AR070487A1 - DERIVATIVES OF 3- METHYL-IMIDAZO - (1,2-B) - PIRIDAZINA - Google Patents
DERIVATIVES OF 3- METHYL-IMIDAZO - (1,2-B) - PIRIDAZINAInfo
- Publication number
- AR070487A1 AR070487A1 ARP090100659A ARP090100659A AR070487A1 AR 070487 A1 AR070487 A1 AR 070487A1 AR P090100659 A ARP090100659 A AR P090100659A AR P090100659 A ARP090100659 A AR P090100659A AR 070487 A1 AR070487 A1 AR 070487A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- formula
- substituted
- compound
- halogen
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- YDVJBLJCSLVMSY-UHFFFAOYSA-N carbamoyl cyanide Chemical compound NC(=O)C#N YDVJBLJCSLVMSY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la formula (1) para la fabricacion de un medicamento para el tratamiento de estas enfermedades; a composiciones farmacéuticas que comprenden un compuesto de la formula (1), opcionalmente en la presencia de un componente de combinacion; y a procesos para la preparacion de un compuesto de la formula (1). Reivindicacion 1: Un compuesto de la formula (1) en donde: R1 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido, cicloalquilo insustituido o sustituido, alquilo insustituido o sustituido, alcoxilo insustituido o sustituido, ciano, carboxamida, o halogeno; R2 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido; R3 representa H, deuterio, alquilo inferior, y R3' representa H, deuterio, alquilo inferior, halogeno, hidroxilo, o R3 representa halogeno, y R3' representa halogeno, o R3 y R3' representan, junto con el átomo de carbono con el que están unidos, cicloalquilo o vinilo; A1 representa ya sea un enlace directo, un grupo -SO2-, o bien un grupo de formula (2) en donde el enlace marcado * está unido a R1; n representa 0 o 1; m representa 0, 1, 2, 3, 4 o 5; R4 representa H o alquilo insustituido; R5 representa H o alquilo insustituido; R5' representa H o alquilo insustituido; A2 representa O o NR4; o una sal del mismo.A process for the treatment of the human or animal body, in particular with respect to a disease mediated by tyrosine kinase c-Met; to the use of a compound of the formula (1) for the manufacture of a medicament for the treatment of these diseases; to pharmaceutical compositions comprising a compound of the formula (1), optionally in the presence of a combination component; and to processes for the preparation of a compound of the formula (1). Claim 1: A compound of the formula (1) wherein: R 1 represents unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkyl, unsubstituted or substituted alkoxy, cyano, carboxamide, or halogen; R2 represents unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl; R3 represents H, deuterium, lower alkyl, and R3 'represents H, deuterium, lower alkyl, halogen, hydroxyl, or R3 represents halogen, and R3' represents halogen, or R3 and R3 'represent, together with the carbon atom with the which are attached, cycloalkyl or vinyl; A1 represents either a direct link, a group -SO2-, or a group of formula (2) in which the labeled link * is attached to R1; n represents 0 or 1; m represents 0, 1, 2, 3, 4 or 5; R4 represents H or unsubstituted alkyl; R5 represents H or unsubstituted alkyl; R5 'represents H or unsubstituted alkyl; A2 represents O or NR4; or a salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152068 | 2008-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070487A1 true AR070487A1 (en) | 2010-04-07 |
Family
ID=39672115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100659A AR070487A1 (en) | 2008-02-28 | 2009-02-26 | DERIVATIVES OF 3- METHYL-IMIDAZO - (1,2-B) - PIRIDAZINA |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8822468B2 (en) |
| EP (1) | EP2265614A1 (en) |
| JP (1) | JP5576802B2 (en) |
| KR (1) | KR20100128305A (en) |
| CN (1) | CN102015716B (en) |
| AR (1) | AR070487A1 (en) |
| AU (1) | AU2009218459A1 (en) |
| BR (1) | BRPI0908504A2 (en) |
| CA (1) | CA2717034A1 (en) |
| CL (1) | CL2009000443A1 (en) |
| CO (1) | CO6300957A2 (en) |
| CR (1) | CR11620A (en) |
| DO (1) | DOP2010000263A (en) |
| EA (1) | EA201001365A1 (en) |
| EC (1) | ECSP10010427A (en) |
| IL (1) | IL207434A0 (en) |
| MA (1) | MA32167B1 (en) |
| MX (1) | MX2010009414A (en) |
| NI (1) | NI201000145A (en) |
| PE (1) | PE20091468A1 (en) |
| SM (1) | SMAP201000112A (en) |
| TW (1) | TW200940545A (en) |
| UY (1) | UY31676A1 (en) |
| WO (1) | WO2009106577A1 (en) |
| ZA (1) | ZA201005602B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| UY32049A (en) * | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | CMET INHIBITORS |
| US20110053968A1 (en) * | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| BR112012003262A8 (en) | 2009-08-12 | 2016-05-17 | Novartis Ag | Heterocyclic Hydrazone Compounds and Their Uses to Treat Cancer and Inflammation |
| BR112012008061A2 (en) | 2009-08-20 | 2016-03-01 | Novartis Ag | heterocyclic oxime compounds |
| PE20130375A1 (en) | 2009-12-31 | 2013-04-10 | Hutchison Medipharma Ltd | TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINE COMPOUNDS, C-MET INHIBITORS AND COMPOSITIONS THEREOF |
| US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
