CL2013002700A1 - Cápsula suave ingerible que contiene inositol y excipientes, o inositol, excipientes y al menos un principio activo adicional, tal como ácido fólico, polifenoles de cocoa, genisteína, l-arginina, vitamina e, selenio, n-acetilcisteína y melatonina; útil para el tratamiento del ovario poliquístico, resistencia a la insulina y otros - Google Patents
Cápsula suave ingerible que contiene inositol y excipientes, o inositol, excipientes y al menos un principio activo adicional, tal como ácido fólico, polifenoles de cocoa, genisteína, l-arginina, vitamina e, selenio, n-acetilcisteína y melatonina; útil para el tratamiento del ovario poliquístico, resistencia a la insulina y otrosInfo
- Publication number
- CL2013002700A1 CL2013002700A1 CL2013002700A CL2013002700A CL2013002700A1 CL 2013002700 A1 CL2013002700 A1 CL 2013002700A1 CL 2013002700 A CL2013002700 A CL 2013002700A CL 2013002700 A CL2013002700 A CL 2013002700A CL 2013002700 A1 CL2013002700 A1 CL 2013002700A1
- Authority
- CL
- Chile
- Prior art keywords
- excipients
- inositol
- treatment
- insulin resistance
- genistein
- Prior art date
Links
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000367 inositol Drugs 0.000 title abstract 3
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 title abstract 3
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 3
- 206010022489 Insulin Resistance Diseases 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title 2
- 239000000546 pharmaceutical excipient Substances 0.000 title 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 title 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title 1
- 206010036049 Polycystic ovaries Diseases 0.000 title 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title 1
- 235000009470 Theobroma cacao Nutrition 0.000 title 1
- 229930003427 Vitamin E Natural products 0.000 title 1
- 229960004308 acetylcysteine Drugs 0.000 title 1
- 239000013543 active substance Substances 0.000 title 1
- 244000240602 cacao Species 0.000 title 1
- 229960000304 folic acid Drugs 0.000 title 1
- 235000019152 folic acid Nutrition 0.000 title 1
- 239000011724 folic acid Substances 0.000 title 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title 1
- 235000006539 genistein Nutrition 0.000 title 1
- 229940045109 genistein Drugs 0.000 title 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 title 1
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 title 1
- 229940124280 l-arginine Drugs 0.000 title 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title 1
- 229960003987 melatonin Drugs 0.000 title 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 title 1
- 150000008442 polyphenolic compounds Chemical class 0.000 title 1
- 235000013824 polyphenols Nutrition 0.000 title 1
- 229910052711 selenium Inorganic materials 0.000 title 1
- 239000011669 selenium Substances 0.000 title 1
- 229940091258 selenium supplement Drugs 0.000 title 1
- 239000007901 soft capsule Substances 0.000 title 1
- 235000019165 vitamin E Nutrition 0.000 title 1
- 229940046009 vitamin E Drugs 0.000 title 1
- 239000011709 vitamin E Substances 0.000 title 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSICION FARMACEUTICA QUE COMPRENDE INOSITOL O UN ISOMERO, EN UN VEHICULO QUE COMPRENDE GELATINA, GLICEROL O SUS MEZCLAS; PROCEDIMIENTO DE FABRICACION; Y SU USO EN EL TRATAMIENTO O PREVENCION DE SINDROME DE OVARIO POLIQUISTICO, RESISTENCIA A LA INSULINA, ENTRE OTROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000445A ITMI20110445A1 (it) | 2011-03-22 | 2011-03-22 | Formulazione farmaceutica comprendente inositolo. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002700A1 true CL2013002700A1 (es) | 2014-07-11 |
Family
ID=43977111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002700A CL2013002700A1 (es) | 2011-03-22 | 2013-09-23 | Cápsula suave ingerible que contiene inositol y excipientes, o inositol, excipientes y al menos un principio activo adicional, tal como ácido fólico, polifenoles de cocoa, genisteína, l-arginina, vitamina e, selenio, n-acetilcisteína y melatonina; útil para el tratamiento del ovario poliquístico, resistencia a la insulina y otros |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20140010870A1 (es) |
| EP (2) | EP3178474B1 (es) |
| CL (1) | CL2013002700A1 (es) |
| CY (2) | CY1122980T1 (es) |
| DK (2) | DK2502622T3 (es) |
| EA (1) | EA026746B1 (es) |
| ES (2) | ES2798267T3 (es) |
| HR (2) | HRP20200792T1 (es) |
| HU (2) | HUE049942T2 (es) |
| IL (1) | IL228465B (es) |
| IT (1) | ITMI20110445A1 (es) |
| LT (2) | LT3178474T (es) |
| MA (1) | MA35043B1 (es) |
| ME (1) | ME03750B (es) |
| MX (1) | MX2013010812A (es) |
| PE (1) | PE20141011A1 (es) |
| PL (2) | PL2502622T3 (es) |
| PT (2) | PT3178474T (es) |
| RS (2) | RS60377B1 (es) |
| SM (2) | SMT202000288T1 (es) |
| TN (1) | TN2013000373A1 (es) |
| UA (1) | UA115425C2 (es) |
| WO (1) | WO2012126931A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITUA20163025A1 (it) | 2016-04-29 | 2017-10-29 | Sochim Int S P A | Composizione per il trattamento della sindrome dell’ovaio policistico |
| JP6838146B2 (ja) * | 2016-10-06 | 2021-03-03 | ディーワイ ナチュラル カンパニー リミテッド | ピニトール、ｄ−カイロ−イノシトール、又はこれらの類似化合物を有効成分として含む、女性の更年期症状の改善、予防、又は治療用の組成物 |
| US11898184B2 (en) | 2017-09-07 | 2024-02-13 | Sweet Sense Inc. | Low glycemic sugar composition |
| CA3083301C (en) * | 2017-11-23 | 2024-05-21 | Biosearch, S.A. | Method for increasing embryo implantation rate in a female subject suffering polycystic ovary syndrome |
| EP3840592A1 (en) * | 2018-08-22 | 2021-06-30 | Société des Produits Nestlé S.A. | Composition comprising isomers of inositol and its use |
| CN114390923A (zh) * | 2019-08-30 | 2022-04-22 | 雀巢产品有限公司 | 鲨肌醇和β细胞介导的疾病 |
| US20220370378A1 (en) * | 2019-09-24 | 2022-11-24 | Societe Des Produits Nestle S.A. | Scyllo-inositol and its use as insulin sensitizer |
| RU2757220C1 (ru) * | 2020-06-03 | 2021-10-12 | Общество с ограниченной ответственностью "ОКТАВА ХОЛДИНГ" | Фармацевтическая композиция для профилактики и лечения синдрома поликистозных яичников |
| RU2771426C1 (ru) * | 2021-05-03 | 2022-05-04 | Румиса Рамзановна Бериханова | Способ коррекции дислипидемии у женщин с метаболическим синдромом в периоде менопаузального перехода |
| IT202300017805A1 (it) * | 2023-08-30 | 2025-03-02 | Idi Integratori Dietetici Italiani S R L | Nuova composizione comprendente teupolioside e inositolo |
| WO2026013420A1 (en) | 2024-07-10 | 2026-01-15 | Ioulia Tseti | Compositions for supporting women with gynaecological syndromes |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
| AU647735B2 (en) * | 1989-03-08 | 1994-03-31 | University Of Virginia Alumni Patents Foundation, The | Dietary supplement for insulin-resistant diabetics |
| TW282398B (es) * | 1993-12-22 | 1996-08-01 | Bristol Myers Squibb Co | |
| BR0010014A (pt) * | 1999-04-27 | 2002-01-15 | Insmed Pharm Inc | Composição farmacêutica compreendendo um inositol e um ìon de metal para melhorar sensibilidade à insulina e metabolismo de glucose |
| IL152360A0 (en) * | 2000-04-19 | 2003-05-29 | Genentech Inc | Sustained release formulations |
| TWI309984B (en) * | 2004-07-30 | 2009-05-21 | Wakunaga Pharma Co Ltd | Composition for capsule coating, capsule coating, and capsule agent |
| JP5088873B2 (ja) * | 2005-07-04 | 2012-12-05 | 国立大学法人 東京医科歯科大学 | Ｌ−アルギニン含有医薬組成物及び飲食品用組成物 |
| US20070243211A1 (en) * | 2005-11-07 | 2007-10-18 | Jaffe Russell M | Compositions for regulating metabolic disorders and methods of use thereof |
| US20070104801A1 (en) * | 2005-11-07 | 2007-05-10 | Ivf Online Llc | Fertility and anti-aging supplement for the fertility health of females and males |
| ITRM20070341A1 (it) * | 2007-06-20 | 2008-12-21 | Lo Li Pharma Srl | Formulazione integrativa inofolic finalizzata al controllo dell'induzione dell'ovulazione in programmi di procreazione medicalmente assistita |
| WO2011112167A1 (en) * | 2009-03-13 | 2011-09-15 | Reset Therapeutics, Inc. | Compositions and methods for diabetes treatment |
| EA201201202A1 (ru) * | 2010-03-01 | 2013-04-30 | Рациофарм Гмбх | Пероральная фармацевтическая композиция, содержащая этексилат дабигатрана |
-
2011
- 2011-03-22 IT IT000445A patent/ITMI20110445A1/it unknown
-
2012
- 2012-03-21 PE PE2013002088A patent/PE20141011A1/es not_active Application Discontinuation
- 2012-03-21 EA EA201301061A patent/EA026746B1/ru not_active IP Right Cessation
- 2012-03-21 UA UAA201312411A patent/UA115425C2/uk unknown
- 2012-03-21 US US14/006,582 patent/US20140010870A1/en not_active Abandoned
- 2012-03-21 MA MA36334A patent/MA35043B1/fr unknown
- 2012-03-21 WO PCT/EP2012/054960 patent/WO2012126931A1/en not_active Ceased
- 2012-03-21 MX MX2013010812A patent/MX2013010812A/es active IP Right Grant
- 2012-03-22 HU HUE16202982A patent/HUE049942T2/hu unknown
- 2012-03-22 SM SM20200288T patent/SMT202000288T1/it unknown
- 2012-03-22 SM SM20200364T patent/SMT202000364T1/it unknown
- 2012-03-22 DK DK12160674.3T patent/DK2502622T3/da active
- 2012-03-22 DK DK16202982.1T patent/DK3178474T3/da active
- 2012-03-22 ES ES16202982T patent/ES2798267T3/es active Active
- 2012-03-22 LT LTEP16202982.1T patent/LT3178474T/lt unknown
- 2012-03-22 HU HUE12160674A patent/HUE051001T2/hu unknown
- 2012-03-22 LT LTEP12160674.3T patent/LT2502622T/lt unknown
- 2012-03-22 ES ES12160674T patent/ES2806937T3/es active Active
- 2012-03-22 EP EP16202982.1A patent/EP3178474B1/en active Active
- 2012-03-22 PT PT162029821T patent/PT3178474T/pt unknown
- 2012-03-22 PT PT121606743T patent/PT2502622T/pt unknown
- 2012-03-22 RS RS20200667A patent/RS60377B1/sr unknown
- 2012-03-22 EP EP12160674.3A patent/EP2502622B1/en active Active
- 2012-03-22 RS RS20200966A patent/RS60650B1/sr unknown
- 2012-03-22 PL PL12160674T patent/PL2502622T3/pl unknown
- 2012-03-22 ME MEP-2020-118A patent/ME03750B/me unknown
- 2012-03-22 PL PL16202982T patent/PL3178474T3/pl unknown
-
2013
- 2013-09-16 IL IL228465A patent/IL228465B/en active IP Right Grant
- 2013-09-20 TN TNP2013000373A patent/TN2013000373A1/fr unknown
- 2013-09-23 CL CL2013002700A patent/CL2013002700A1/es unknown
-
2020
- 2020-05-15 HR HRP20200792TT patent/HRP20200792T1/hr unknown
- 2020-06-02 CY CY20201100518T patent/CY1122980T1/el unknown
- 2020-07-02 HR HRP20201048TT patent/HRP20201048T1/hr unknown
- 2020-07-20 CY CY20201100657T patent/CY1123134T1/el unknown
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