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PE20081786A1 - 1,1-DIOXO-1-TIA-5,10-DIAZADIBENZOCICLOHEPTENES USEFUL AS INHIBITORS OF HEPATITIS C VIRUS - Google Patents

1,1-DIOXO-1-TIA-5,10-DIAZADIBENZOCICLOHEPTENES USEFUL AS INHIBITORS OF HEPATITIS C VIRUS

Info

Publication number
PE20081786A1
PE20081786A1 PE2008000333A PE2008000333A PE20081786A1 PE 20081786 A1 PE20081786 A1 PE 20081786A1 PE 2008000333 A PE2008000333 A PE 2008000333A PE 2008000333 A PE2008000333 A PE 2008000333A PE 20081786 A1 PE20081786 A1 PE 20081786A1
Authority
PE
Peru
Prior art keywords
tia
dioxo
hepatitis
virus
inhibitors
Prior art date
Application number
PE2008000333A
Other languages
Spanish (es)
Inventor
Raboisso Pierre Jean-Marie Bernard
Katie Ingrid Eduard Amssoms
Koen Vandyck
Carlo Willy Maurice Boutton
Origene Nyanguile
Lory Pedro Miguel Jales
Gowan David Craig Mcc
Sandrine Maraie Helene Vendeville
Den Broeck Walter Marcel Mathilde Van
Maxwell David Cummings
Stefaan Julien Last
Klara Rombauts
Abdellah Tahri
Lili Hu
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of PE20081786A1 publication Critical patent/PE20081786A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1a ES H, HIDROXI, AMINO, HALO, ENTRE OTROS; R1b ES H, HIDROXI, AMINO, ALCOXI, ENTRE OTROS; R2 ES H, -C(=O)-, -C(=O)-R5, ENTRE OTROS; R3 ES ALQUILO C1-C6 SUSTITUIDO O NO CON CICLOALQUILO C3-C7, ARILO, HET, ENTRE OTROS; R4a Y R4b SON CADA UNO H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 10-ACETIL-11-(2,4-DICLOROFENIL)-3,3-DIMETIL-1,1-DIOXO-1,2,3,4,5,11-HEXAHIDRO-1LAMBDA6-TIA-5,10-DIAZADIBENZO[a,d]CICLOHEPTENO; [11-(4-BENCILXOI-2-FLUORO-FENIL)-3,3-DIMETIL-1,1-DIOXO-1,2,3,4,5,11-HEXAHIDRO-1LAMBDA6-TIA-5,10-DIAZA-DIBENZO[a,d]CICLOHEPTEN-10-IL]-PIRIDIN-2-IL-METANONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DEL VIRUS DE LA HEPATITIS CREFERS TO A COMPOUND OF FORMULA I, WHERE R1a IS H, HYDROXY, AMINO, HALO, AMONG OTHERS; R1b IS H, HYDROXY, AMINO, ALCOXY, AMONG OTHERS; R2 IS H, -C (= O) -, -C (= O) -R5, AMONG OTHERS; R3 IS C1-C6 ALKYL, SUBSTITUTED OR NOT WITH C3-C7 CYCLOALKYL, ARYL, HET, AMONG OTHERS; R4a AND R4b ARE EACH H, C1-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 10-ACETYL-11- (2,4-DICHLOROPHENYL) -3,3-DIMETHYL-1,1-DIOXO-1,2,3,4,5,11-HEXAHYDRO-1LAMBDA6-TIA-5, 10-DIAZADIBENZO [a, d] CYCLOHEPTENE; [11- (4-BENZYLXOI-2-FLUORO-PHENYL) -3,3-DIMETHYL-1,1-DIOXO-1,2,3,4,5,11-HEXAHYDRO-1LAMBDA6-TIA-5,10-DIAZA -DIBENZO [a, d] CYCLOHEPTEN-10-IL] -PYRIDIN-2-IL-METHANONE; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE INHIBITORS OF THE HEPATITIS C VIRUS

PE2008000333A 2007-02-16 2008-02-15 1,1-DIOXO-1-TIA-5,10-DIAZADIBENZOCICLOHEPTENES USEFUL AS INHIBITORS OF HEPATITIS C VIRUS PE20081786A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07102520 2007-02-16

Publications (1)

Publication Number Publication Date
PE20081786A1 true PE20081786A1 (en) 2008-12-18

Family

ID=38515419

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000333A PE20081786A1 (en) 2007-02-16 2008-02-15 1,1-DIOXO-1-TIA-5,10-DIAZADIBENZOCICLOHEPTENES USEFUL AS INHIBITORS OF HEPATITIS C VIRUS

Country Status (6)

Country Link
AR (1) AR065374A1 (en)
CL (1) CL2008000491A1 (en)
PE (1) PE20081786A1 (en)
TW (1) TW200848057A (en)
UY (1) UY30922A1 (en)
WO (1) WO2008099020A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008128166A1 (en) 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds
WO2021030278A1 (en) * 2019-08-12 2021-02-18 Aligos Therapeutics, Inc. Bicyclic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60042425D1 (en) * 1999-04-30 2009-07-30 Univ Michigan Use of benzodiazepines for the treatment of autoimmune diseases, inflammation, neoplasia, viral infections and atherosclerosis
US7662809B2 (en) * 2004-10-26 2010-02-16 Istituto Di Richerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents

Also Published As

Publication number Publication date
WO2008099020A1 (en) 2008-08-21
AR065374A1 (en) 2009-06-03
TW200848057A (en) 2008-12-16
CL2008000491A1 (en) 2008-08-22
UY30922A1 (en) 2008-09-02

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