| WO2012003338A1 (en) * | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| AR085183A1 (en) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | COMPOUND 6- (1-METHYL-1H-PIRAZOL-4-IL) -3- (2-METHYL-2H-INDAZOL-5-ILTIO) - [1,2,4] TRIAZOL [4,3-B] PIRIDAZINE, PHARMACEUTICAL COMPOSITION THAT UNDERSTAND AND USE IT TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT CANCER |
| UY33597A (en) | 2010-09-09 | 2012-04-30 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK |
| WO2012175591A1 (en) * | 2011-06-22 | 2012-12-27 | Bayer Intellectual Property Gmbh | Heterocyclyl aminoimidazopyridazines |
| CN103958509B (en) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 6-Substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-A]pyridine compounds as tyrosine kinase inhibitors |
| EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
| CN103122000B (en) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | High-selectivity c-Met kinase inhibitor used as antitumor drug |
| RS56720B1 (en) | 2012-11-19 | 2018-03-30 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014138692A1 (en) | 2013-03-07 | 2014-09-12 | Califia Bio, Inc. | Mixed lineage kinase inhibitors and method of treatments |
| AR097543A1 (en) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPOUNDS BASED ON IMIDAZO [1,2-b] PIRIDAZINE, COMPOSITIONS THAT INCLUDE THEM AND THEIR METHODS OF USE |
| CN105326793A (en) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术（太仓）有限公司 | Solid dispersion containing c-Met kinase inhibitor and preparation method and application of solid dispersion |
| CN107108633B (en) * | 2014-12-19 | 2020-05-12 | 詹森药业有限公司 | Heterocyclyl-linked imidazopyridazine derivatives as PI3K β inhibitors |
| US10087187B2 (en) * | 2014-12-19 | 2018-10-02 | Janssen Pharmaceutica Nv | Imidazopyridazine derivatives as PI3KB inhibitors |
| EP3512852B1 (en) * | 2016-09-16 | 2024-06-26 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Traf 6 inhibitors |
| EP3558304A2 (en) * | 2016-12-23 | 2019-10-30 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| WO2018138050A1 (en) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Condensed bicyclic heterocyclene derivatives as pest control agents |
| US11584744B2 (en) * | 2017-06-23 | 2023-02-21 | University Of Washington | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them |
| JP7296992B2 (en) * | 2018-05-28 | 2023-06-23 | エフ． ホフマン－ラ ロシュ アーゲー | Novel oxoquinolidine compounds for the treatment and prevention of bacterial infections |
| JP7712932B2 (en) * | 2019-12-18 | 2025-07-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | LIN28 INHIBITORS AND METHODS OF USE THEREOF |
| CN119081395B (en) * | 2024-09-07 | 2025-03-18 | 广东环塑众创实业有限公司 | A kind of high temperature resistant nylon engineering plastic and preparation method thereof |
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-
2009
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/en not_active Application Discontinuation
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/en not_active Expired - Fee Related
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/en not_active Ceased
- 2009-02-26 AR ARP090100659A patent/AR070487A1/en unknown
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/en not_active Ceased
- 2009-02-26 CA CA2717034A patent/CA2717034A1/en not_active Abandoned
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/en not_active IP Right Cessation
- 2009-02-26 UY UY031676A patent/UY31676A1/en not_active Application Discontinuation
- 2009-02-26 EA EA201001365A patent/EA201001365A1/en unknown
- 2009-02-26 EP EP09714429A patent/EP2265614A1/en not_active Withdrawn
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/en not_active Expired - Fee Related
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/en not_active Application Discontinuation
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/en unknown
- 2009-02-27 TW TW098106564A patent/TW200940545A/en unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/en not_active Application Discontinuation
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/en unknown
- 2010-08-27 NI NI201000145A patent/NI201000145A/en unknown
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/en unknown
- 2010-08-27 CO CO10106017A patent/CO6300957A2/en not_active Application Discontinuation
- 2010-09-24 MA MA33198A patent/MA32167B1/en unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5576802B2 (en) | 2014-08-20 |
| BRPI0908504A2 (en) | 2015-08-11 |
| US20090264406A1 (en) | 2009-10-22 |
| SMAP201000112A (en) | 2010-11-12 |
| MX2010009414A (en) | 2010-09-24 |
| AU2009218459A1 (en) | 2009-09-03 |
| TW200940545A (en) | 2009-10-01 |
| EA201001365A1 (en) | 2011-04-29 |
| UY31676A1 (en) | 2009-09-30 |
| ECSP10010427A (en) | 2010-09-30 |
| NI201000145A (en) | 2011-03-02 |
| CR11620A (en) | 2010-10-08 |
| IL207434A0 (en) | 2010-12-30 |
| ZA201005602B (en) | 2011-04-28 |
| WO2009106577A1 (en) | 2009-09-03 |
| EP2265614A1 (en) | 2010-12-29 |
| CO6300957A2 (en) | 2011-07-21 |
| JP2011513279A (en) | 2011-04-28 |
| CN102015716A (en) | 2011-04-13 |
| DOP2010000263A (en) | 2010-09-30 |
| CN102015716B (en) | 2014-09-17 |
| KR20100128305A (en) | 2010-12-07 |
| PE20091468A1 (en) | 2009-10-22 |
| MA32167B1 (en) | 2011-03-01 |
| US8822468B2 (en) | 2014-09-02 |
| CA2717034A1 (en) | 2009-09-03 |
| CL2009000443A1 (en) | 2010-09-10 |
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