PE20081482A1 - Capsulas de gelatina que contienen un acido - Google Patents
Capsulas de gelatina que contienen un acidoInfo
- Publication number
- PE20081482A1 PE20081482A1 PE2007001792A PE2007001792A PE20081482A1 PE 20081482 A1 PE20081482 A1 PE 20081482A1 PE 2007001792 A PE2007001792 A PE 2007001792A PE 2007001792 A PE2007001792 A PE 2007001792A PE 20081482 A1 PE20081482 A1 PE 20081482A1
- Authority
- PE
- Peru
- Prior art keywords
- acid
- composition
- refers
- filling material
- gelatin capsule
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 239000001828 Gelatine Substances 0.000 title 1
- 239000002775 capsule Substances 0.000 title 1
- 229920000159 gelatin Polymers 0.000 title 1
- 235000019322 gelatine Nutrition 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000007903 gelatin capsule Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- 102000003915 DNA Topoisomerases Human genes 0.000 abstract 1
- 108090000323 DNA Topoisomerases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 235000011087 fumaric acid Nutrition 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004530 micro-emulsion Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA EN FORMA DE CAPSULA DE GELATINA LA CUAL COMPRENDE: a) UNA CUBIERTA DE CAPSULA DE GELATINA BLANDA Y b) UN MATERIAL, SEMILIQUIDO O LIQUIDO COMO MICROEMULSION, DE RELLENO; EL CUAL CONTIENE ENTRE 0.01% AL 20% DE UN ACIDO, SELECCIONADO DE ACIDO FUMARICO, ACIDO FOSFORICO, ACIDO MALICO, ACIDO ASCORBICO, ENTRE OTROS, EN EL QUE DICHO ACIDO MIGRA DESDE EL MATERIAL DE RELLENO HACIA LA CUBIERTA DE CAPSULA E INHIBE LA FORMACION DE PELICULA; EL AGENTE ACTIVO PUEDE ESTAR PRESENTE EN HASTA UN 20% DEL PESO TOTAL DE LA COMPOSICION. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION CONTIENE PREFERENTEMENTE 7-TERBUTOXI-IMINO-METIL-CAMPTOTECINA QUE ES UN INHIBIDOR DE TOPOISOMERASA I, UTIL EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06126698 | 2006-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081482A1 true PE20081482A1 (es) | 2008-12-23 |
Family
ID=37890457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001792A PE20081482A1 (es) | 2006-12-20 | 2007-12-14 | Capsulas de gelatina que contienen un acido |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100068265A1 (es) |
| EP (1) | EP2120889A1 (es) |
| JP (1) | JP2010513351A (es) |
| KR (1) | KR20090094373A (es) |
| CN (1) | CN101563072A (es) |
| AR (1) | AR064419A1 (es) |
| AU (1) | AU2007334856A1 (es) |
| BR (1) | BRPI0720489A2 (es) |
| CA (1) | CA2672400A1 (es) |
| CL (1) | CL2007003698A1 (es) |
| MX (1) | MX2009006735A (es) |
| PE (1) | PE20081482A1 (es) |
| TW (1) | TW200833375A (es) |
| UY (1) | UY30810A1 (es) |
| WO (1) | WO2008074479A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012002464A1 (ja) * | 2010-06-30 | 2012-01-05 | 持田製薬株式会社 | ω3脂肪酸の配合製剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
| DE4001622A1 (de) * | 1990-01-20 | 1991-07-25 | Thomae Gmbh Dr K | Orale arzneimittelformen von pimobendan |
| US5620704A (en) * | 1994-11-07 | 1997-04-15 | Warner-Lambert Company | Process for stabilizing gelatin products |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| WO1997033568A1 (en) * | 1996-03-12 | 1997-09-18 | Novartis Ag | Filled gelatin capsules having a reduced degree of cross-linking |
| US6228894B1 (en) * | 1998-04-17 | 2001-05-08 | Enhanced Derm Technologies, Inc. | Softgel-compatible composition containing retinol |
| ES2302926T5 (es) * | 2002-04-25 | 2012-08-23 | Banner Pharmacaps, Inc. | Cápsula blanda masticable |
| EP1549299B1 (en) * | 2002-06-05 | 2014-08-20 | IVAX Pharmaceuticals s.r.o. | Reduction of gelatin cross-linking |
-
2007
- 2007-12-14 PE PE2007001792A patent/PE20081482A1/es not_active Application Discontinuation
- 2007-12-18 JP JP2009541867A patent/JP2010513351A/ja active Pending
- 2007-12-18 KR KR1020097014926A patent/KR20090094373A/ko not_active Withdrawn
- 2007-12-18 AR ARP070105696A patent/AR064419A1/es unknown
- 2007-12-18 WO PCT/EP2007/011138 patent/WO2008074479A1/en not_active Ceased
- 2007-12-18 CN CNA2007800472119A patent/CN101563072A/zh active Pending
- 2007-12-18 MX MX2009006735A patent/MX2009006735A/es not_active Application Discontinuation
- 2007-12-18 AU AU2007334856A patent/AU2007334856A1/en not_active Abandoned
- 2007-12-18 EP EP07856861A patent/EP2120889A1/en not_active Withdrawn
- 2007-12-18 US US12/518,958 patent/US20100068265A1/en not_active Abandoned
- 2007-12-18 BR BRPI0720489-2A patent/BRPI0720489A2/pt not_active Application Discontinuation
- 2007-12-18 CA CA002672400A patent/CA2672400A1/en not_active Abandoned
- 2007-12-19 CL CL200703698A patent/CL2007003698A1/es unknown
- 2007-12-19 TW TW096148801A patent/TW200833375A/zh unknown
- 2007-12-19 UY UY30810A patent/UY30810A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY30810A1 (es) | 2008-07-31 |
| AR064419A1 (es) | 2009-04-01 |
| KR20090094373A (ko) | 2009-09-04 |
| CN101563072A (zh) | 2009-10-21 |
| WO2008074479A1 (en) | 2008-06-26 |
| JP2010513351A (ja) | 2010-04-30 |
| EP2120889A1 (en) | 2009-11-25 |
| CA2672400A1 (en) | 2008-06-26 |
| US20100068265A1 (en) | 2010-03-18 |
| AU2007334856A1 (en) | 2008-06-26 |
| BRPI0720489A2 (pt) | 2014-02-04 |
| CL2007003698A1 (es) | 2008-07-18 |
| MX2009006735A (es) | 2009-06-30 |
| TW200833375A (en) | 2008-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |