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PE20081116A1 - Derivados de diaril, dipiridinil y arilpiridinil como antagonistas del receptor opioide - Google Patents

Derivados de diaril, dipiridinil y arilpiridinil como antagonistas del receptor opioide

Info

Publication number
PE20081116A1
PE20081116A1 PE2007001552A PE2007001552A PE20081116A1 PE 20081116 A1 PE20081116 A1 PE 20081116A1 PE 2007001552 A PE2007001552 A PE 2007001552A PE 2007001552 A PE2007001552 A PE 2007001552A PE 20081116 A1 PE20081116 A1 PE 20081116A1
Authority
PE
Peru
Prior art keywords
alkyl
halo
methyl
arylpyridinyl
diaryl
Prior art date
Application number
PE2007001552A
Other languages
English (en)
Inventor
George Tetteh Magnus-Aryitey
Roger Bejamin Ruggeri
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20081116A1 publication Critical patent/PE20081116A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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  • Chemical & Material Sciences (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIARIL, DIPIRIDINIL Y ARILPIRIDINIL DE FORMULA (I) DONDE R ES H O JUNTO CON R1 Y EL N AL QUE ESTAN UNIDOS FORMAN UNA PIRROLIDINA O PIPERIDINA; R1 ES ALQUILO(C3-C8), ALQUENILO(C3-C8), HETEROCICLO DE 5 A 6 MIEMBROS, ENTRE OTROS; R2a Y R2b SON CADA UNO H; R3 ES H, HALO, ALQUILO(C1-C3), OH, ENTRE OTROS; R4 ES H, HALO, ALCOXI(C1-C3), METILO FLUOROSUSTITUIDO, ENTRE OTROS; V ES N O CR5, EN DONDE R5 ES H, HALO, ALQUILO(C1-C3), ENTRE OTROS; R6 ES H, ALQUILO(C1-C3), HALO, ENTRE OTROS; R7 ES H, F, OH, -C(O)NH2, ENTRE OTROS; R8 ES -C(O)NH2, -NHSO2ALQUILO(C1-C4), OH, ENTRE OTROS; R9 ES H, HIDROXILO, ALQUILO(C1-C3), HALO, ENTRE OTROS; W ES CR10 O N, EN DONDE R10 ES H, ALQUILO(C1-C3), HIDROXILO, CN, ENTRE OTROS; X ES N O CR11, EN DONDE R11 ES H, ALQUILO(C1-C3), HIDROXILO, HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-CLORO-3',5'-DIFLUORO-4'-({[2-(TETRAHIDRO-2H-PIRAN-4-IL)ETIL]-AMINO}-METIL)-BIFENIL-4-CARBOXAMIDA, 3',5'-DIFLUORO-2-METIL-4'-({[(2S)-TETRAHIDROFURAN-2-ILMETIL]-AMINO}-METIL)-BIFENIL-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES OPIOIDES µ, ? Y d SIENDO UTILES EN EL TRATAMIENTO DE LA OBESIDAD
PE2007001552A 2006-11-13 2007-11-12 Derivados de diaril, dipiridinil y arilpiridinil como antagonistas del receptor opioide PE20081116A1 (es)

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US86547906P 2006-11-13 2006-11-13

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PE20081116A1 true PE20081116A1 (es) 2008-09-07

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US (1) US7615651B2 (es)
EP (1) EP2084127A1 (es)
JP (1) JP2010509392A (es)
KR (1) KR20090064478A (es)
CN (1) CN101583593A (es)
AR (1) AR063790A1 (es)
AU (1) AU2007320906A1 (es)
CA (1) CA2669311C (es)
CL (1) CL2007003198A1 (es)
IL (1) IL198236A0 (es)
MX (1) MX2009004314A (es)
NO (1) NO20091649L (es)
PE (1) PE20081116A1 (es)
TW (1) TW200826927A (es)
UY (1) UY30706A1 (es)
WO (1) WO2008059335A1 (es)

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