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PE20090556A1 - DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO [1,2-b]-PIRIDAZINA COMO INHIBIDORES DE CASEINA QUINASAS Y SU PREPARACION - Google Patents

DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO [1,2-b]-PIRIDAZINA COMO INHIBIDORES DE CASEINA QUINASAS Y SU PREPARACION

Info

Publication number
PE20090556A1
PE20090556A1 PE2008001090A PE2008001090A PE20090556A1 PE 20090556 A1 PE20090556 A1 PE 20090556A1 PE 2008001090 A PE2008001090 A PE 2008001090A PE 2008001090 A PE2008001090 A PE 2008001090A PE 20090556 A1 PE20090556 A1 PE 20090556A1
Authority
PE
Peru
Prior art keywords
alkyl
optionally substituted
pyridin
casein kinase
pyridazine
Prior art date
Application number
PE2008001090A
Other languages
English (en)
Inventor
Garcia Antonio Almario
Philippe Burnier
Pascal George
Adrien Tak Li
Frederic Puech
Matthieu Barrague
Zhongli Gao
Roy Vaz
Qiuxia Zao
Cecile Enguehard
Alain Gueiffier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20090556A1 publication Critical patent/PE20090556A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

REFERIDA A UN DERIVADO DE PIRIDAZINA DE FORMULA (I), DONDE R2 ES ARILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R3 ES H, ALQUILO C1-C3, NR4R5, OH, ALCOXI C1-C4; A ES ALQUILENO C1-C7 OPCIONALMENTE SUSTITUIDO CON Ra; B ES ALQUILENO C1-C7 OPCIONALMENTE SUSTITUIDO CON Rb; L ES UN ATOMO DE NITROGENO OPCIONALMENTE SUSTITUIDO CON Rc O Rd O ES UN ATOMO DE CARBONO OPCIONALMENTE SUSTITUIDO CON Re1, Rd O Re2; DOS GRUPOS Ra PUEDEN FORMAR UN GRUPO ALQUILENO C1-C6; Ra Y Rb, Ra Y Rc O Rb Y Rc PUEDEN FORMAR CONJUNTAMENTE UN ENLACE O UN GRUPO ALQUILENO C1-C6; Rd ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; Re1 ES UN GRUPO -NR4R5 O UNA MONOAMINA CICLICA OPCIONALMENTE SUSTITUIDA CON F, OH, ALQUILO C1-C6, ALCOXI C1-C6; R4 Y R5 SON H, ALQUILO C1-C4, CICLOALQUILO C3-C7, CICLOALQUILO C3-C7-ALQUILO C1-C6; R7 Y R8 SON H O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: 2-FENIL-6-PIPERAZIN-1-IL-3-PIRIDIN-4-IL-IMIDAZO[1,2-b]PIRIDAZINA, 2-(4-FLUOROFENIL)-6-PIPERAZIN-1-IL-3-PIRIDIN-4-IL-IMIDAZO[1,2-b]PIRIDAZINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LA FOSFORILACION DE LA CASEINA POR LA CASEINA QUINASA 1 EPSILON CASEINA QUINASA 1 DELTA Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS DEL SUENO, TRANSTORNOS DEL HUMOR, DE ANSIEDAD, ENTRE OTROS
PE2008001090A 2007-06-28 2008-06-26 DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO [1,2-b]-PIRIDAZINA COMO INHIBIDORES DE CASEINA QUINASAS Y SU PREPARACION PE20090556A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94678507P 2007-06-28 2007-06-28
FR0704661A FR2918061B1 (fr) 2007-06-28 2007-06-28 Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
PE20090556A1 true PE20090556A1 (es) 2009-06-01

Family

ID=39203151

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001090A PE20090556A1 (es) 2007-06-28 2008-06-26 DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO [1,2-b]-PIRIDAZINA COMO INHIBIDORES DE CASEINA QUINASAS Y SU PREPARACION

Country Status (22)

Country Link
US (2) US8354405B2 (es)
EP (1) EP2170889B1 (es)
JP (1) JP5537424B2 (es)
KR (1) KR20100050492A (es)
CN (1) CN101765602A (es)
AR (1) AR069269A1 (es)
AU (1) AU2008281662A1 (es)
BR (1) BRPI0814807A2 (es)
CA (1) CA2691866A1 (es)
CL (1) CL2008001932A1 (es)
CO (1) CO6251269A2 (es)
EA (1) EA201070072A1 (es)
FR (1) FR2918061B1 (es)
MA (1) MA31572B1 (es)
MX (1) MX2009013948A (es)
NZ (1) NZ582677A (es)
PA (1) PA8786101A1 (es)
PE (1) PE20090556A1 (es)
TW (1) TW200911812A (es)
UY (1) UY31193A1 (es)
WO (1) WO2009016286A2 (es)
ZA (1) ZA200909186B (es)

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US10604523B2 (en) 2011-06-27 2020-03-31 Janssen Pharmaceutica Nv 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
WO2013023084A2 (en) 2011-08-09 2013-02-14 Fred Hutchinson Cancer Research Center Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells
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CN104540831B (zh) 2012-06-27 2017-11-07 4Sc探索有限责任公司 用于治疗癌症、自身免疫性炎症和cns紊乱的二氟二氧戊环‑氨基‑苯并咪唑激酶抑制剂
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Also Published As

Publication number Publication date
BRPI0814807A2 (pt) 2015-02-03
US8846676B2 (en) 2014-09-30
CA2691866A1 (fr) 2009-02-05
TW200911812A (en) 2009-03-16
CL2008001932A1 (es) 2009-09-25
EP2170889A2 (fr) 2010-04-07
US8354405B2 (en) 2013-01-15
EP2170889B1 (fr) 2016-08-17
PA8786101A1 (es) 2009-01-23
AR069269A1 (es) 2010-01-13
WO2009016286A3 (fr) 2009-04-09
UY31193A1 (es) 2009-01-30
NZ582677A (en) 2011-12-22
ZA200909186B (en) 2011-02-23
CN101765602A (zh) 2010-06-30
US20130012516A1 (en) 2013-01-10
AU2008281662A1 (en) 2009-02-05
KR20100050492A (ko) 2010-05-13
MA31572B1 (fr) 2010-08-02
FR2918061A1 (fr) 2009-01-02
JP2010531342A (ja) 2010-09-24
US20100179154A1 (en) 2010-07-15
FR2918061B1 (fr) 2010-10-22
CO6251269A2 (es) 2011-02-21
MX2009013948A (es) 2010-03-09
WO2009016286A2 (fr) 2009-02-05
JP5537424B2 (ja) 2014-07-02
EA201070072A1 (ru) 2010-08-30

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