[go: up one dir, main page]

PE20070793A1 - Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos - Google Patents

Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos

Info

Publication number
PE20070793A1
PE20070793A1 PE2006001266A PE2006001266A PE20070793A1 PE 20070793 A1 PE20070793 A1 PE 20070793A1 PE 2006001266 A PE2006001266 A PE 2006001266A PE 2006001266 A PE2006001266 A PE 2006001266A PE 20070793 A1 PE20070793 A1 PE 20070793A1
Authority
PE
Peru
Prior art keywords
dihydro
quinolin
ona
compounds containing
containing nitrogen
Prior art date
Application number
PE2006001266A
Other languages
English (en)
Inventor
Nathalie Cailleau
David Thomas Davies
Joel Michael Esken
Alan Joseph Hennessy
Sukumar Senthil Kumar Kusalakumari
Roger Edward Markwell
Timothy James Miles
Neil David Pearson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070793A1 publication Critical patent/PE20070793A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS 1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA SUSTITUIDOS DE FORMULA (I), EN DONDE R1a Y R1b SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, ALQUILO(C1-C6), TRIFLUOROMETILO, ENTRE OTROS; R2 ES H O ALQUIL(C1-C4); A ES UN GRUPO ia), ib) O ii); U ES CO Y CH2; R5 ES UN SISTEMA DE ANILLO BICICLICO, CARBOCICLICO O HETEROCICLICO DE FORMULA B) OPCIONALMENTE SUSTITUIDO; R9 MES H O HIDROXI. SON PREFERIDOS 1-({4-[(2,3-DIHIDRO-[1,4]DIOXINO[2,3-c]PIRIDIN-7-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-9-FLUORO-1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA, 9-FLUORO-1-({(3R,4S)-3-HIDROXI-4-[([1,3]OXATIOLO[5,4-c]PIRIDIN-6-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD ANTIBACTERIANA Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS ORIGINADAS POR ORGANISMOS GRAM NEGATIVOS COMO GRAM PROSITIVOS
PE2006001266A 2005-10-21 2006-10-19 Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos PE20070793A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72897505P 2005-10-21 2005-10-21
US82659006P 2006-09-22 2006-09-22

Publications (1)

Publication Number Publication Date
PE20070793A1 true PE20070793A1 (es) 2007-08-23

Family

ID=38256822

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001266A PE20070793A1 (es) 2005-10-21 2006-10-19 Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos

Country Status (26)

Country Link
US (2) US20080221110A1 (es)
EP (1) EP1954697B1 (es)
JP (1) JP2009512695A (es)
KR (1) KR20080064173A (es)
AR (1) AR057981A1 (es)
AT (1) ATE458737T1 (es)
AU (1) AU2006335042A1 (es)
BR (1) BRPI0617467A2 (es)
CA (1) CA2626641A1 (es)
CR (1) CR9930A (es)
CY (1) CY1110137T1 (es)
DE (1) DE602006012535D1 (es)
DK (1) DK1954697T3 (es)
EA (1) EA200801128A1 (es)
ES (1) ES2340531T3 (es)
HR (1) HRP20100194T8 (es)
IL (1) IL190803A0 (es)
MA (1) MA29873B1 (es)
NO (1) NO20082191L (es)
NZ (1) NZ567315A (es)
PE (1) PE20070793A1 (es)
PL (1) PL1954697T3 (es)
PT (1) PT1954697E (es)
SI (1) SI1954697T1 (es)
TW (1) TW200736263A (es)
WO (1) WO2007081597A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006335042A1 (en) * 2005-10-21 2007-07-19 Glaxo Group Limited Compounds
DE602006013878D1 (de) 2005-12-22 2010-06-02 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
WO2007115947A1 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0608263D0 (en) 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
GB0613208D0 (en) * 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
GB0705672D0 (en) * 2007-03-23 2007-05-02 Glaxo Group Ltd Compounds
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
GB0707706D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
HRP20100574T1 (hr) * 2007-04-20 2010-12-31 Glaxo Group Limited Tricklički spojevi s dušikom kao antibakterijska sredstva
EP2005995A1 (en) * 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
JP2011518149A (ja) 2008-04-15 2011-06-23 アクテリオン ファーマシューティカルズ リミテッド 三環式抗菌剤
AU2009278791A1 (en) 2008-08-04 2010-02-11 Actelion Pharmaceuticals Ltd Tricyclic alkylaminomethyloxazolidinone derivatives
CN104151315B (zh) * 2008-10-07 2017-01-11 埃科特莱茵药品有限公司 三环噁唑烷酮抗生素化合物
JP2012505866A (ja) * 2008-10-17 2012-03-08 グラクソ グループ リミテッド 抗菌剤として使用される三環式窒素化合物
SG172088A1 (en) 2008-12-12 2011-07-28 Actelion Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
WO2013038374A1 (en) 2011-09-16 2013-03-21 Actelion Pharmaceuticals Ltd Process for manufacturing a synthetic intermediate
WO2013080156A1 (en) 2011-11-30 2013-06-06 Actelion Pharmaceuticals Ltd 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics
AU2015304847B2 (en) 2014-08-22 2018-10-25 Glaxosmithkline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection
JP6772364B2 (ja) 2017-02-28 2020-10-21 三井化学アグロ株式会社 植物病害防除組成物およびそれを施用する植物病害の防除方法
AU2018266847A1 (en) * 2017-05-10 2019-11-28 Albajuna Therapeutics, S.L. Fc-fusion protein derivatives with high dual HIV antiviral and immunomodulatory activity
WO2021111124A1 (en) 2019-12-02 2021-06-10 Storm Therapeutics Limited Polyheterocyclic compounds as mettl3 inhibitors
UA130303C2 (uk) 2019-12-06 2026-01-14 Вертекс Фармасьютикалз Інкорпорейтед Заміщені тетрагідрофурани як модулятори натрієвих каналів
MX2023014378A (es) 2021-06-04 2023-12-15 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofurano carboxamidas como moduladores de canales de sodio.

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3323868A (en) * 1961-12-14 1967-06-06 Laporte Chemical Manufacture of hydrogen peroxide
NL294427A (es) * 1962-06-23
GB1394373A (en) * 1972-05-17 1975-05-14 Pfizer Ltd Control of plant diseases
US4066706A (en) * 1975-04-21 1978-01-03 Halcon International, Inc. Preparation of ethylbenzene hydroperoxide
DE2805915C3 (de) * 1978-02-13 1981-11-05 Dynamit Nobel Ag, 5210 Troisdorf Reaktor zur Oxidation von Gemischen aus p-Xylol und p-Toluylsäuremethylester mit sauerstoffhaltigen Gasen in flüssiger Phase
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
DE2914218C2 (de) * 1978-04-12 1985-10-24 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo N-Acylderivate des Ampicillins und Amoxicillins, Verfahren zu deren Herstellung und pharmazeutische Zubereitungen, welche die Verbindungen enthalten
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
DE3365391D1 (en) * 1982-03-25 1986-09-25 Ciba Geigy Ag Process for the preparation of 1,2,5,6-tetrahydro-4h-pyrrolo(3,2,1-ij)-quinolin-4-one and 5-halo-1,2,3-(1,2,dihydropyrrolo)-4-quinolone intermediates
US4595755A (en) * 1982-03-25 1986-06-17 Ciba-Geigy Corporation 5-halo-1,2,3-(1,2-dihydropyrrolo)-4-quinolones
US4443447A (en) * 1982-10-25 1984-04-17 Riker Laboratories, Inc. Phenyl-substituted tricyclic antibacterial agents
US4603199A (en) * 1982-10-25 1986-07-29 Riker Laboratories, Inc. Phenyl-substituted tricyclic antibacterial agent intermediates
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
JPH11222407A (ja) * 1997-11-14 1999-08-17 Sankyo Co Ltd 新規殺菌剤
US6689765B2 (en) * 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6289745B1 (en) * 1999-05-04 2001-09-18 James Bowers High temperature insertion type flow element and mounting extension
US6391865B1 (en) * 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US7825121B2 (en) * 1999-05-04 2010-11-02 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
AR032920A1 (es) * 2001-03-01 2003-12-03 Smithkline Beecham Corp Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7109213B2 (en) * 2002-01-29 2006-09-19 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
PA8577501A1 (es) * 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas
AR042486A1 (es) 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
JP2007522093A (ja) * 2003-09-22 2007-08-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ７−アミノアルキリデニル−複素環式キノロンおよびナフチリドン
US7691850B2 (en) * 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
JP2008505920A (ja) * 2004-07-08 2008-02-28 グラクソ　グループ　リミテッド 抗菌剤
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP1900732A4 (en) * 2005-06-24 2009-11-18 Toyama Chemical Co Ltd NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
AU2006335042A1 (en) * 2005-10-21 2007-07-19 Glaxo Group Limited Compounds
DE102005050892A1 (de) * 2005-10-21 2007-04-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
GB0521563D0 (en) * 2005-10-21 2005-11-30 Glaxo Group Ltd Novel compounds
DE602006013878D1 (de) * 2005-12-22 2010-06-02 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
WO2007115947A1 (en) * 2006-04-06 2007-10-18 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0608263D0 (en) * 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
KR101409261B1 (ko) * 2006-05-26 2014-06-18 다이쇼 세이야꾸 가부시끼가이샤 신규의 복소환 화합물 또는 그 염 및 그 중간체
GB0613208D0 (en) * 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) * 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
GB0705672D0 (en) * 2007-03-23 2007-05-02 Glaxo Group Ltd Compounds
EP1980251A1 (en) * 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
GB0707708D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
HRP20100574T1 (hr) * 2007-04-20 2010-12-31 Glaxo Group Limited Tricklički spojevi s dušikom kao antibakterijska sredstva
GB0707706D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
JP2009512695A (ja) 2009-03-26
DK1954697T3 (da) 2010-06-14
KR20080064173A (ko) 2008-07-08
HRP20100194T1 (hr) 2010-05-31
AU2006335042A1 (en) 2007-07-19
WO2007081597A2 (en) 2007-07-19
US20080280892A1 (en) 2008-11-13
NZ567315A (en) 2011-01-28
WO2007081597A3 (en) 2008-06-12
EP1954697B1 (en) 2010-02-24
PT1954697E (pt) 2010-05-17
EP1954697A2 (en) 2008-08-13
EA200801128A1 (ru) 2008-10-30
MA29873B1 (fr) 2008-10-03
HK1118546A1 (en) 2009-02-13
DE602006012535D1 (de) 2010-04-08
ATE458737T1 (de) 2010-03-15
CR9930A (es) 2008-07-29
BRPI0617467A2 (pt) 2011-07-26
SI1954697T1 (sl) 2010-05-31
ES2340531T3 (es) 2010-06-04
IL190803A0 (en) 2008-12-29
CY1110137T1 (el) 2015-01-14
NO20082191L (no) 2008-07-16
PL1954697T3 (pl) 2010-07-30
TW200736263A (en) 2007-10-01
AR057981A1 (es) 2008-01-09
HRP20100194T8 (hr) 2010-06-30
CA2626641A1 (en) 2007-07-19
US20080221110A1 (en) 2008-09-11

Similar Documents

Publication Publication Date Title
PE20070793A1 (es) Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos
PE20080182A1 (es) Derivados pirrolo-quinoxalinona como antibacterianos
PE20090648A1 (es) Compuestos para el tratamiento de la hepatitis c
AR046711A1 (es) 5-7-diaminopirazolo[4,3d]pirimidinas como inhibidores de la pde-5,composiciones farmaceuticas que las contienen y usos en el tratamiento de hipertensiones
AR066111A1 (es) Compuesto triciclico de imidazol, su uso para preparar un medicamento, composicion farmaceutica que lo comprende y compuestos intermediarios en la sintesis de dicho compuesto
PE20040265A1 (es) Compuestos de quinazolina utiles en terapia
PE20070367A1 (es) Compuestos de espiropiperidina como inhibidores de la enzima beta secretasa
PE20010544A1 (es) Derivados de mutilina utiles como agentes antibacterianos
AR011093A1 (es) Compuestos derivados de sulfonil urea, composicion farmaceutica que los contiene y procedimiento para su uso.
CO6220882A2 (es) Derivados de pirido-pirazina utiles como compuestos herbiicidas
PE20060531A1 (es) Derivados de piridazin-3-(2h)-ona como inhibidores de la fosfodiesterasa 4
PE20060691A1 (es) Serinamidas sustituidas por benzoilo
AR054809A1 (es) Compuestos de amino -5-heteroarilo (5 miembros) imidazolona y su uso para la modulacion de la b- secretasa
PE20091573A1 (es) Derivados heterociclicos de urea como inhibidores de adn girasa y/o topoisomerasa
PE20071064A1 (es) Derivados de pirrolonaftiridinonas como antibacterianos
PE20040450A1 (es) Heteroariloxi-aril-espiro-pirimidina-2,4,6-triona n-sustituida como inhibidores de metaloproteinasa
PE20011305A1 (es) Agentes diazabiciclicos activos en el snc
PE20060316A1 (es) Derivados de prolina como inhibidores de dipeptidil peptidasa-iv
GT200400092A (es) Preparacion y uso de derivados de alquilarilo para el tratamiento de la obesidad
AR030186A1 (es) Compuesto antibacteriano 3-aminoquinazolina-2,4-diona, composicion farmaceutica que lo comprende y su uso para fabricarla
PA8501801A1 (es) Inhibidores triciclicos de polimerasas (adp - polirribosas)
PE20060437A1 (es) COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
UY30051A1 (es) Derivados de pirimidina para el tratamiento del crecimiento celular anormal
PE20050141A1 (es) DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA COMO ANTAGONISTAS DEL RECEPTOR A2a ADENOSINA
PE20080277A1 (es) Derivados de azaindol espirociclicos y sustituidos

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed