EE9900584A - Neutraalse P1 spetsiifilisusrühmaga faktori Xa inhibiitorid - Google Patents
Neutraalse P1 spetsiifilisusrühmaga faktori Xa inhibiitoridInfo
- Publication number
- EE9900584A EE9900584A EEP199900584A EEP9900584A EE9900584A EE 9900584 A EE9900584 A EE 9900584A EE P199900584 A EEP199900584 A EE P199900584A EE P9900584 A EEP9900584 A EE P9900584A EE 9900584 A EE9900584 A EE 9900584A
- Authority
- EE
- Estonia
- Prior art keywords
- inhibitors
- neutral
- factor
- specificity group
- specificity
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87888597A | 1997-06-19 | 1997-06-19 | |
| US7669198P | 1998-02-27 | 1998-02-27 | |
| PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9900584A true EE9900584A (et) | 2000-08-15 |
Family
ID=26758382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900584A EE9900584A (et) | 1997-06-19 | 1998-06-18 | Neutraalse P1 spetsiifilisusrühmaga faktori Xa inhibiitorid |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0991625B1 (et) |
| JP (1) | JP2002507968A (et) |
| KR (1) | KR20010013977A (et) |
| AR (1) | AR015906A1 (et) |
| AT (1) | ATE296805T1 (et) |
| AU (1) | AU8150398A (et) |
| BR (1) | BR9810151A (et) |
| CA (1) | CA2290982A1 (et) |
| DE (1) | DE69830403T2 (et) |
| EA (1) | EA200000048A1 (et) |
| EE (1) | EE9900584A (et) |
| ES (1) | ES2239806T3 (et) |
| HR (1) | HRP980334A2 (et) |
| HU (1) | HUP0003906A2 (et) |
| IL (1) | IL133526A0 (et) |
| LV (1) | LV12516B (et) |
| NO (1) | NO996316L (et) |
| PL (1) | PL337831A1 (et) |
| PT (1) | PT991625E (et) |
| SI (1) | SI20208A (et) |
| SK (1) | SK174699A3 (et) |
| WO (1) | WO1998057937A2 (et) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998052944A1 (en) * | 1997-05-19 | 1998-11-26 | Sugen, Inc. | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
| US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
| WO1999032454A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| KR20010082515A (ko) | 1998-02-17 | 2001-08-30 | 우에노 도시오 | 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제 |
| EP1064270B1 (en) * | 1998-03-27 | 2004-10-06 | Bristol-Myers Squibb Pharma Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
| AU753360B2 (en) | 1998-07-31 | 2002-10-17 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
| WO2000039102A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| WO2000051998A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| AU4327600A (en) * | 1999-04-02 | 2000-10-23 | Du Pont Pharmaceuticals Company | Aryl sulfonyls as factor xa inhibitors |
| ES2391550T3 (es) | 1999-04-15 | 2012-11-27 | Bristol-Myers Squibb Company | Inhibidores cíclicos de la proteína tirosina quinasa |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| CN1454211A (zh) | 1999-07-16 | 2003-11-05 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Xa因子抑制剂的含氮杂双环化合物 |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
| WO2001032628A1 (en) * | 1999-11-03 | 2001-05-10 | Bristol-Myers Squibb Pharma Company | Cyano compounds as factor xa inhibitors |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
| CN1439008A (zh) * | 2000-06-23 | 2003-08-27 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为因子xa抑制剂的1－(杂芳环基－苯基)－稠合吡唑衍生物 |
| US6586418B2 (en) | 2000-06-29 | 2003-07-01 | Bristol-Myers Squibb Company | Thrombin or factor Xa inhibitors |
| WO2002037937A2 (en) | 2000-11-07 | 2002-05-16 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
| WO2002042273A2 (en) * | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
| TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
| CN1865258A (zh) | 2001-08-15 | 2006-11-22 | 纳幕尔杜邦公司 | 用于控制无脊椎害虫的邻位取代的芳基酰胺化合物 |
| RU2004107485A (ru) | 2001-08-15 | 2005-03-27 | Е.И.Дюпон де Немур энд Компани (US) | Орто-гетероциклические замещенные ариламиды для борьбы с беспозвоночными вредителями |
| DE60230421D1 (de) | 2001-08-16 | 2009-01-29 | Du Pont | Substituierte anthranilamide und ihre verwendung als pesticide |
| UA78232C2 (uk) | 2001-09-21 | 2007-03-15 | Брістол-Майерс Сквібб Компані | Лактамвмісні сполуки та їх похідні як інгібітори фактора ха |
| TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
| TW200724033A (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
| WO2003035073A1 (en) | 2001-10-25 | 2003-05-01 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
| CN100349890C (zh) | 2002-01-22 | 2007-11-21 | 纳幕尔杜邦公司 | 用于防治无脊椎害虫的喹唑啉(二)酮 |
| US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
| EP1511733A2 (en) | 2002-06-13 | 2005-03-09 | E.I. Du Pont De Nemours And Company | Pyrazole and pyrrole carboxamide insecticides |
| DE10229070A1 (de) * | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| AU2003295491B2 (en) | 2002-11-15 | 2009-10-08 | E.I. Du Pont De Nemours And Company | Novel anthranilamide insecticides |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
| US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| AU2003293914B2 (en) * | 2002-12-23 | 2010-09-23 | Panoptes Pharma Ges.M.B.H. | Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| EP1599463B1 (en) | 2003-01-28 | 2013-06-05 | E.I. Du Pont De Nemours And Company | Cyano anthranilamide insecticides |
| US7122557B2 (en) * | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
| CA2525325A1 (en) * | 2003-05-01 | 2004-11-18 | Abbott Laboratories | Pyrazole-amides and sulfonamides as sodium channel modulators |
| US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| BRPI0412259B1 (pt) | 2003-07-22 | 2019-08-20 | Astex Therapeutics Limited | Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica |
| CA2533598C (en) * | 2003-07-23 | 2012-09-11 | Synta Pharmaceuticals, Corp. | Method for modulating calcium ion-release-activated calcium ion channels |
| AU2004309279B2 (en) | 2003-12-26 | 2010-07-15 | Kyowa Kirin Co., Ltd. | Thiazole derivative |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| CA2560510C (en) | 2004-03-18 | 2009-10-13 | Pfizer Inc. | N-(1-arylpyrazol-4yl) sulfonamides and their use as parasiticides |
| GT200500179AA (es) | 2004-07-01 | 2008-10-29 | Mezclas sinergistas de agentes de antranilamida para el control de plagas de invertebrados | |
| WO2006027135A1 (en) * | 2004-09-06 | 2006-03-16 | F. Hoffmann-La Roche Ag | 4-aminomethyl benzamidine derivatives and their use as factor viiia inhibitors |
| AU2006211646B2 (en) | 2005-01-07 | 2012-09-20 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US20100280023A1 (en) | 2005-06-23 | 2010-11-04 | Kyowa Hakko Kogyo Co., Ltd. | Thiazole derivatives |
| AU2006271781A1 (en) * | 2005-07-15 | 2007-01-25 | F. Hoffmann-La Roche Ag | Novel heteroaryl fused cyclic amines |
| JP5039703B2 (ja) | 2005-08-24 | 2012-10-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用アントラニルアミド |
| TWI324908B (en) | 2006-01-05 | 2010-05-21 | Du Pont | Liquid formulations of carboxamide arthropodicides |
| MX2008009939A (es) * | 2006-01-31 | 2008-11-18 | Dongwha Pharmaceutical Ind Co | Derivados de benzamidina novedosos, procedimiento para la prepracion de los mismos y composicion farmaceutica que comprende los mismos. |
| EP2051707B1 (en) * | 2006-07-31 | 2013-07-17 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| CN101583593A (zh) | 2006-11-13 | 2009-11-18 | 辉瑞产品公司 | 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| MX2011005234A (es) | 2008-11-19 | 2011-06-01 | Schering Corp | Inhibidores de diacilglicerol aciltransferasa. |
| BR112012014683B1 (pt) * | 2009-12-15 | 2017-11-07 | Bayer Cropscience Ag | Process for the production of 5-pyrazolcarboxylic acid derivatives 1-alkyl- / 1-aryl-substituted and compound acid |
| CA2783801A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| JP5826856B2 (ja) * | 2010-10-20 | 2015-12-02 | ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド | ウイルスポリメラーゼ阻害剤 |
| WO2012081916A2 (ko) * | 2010-12-17 | 2012-06-21 | 한국화학연구원 | 인다졸 유도체 및 이를 함유하는 살충제 조성물 |
| WO2012130798A1 (de) | 2011-03-31 | 2012-10-04 | Bayer Cropscience Ag | Herbizid und fungizid wirksame 3-phenylisoxazolin-5-carboxamide und 3- phenylisoxazolin-5-thioamide |
| EP2697196A1 (en) | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| KR102057058B1 (ko) | 2011-10-03 | 2019-12-18 | 레스피버트 리미티드 | P38 map 키나제 저해제인 1-피라졸릴-3-(4-((2-아닐리노피리미딘-4-일)옥시)나프탈렌-1-일) 우레아 |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| US9516880B2 (en) * | 2012-09-25 | 2016-12-13 | Bayer Cropscience Ag | Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides |
| CR20190436A (es) | 2012-10-02 | 2019-10-29 | Bayer Cropscience Ag | COMPUESTOS HETEROCICLICOS COMO PLAGUICIDAS (Divisional 2015-0182) |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| LT3828173T (lt) | 2014-03-07 | 2022-11-10 | Biocryst Pharmaceuticals, Inc. | Pakeistieji pirazolai kaip žmogaus plazmos kalikreino inhibitoriai |
| CN104086498B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 末端取代的三唑希夫碱类结构的化合物、其制备方法和用途 |
| CN104086492B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 抗血栓化合物、其制备方法和用途 |
| CN104072435B (zh) * | 2014-07-23 | 2015-11-04 | 张远强 | 双烷基取代的四氮唑苯乙酮化合物和用途 |
| CN104086493B (zh) * | 2014-07-23 | 2016-05-18 | 张远强 | 末端取代的苯基三唑希夫碱结构的化合物及其用途 |
| CN104072436B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 对位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104072439B (zh) * | 2014-07-23 | 2015-11-04 | 张远强 | 卤素取代的四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104086497B (zh) * | 2014-07-23 | 2016-03-02 | 张远强 | 三唑希夫碱类化合物、其制备方法和用途 |
| CN104072434B (zh) * | 2014-07-23 | 2015-12-02 | 张远强 | 间位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104086501B (zh) * | 2014-07-23 | 2016-02-17 | 张远强 | 一种par-1拮抗剂、其制备方法和用途 |
| CN104072438B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 二烷氧代四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104072431B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 烷氧基取代的苯基三唑希夫碱结构的化合物及用途 |
| CN104072437B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 双取代的四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104086502B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 卤代四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104086503B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | Par-1拮抗剂及其用途 |
| CN104072432B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 含苯基取代三唑希夫碱类结构的化合物、其制备方法和用途 |
| CN104086500B (zh) * | 2014-07-23 | 2015-08-26 | 张远强 | 一种par-1拮抗剂及其用途 |
| LT3186232T (lt) | 2014-08-29 | 2019-07-10 | Torrent Pharmaceuticals Limited | P38 map kinazė, slopinanti indanilo karbamido junginius |
| CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
| CN110799511B (zh) | 2017-06-13 | 2023-09-01 | 拜耳公司 | 除草活性的四氢和二氢呋喃甲酰胺的3-苯基异噁唑啉-5-甲酰胺 |
| PL3638665T3 (pl) | 2017-06-13 | 2021-12-27 | Bayer Aktiengesellschaft | Chwastobójczo skuteczne 3-fenyloizoksazolino-5-karboksyamidy kwasów i estrów tetrahydro- i dihydrofuranokarboksylowych |
| US20200369630A1 (en) | 2017-08-17 | 2020-11-26 | Bayer Aktiengesellschaft | Herbicidally active 3-phenyl-5-trifluoromethylisoxazoline-5-carboxamides of cyclopentylcarboxylic acids and esters |
| DK3743411T3 (da) | 2018-01-25 | 2023-02-13 | Bayer Ag | Herbicidt virksomt 3-phenylisoxazolin-5-carboxamider af cyclopentenylcarbonsyrederivater |
| US12185723B2 (en) | 2019-03-12 | 2025-01-07 | Bayer Aktiengesellschaft | Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenylcarboxylic esters |
| JP2023509452A (ja) | 2020-01-03 | 2023-03-08 | バーグ エルエルシー | がんを処置するためのｕｂｅ２ｋモジュレータとしての多環式アミド |
| WO2022234271A1 (en) * | 2021-05-05 | 2022-11-10 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4134987A (en) * | 1976-01-14 | 1979-01-16 | Huppatz John L | Compounds and compositions |
| DE3065860D1 (en) * | 1979-02-22 | 1984-01-19 | Monsanto Co | Thermolysis of 2-(3-aryl-isoxazol-5-yl)benzoic acids, salts and halides from 3'-(aryl)-spiro(isobenzofuran-1(3h),5'(4'h)isoxazol)-3-ones |
| US4226877A (en) * | 1979-05-14 | 1980-10-07 | Abbott Laboratories | Pyrazoles active in the central nervous system |
| EP0028489B1 (en) | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| DE3420985A1 (de) * | 1983-10-15 | 1985-04-25 | Bayer Ag, 5090 Leverkusen | Substituierte 5-acylamino-1-phenylpyrazole |
| IL73419A (en) * | 1983-11-07 | 1988-02-29 | Lilly Co Eli | 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them |
| DE3540839A1 (de) * | 1985-11-18 | 1987-05-27 | Bayer Ag | 1-aryl-pyrazole |
| DE3633840A1 (de) * | 1986-10-04 | 1988-04-14 | Hoechst Ag | Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener |
| DE3706993A1 (de) * | 1987-03-05 | 1988-09-15 | Bayer Ag | 5-amino-3-halogenalkyl-1-aryl-pyrazole |
| JPS6425763A (en) * | 1987-04-24 | 1989-01-27 | Mitsubishi Chem Ind | Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| DE3808896A1 (de) * | 1988-03-17 | 1989-09-28 | Hoechst Ag | Pflanzenschuetzende mittel auf basis von pyrazolcarbonsaeurederivaten |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| DE4013723A1 (de) * | 1990-04-28 | 1991-10-31 | Basf Ag | 5-(1,2,4-triazol-1-ylmethyl)-isoxazoline |
| GB9017694D0 (en) | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
| DE69132006T2 (de) * | 1990-11-30 | 2000-08-03 | Otsuka Pharmaceutical Co., Ltd. | Thiazolederivate als inhibitoren von aktivem sauerstoff |
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AU672802B2 (en) * | 1992-07-24 | 1996-10-17 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
| US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
| US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| FI962184L (fi) * | 1993-11-24 | 1996-05-23 | Du Pont Merck Pharma | Uusia isoksatsoliini- ja isoksatsolifibrinogeenireseptoriantagonisteja |
| DK0730589T3 (da) * | 1993-11-24 | 1999-02-01 | Du Pont Pharm Co | Isoxazolinforbindelser, der er nyttige som fibrinogenreceptorantagonister |
| US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| DE4405207A1 (de) * | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
| DK0813525T3 (da) * | 1995-03-10 | 2004-02-16 | Berlex Lab | Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter |
| IL118007A0 (en) * | 1995-05-24 | 1996-08-04 | Du Pont Merck Pharma | Isoxazoline compounds pharmaceutical compositions containing them and their use |
-
1998
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Withdrawn
- 1998-06-18 EP EP98931355A patent/EP0991625B1/en not_active Revoked
- 1998-06-18 BR BR9810151-0A patent/BR9810151A/pt not_active IP Right Cessation
- 1998-06-18 PT PT98931355T patent/PT991625E/pt unknown
- 1998-06-18 ES ES98931355T patent/ES2239806T3/es not_active Expired - Lifetime
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
- 1998-06-18 HR HR60/076,691A patent/HRP980334A2/hr not_active Application Discontinuation
- 1998-06-18 EE EEP199900584A patent/EE9900584A/et unknown
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en not_active Ceased
- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-18 AU AU81503/98A patent/AU8150398A/en not_active Abandoned
- 1998-06-18 CA CA002290982A patent/CA2290982A1/en not_active Abandoned
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-19 AR ARP980102939A patent/AR015906A1/es unknown
-
1999
- 1999-12-16 LV LVP-99-177A patent/LV12516B/en unknown
- 1999-12-17 NO NO996316A patent/NO996316L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0991625B1 (en) | 2005-06-01 |
| SI20208A (sl) | 2000-10-31 |
| DE69830403T2 (de) | 2006-02-02 |
| HRP980334A2 (en) | 1999-04-30 |
| AU8150398A (en) | 1999-01-04 |
| ES2239806T3 (es) | 2005-10-01 |
| LV12516A (en) | 2000-07-20 |
| ATE296805T1 (de) | 2005-06-15 |
| EP0991625A2 (en) | 2000-04-12 |
| LV12516B (en) | 2001-03-20 |
| CA2290982A1 (en) | 1998-12-23 |
| PL337831A1 (en) | 2000-09-11 |
| KR20010013977A (ko) | 2001-02-26 |
| AR015906A1 (es) | 2001-05-30 |
| NO996316D0 (no) | 1999-12-17 |
| SK174699A3 (en) | 2000-08-14 |
| WO1998057937A3 (en) | 1999-03-18 |
| WO1998057937A2 (en) | 1998-12-23 |
| PT991625E (pt) | 2005-10-31 |
| BR9810151A (pt) | 2000-08-08 |
| IL133526A0 (en) | 2001-04-30 |
| NO996316L (no) | 1999-12-17 |
| JP2002507968A (ja) | 2002-03-12 |
| HUP0003906A2 (hu) | 2001-05-28 |
| EA200000048A1 (ru) | 2000-08-28 |
| DE69830403D1 (de) | 2005-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE9900584A (et) | Neutraalse P1 spetsiifilisusrühmaga faktori Xa inhibiitorid | |
| FI964317A7 (fi) | Tekijän-Xa-inhibiittoreita | |
| NO20003808L (no) | Substituerte oksoazaheterosyklylfaktor Xa inhibitorer | |
| NO980097L (no) | Celleadhesjonsinhibitorer | |
| DK1027332T3 (da) | Hidtil ukendte lactametalloproteaseinhibitorer | |
| FI965019A7 (fi) | Entsyymi-inhibiittoreita | |
| DE69817148D1 (de) | Schallschutzwand mit entkoppler | |
| DE69921358D1 (de) | Stickstoffhaltige heterobicyclen als faktor-xa-hemmer | |
| DK0884060T3 (da) | Manchetforsynet rør | |
| DK1344524T3 (da) | Refluksinhibitorer | |
| DE69801014D1 (de) | Wellrohr | |
| DK0958287T3 (da) | Sulfamidmetalloprotease-inhibitorer | |
| NO20003256D0 (no) | ACE inhibitor-MMP inhibitor kombinasjoner | |
| NO20002852D0 (no) | Rørforbindelse | |
| FI964781A7 (fi) | Uusia elastaasi-inhibiittoreita | |
| FI973929A0 (fi) | WOF inhibitor | |
| LT99146A (en) | Inhibitors of factor xa with a neutral p1 specificity group | |
| EP1007548A4 (en) | THROMBIN INHIBITOR FROM TSE-TSE FLY | |
| DE69808480D1 (de) | Dudelsackpfeifen | |
| NO970605L (no) | Kombinert r°rverkt°y | |
| NO975425L (no) | R°rledningspµl I | |
| NO975426L (no) | R°rledningspµl II | |
| KR970058586U (ko) | 조립식 파이프 | |
| KR970058585U (ko) | 조립식 파이프 | |
| NO976015D0 (no) | Rörlednings-fundamentering |