UNO H, ALQUENILO(C2-C6), ALQUILOXI(C1-C6), ENTRE OTROS; R9 ES H, HALO, CN, ALQUILOXI(C1-C6), ENTRE OTROS; m ES DE 1-2; n ES DE 0-1. SON COMPUESTOS PREFERIDOS: CIS-6-CLORO-1,2,3a,5,9b-HEXAHIDROISOCROMENO[3,4-c]PIRROL; CIS-6-(TRIFLUOROMETIL)-1,2,3,3a,5,9b-HEXAHIDROISOCROMENO[3,4-c]PIRROL; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MODULADORES DEL RECEPTOR 5-HT2, UTILES EN EL TRATAMIENTO DE LA OBESIDAD, ESQUIZOFRENIA Y DISFUNCION COGNITIVA
PE2008001616A 2007-09-17 2008-09-16 Derivados heterociclicos triciclicos PE20090704A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07116561 2007-09-17

Publications (1)

Publication Number Publication Date
PE20090704A1 true PE20090704A1 (es) 2009-06-20

Family

ID=39718515

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001616A PE20090704A1 (es) 2007-09-17 2008-09-16 Derivados heterociclicos triciclicos

Country Status (17)

Country Link
US (1) US20100210680A1 (es)
EP (1) EP2203454A1 (es)
JP (1) JP5447380B2 (es)
KR (1) KR20100072027A (es)
CN (1) CN101801980B (es)
AR (1) AR068521A1 (es)
AU (1) AU2008300607B2 (es)
BR (1) BRPI0816992A2 (es)
CA (1) CA2698436A1 (es)
CL (1) CL2008002767A1 (es)
CO (1) CO6260138A2 (es)
MX (1) MX2010002900A (es)
NZ (1) NZ583627A (es)
PE (1) PE20090704A1 (es)
RU (1) RU2010115337A (es)
TW (1) TW200924752A (es)
WO (1) WO2009037220A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
EP2432783B1 (en) * 2009-05-22 2013-05-01 Abbott Laboratories Modulators of 5-ht receptors and methods of use thereof
RU2015140748A (ru) * 2010-05-21 2018-12-26 Эббви Инк. Модуляторы 5-нт рецепторов и способы их применения
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US20120309796A1 (en) 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2019170543A1 (en) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
KR20250132455A (ko) 2022-10-25 2025-09-04 아르투스 테라퓨틱스 인코포레이티드 상피 및/또는 내피 장벽 기능을 강화하기 위한 치료제
CN116253627B (zh) * 2022-12-27 2025-09-05 大连双硼医药化工有限公司 一种合成2-溴-6-羟基苯甲醛的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132710A (en) 1976-12-20 1979-01-02 Ayerst, Mckenna And Harrison, Ltd. [2]Benzopyrano[3,4-c]pyridines and process therefor
US4132709A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna & Harrison, Ltd. [2]Benzopyrano[4,3-c]pyridine derivatives and process therefor
NL8005754A (nl) * 1980-10-18 1982-05-17 Akzo Nv Benzo 4,5 pyrano 2,3-c pyrrool derivaten.
US4666916A (en) * 1985-11-08 1987-05-19 Ciba-Geigy Corporation Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
ES2090119T3 (es) * 1988-12-15 1996-10-16 Abbott Lab Agentes selectivos de 5-ht.
GB8917333D0 (en) * 1989-07-28 1989-09-13 Merck Sharp & Dohme Therapeutic agents
WO1993008166A1 (en) * 1991-10-24 1993-04-29 The Upjohn Company Benzo-isoquinoline derivatives and analogs and their use in therapeutics
FR2722194B1 (fr) 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent

Also Published As

Publication number Publication date
WO2009037220A1 (en) 2009-03-26
BRPI0816992A2 (pt) 2015-03-24
AR068521A1 (es) 2009-11-18
US20100210680A1 (en) 2010-08-19
CN101801980B (zh) 2014-03-12
NZ583627A (en) 2011-08-26
CA2698436A1 (en) 2009-03-26
AU2008300607A1 (en) 2009-03-26
CL2008002767A1 (es) 2009-03-06
EP2203454A1 (en) 2010-07-07
CN101801980A (zh) 2010-08-11
AU2008300607B2 (en) 2013-08-22
JP2010539139A (ja) 2010-12-16
CO6260138A2 (es) 2011-03-22
JP5447380B2 (ja) 2014-03-19
KR20100072027A (ko) 2010-06-29
MX2010002900A (es) 2010-03-31
TW200924752A (en) 2009-06-16
RU2010115337A (ru) 2011-10-27

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