PE20061136A1 - Sistema de capsulas blandas que no son de gelatina - Google Patents
Sistema de capsulas blandas que no son de gelatinaInfo
- Publication number
- PE20061136A1 PE20061136A1 PE2005001306A PE2005001306A PE20061136A1 PE 20061136 A1 PE20061136 A1 PE 20061136A1 PE 2005001306 A PE2005001306 A PE 2005001306A PE 2005001306 A PE2005001306 A PE 2005001306A PE 20061136 A1 PE20061136 A1 PE 20061136A1
- Authority
- PE
- Peru
- Prior art keywords
- starch
- hydroxypropylate
- carragenin
- gelatine capsules
- encapsulation
- Prior art date
Links
- 229920000159 gelatin Polymers 0.000 title abstract 3
- 239000001828 Gelatine Substances 0.000 title abstract 2
- 239000002775 capsule Substances 0.000 title abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 2
- 229920002261 Corn starch Polymers 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 2
- 239000008120 corn starch Substances 0.000 abstract 2
- 238000005538 encapsulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008107 starch Substances 0.000 abstract 2
- 235000019698 starch Nutrition 0.000 abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 240000003183 Manihot esculenta Species 0.000 abstract 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 abstract 1
- 229920000881 Modified starch Polymers 0.000 abstract 1
- 239000004368 Modified starch Substances 0.000 abstract 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000019426 modified starch Nutrition 0.000 abstract 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 abstract 1
- 229960002009 naproxen Drugs 0.000 abstract 1
- 229960005489 paracetamol Drugs 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 abstract 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 239000007901 soft capsule Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A UN SISTEMA DE CAPSULA BLANDA QUE NO SON DE GELATINA QUE COMPRENDE: A) UNA ENVOLTURA QUE COMPRENDE i) UN ALMIDON MODIFICADO TAL COMO ALMIDON DE TAPIOCA HIDROXIPROPILADO, ALMIDON DE MAIZ HIDROXIPROPILADO, ENTRE OTROS, QUE TIENE UNA TEMPERATURA DE HIDRATACION INFERIOR A 90ºC, E ii) UNA CARRAGENINA GELIFICANTE TAL COMO IOTA-CARRAGENINA, KAPPA-CARRAGENINA O UNA MEZCLA DE ESTOS; LA RELACION PESO/PESO ENTRE EL ALMIDON Y LA CARRAGENINA ES ENTRE 1,5:1 Y 5:1, ADEMAS LA ENVOLTURA COMPRENDE AGUA, PLASTIFICANTE Y UN AMORTIGUADOR; Y B) UN RELLENO QUE TIENE UN pH MAYOR DE 7,5 QUE COMPRENDE i) UN PRINCIPIO ACTIVO DISUELTO O DISPERSO TAL COMO IBUPROFENO, NAPROXENO, ACETAMINOFEN, CLORHIDRATO DE PSEUDOEFEDRINA, ENTRE OTROS, ii) UN AGENTE ALCALINO CAPAZ DE NEUTRALIZAR HASTA EL 80% DEL PRINCIPIO ACTIVO ACIDO. DICHA COMPOSICION PERMITE LA ENCAPSULACION DE PRINCIPIOS ACTIVOS PREVIAMENTE CONSIDERADOS NO ADECUADOS PARA LA ENCAPSULACION EN CAPSULAS DE GELATINA TRADICIONAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/984,205 US8231896B2 (en) | 2004-11-08 | 2004-11-08 | Non-gelatin soft capsule system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061136A1 true PE20061136A1 (es) | 2006-10-27 |
Family
ID=36316590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001306A PE20061136A1 (es) | 2004-11-08 | 2005-11-08 | Sistema de capsulas blandas que no son de gelatina |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8231896B2 (es) |
| EP (2) | EP2289496B1 (es) |
| JP (1) | JP5192816B2 (es) |
| AR (1) | AR051237A1 (es) |
| AT (1) | ATE536866T1 (es) |
| AU (1) | AU2005305232B2 (es) |
| BR (1) | BRPI0517674B8 (es) |
| CA (1) | CA2585721C (es) |
| CY (1) | CY1112518T1 (es) |
| DK (1) | DK1809261T3 (es) |
| ES (2) | ES2379970T3 (es) |
| MX (1) | MX2007005403A (es) |
| PE (1) | PE20061136A1 (es) |
| PL (1) | PL1809261T3 (es) |
| PT (1) | PT1809261E (es) |
| SI (1) | SI1809261T1 (es) |
| TW (1) | TWI405592B (es) |
| UY (1) | UY29200A1 (es) |
| WO (1) | WO2006052452A1 (es) |
Families Citing this family (51)
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|---|---|---|---|---|
| US8802139B2 (en) * | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
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| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| HUE056937T2 (hu) | 2006-02-03 | 2022-04-28 | Opko Renal Llc | A D-vitamin elégtelenség és hiány kezelése 25-hidroxivitamin D2-vel és 25-hidroxivitamin D3-mal |
| CN104825397A (zh) * | 2006-04-03 | 2015-08-12 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| LT2679228T (lt) | 2006-06-21 | 2018-05-10 | Opko Ireland Global Holdings, Ltd. | Terapija naudojant vitamino d atstatymo agentą ir vitamino d hormoninį pakaitinį agentą |
| JP5021263B2 (ja) * | 2006-10-02 | 2012-09-05 | 中日本カプセル 株式会社 | 皮膜用組成物 |
| ES2401205T3 (es) | 2007-04-25 | 2013-04-17 | Cytochroma Inc. | Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| EP2148683A4 (en) | 2007-04-25 | 2012-09-12 | Proventiv Therapeutics Llc | SAFE AND EFFECTIVE METHOD OF TREATING AND PREVENTING SECONDARY HYPERPARATHYROIDIA IN CHRONIC RENAL DISEASES |
| US20090004231A1 (en) * | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
| US20090155355A1 (en) * | 2007-12-12 | 2009-06-18 | Multi Formulations Ltd. | Particles in a capsule |
| GB0801643D0 (en) * | 2008-01-29 | 2008-03-05 | Probio Nutraceuticals As | Product |
| US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
| BR112012005453B1 (pt) | 2009-09-10 | 2019-09-24 | DuPont Nutrition USA, Inc. | Cápsula sem costura, e, método para preparar uma cápsula de alginato sem costura |
| EP3636280B1 (en) | 2010-03-29 | 2025-05-14 | EirGen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| BR112013002721B8 (pt) * | 2010-08-04 | 2021-05-25 | Scherer Technologies Llc R P | composição formadora de filme para cápsulas moles, cápsulas moles e seu invólucro |
| KR101294614B1 (ko) | 2012-03-16 | 2013-08-08 | 주식회사 서흥캅셀 | 타피오카 변성전분을 주기재로 사용한 연질 캡슐 피막 조성물 |
| WO2012144789A2 (ko) * | 2011-04-20 | 2012-10-26 | 주식회사 서흥캅셀 | 붕해도 및 피막 경도를 개선한 비동물성 연질 캡슐 피막 조성물 |
| KR101178842B1 (ko) * | 2011-04-20 | 2012-09-03 | 주식회사 서흥캅셀 | 붕해도 및 피막 경도를 개선한 비동물성 연질 캡슐 피막 조성물 |
| KR101411364B1 (ko) * | 2012-03-16 | 2014-06-30 | 주식회사 서흥 | 전분을 주기재로 사용한 연질 캡슐 피막 조성물 |
| CA2905367A1 (en) | 2013-03-15 | 2014-09-25 | Banner Life Sciences Llc | Non-gelatin enteric soft capsules |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| KR101445334B1 (ko) * | 2013-06-05 | 2014-10-01 | 코스맥스바이오 주식회사 | 화학적 금속염을 포함하지 않는 식물성 연질캡슐조성물 |
| JP5769760B2 (ja) | 2013-06-25 | 2015-08-26 | アール．ピー． シェーラー テクノロジーズ エルエルシー | ソフトカプセル用シェル形成組成物及びソフトカプセル |
| WO2015003109A1 (en) * | 2013-07-03 | 2015-01-08 | R.P. Scherer Technologies, Llc | Capsule formulation comprising fexofenadine |
| WO2015059864A1 (ja) * | 2013-10-25 | 2015-04-30 | コニカミノルタ株式会社 | 粒子状肥料およびその製造方法 |
| CN103495176B (zh) * | 2013-10-26 | 2015-01-28 | 中山市凯博思淀粉材料科技有限公司 | 一种共混挤出法制备淀粉基软胶囊的方法 |
| CN103520133B (zh) * | 2013-10-26 | 2015-02-04 | 中山市凯博思淀粉材料科技有限公司 | 一种淀粉基软胶囊的制备方法 |
| CN103550065B (zh) * | 2013-10-26 | 2015-01-28 | 中山市凯博思淀粉材料科技有限公司 | 一种复合挤出法生产淀粉基软胶囊的方法 |
| CN103893771B (zh) * | 2014-04-21 | 2015-08-26 | 湖南尔康制药股份有限公司 | 一种用于生产淀粉材料软胶囊的成膜组合物及其制备方法 |
| CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN104337793A (zh) * | 2014-10-16 | 2015-02-11 | 浙江春宝胶囊有限公司 | 一种非明胶软胶囊壳的配方 |
| AU2016361585A1 (en) * | 2015-11-23 | 2018-07-12 | Undoo, LLC | Composition of olivetol and method of use reduce or inhibit the effects of tetrahydrocannabinol in the human body |
| JP6926453B2 (ja) * | 2015-12-03 | 2021-08-25 | 大正製薬株式会社 | カプセル組成物 |
| SG10201913863TA (en) | 2016-03-28 | 2020-03-30 | Opko Ireland Global Holdings Limited | Methods of vitamin d treatment |
| KR102384266B1 (ko) * | 2016-05-25 | 2022-04-06 | 티에스아이 그룹 리미티드 | 연질 겔 캡슐에서 베타-하이드록시이소발레르산 제형의 안정화 |
| EP3589280B1 (en) | 2017-03-03 | 2024-02-07 | Inspirna, Inc. | Formulations with improved stability |
| US10711119B2 (en) | 2018-01-10 | 2020-07-14 | Cp Kelco Aps | Carrageenan-based compositions for films and capsules |
| BR112022001165A2 (pt) * | 2019-07-23 | 2022-05-17 | Scherer Technologies Llc R P | Formulações de cápsula de casca macia e métodos de preparação e uso das mesmas |
| MX2023011596A (es) * | 2021-04-01 | 2023-10-10 | Scherer Technologies Llc R P | Fosfolipidos como agentes quelantes de aniones en formulaciones farmaceuticas. |
| KR20240037990A (ko) * | 2021-07-06 | 2024-03-22 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 소프트겔 캡슐 |
| AU2021107198A4 (en) * | 2021-08-24 | 2021-12-09 | Blackmores Ltd | A softgel capsule composition, and a process for producing a softgel capsule therefrom |
| EP4176724A1 (en) | 2021-11-09 | 2023-05-10 | Universität Hohenheim | Use of an oleogel as a layer or coating |
| TW202408464A (zh) * | 2022-08-12 | 2024-03-01 | 美商Ｒ Ｐ 先靈爾科技公司 | 快速溶解軟凝膠膠囊 |
| WO2025042689A1 (en) * | 2023-08-18 | 2025-02-27 | R.P. Scherer Technologies, Llc | Softgel capsule including a non-steroidal anti-inflammatory drug and acetaminophen |
| WO2025064293A1 (en) * | 2023-09-18 | 2025-03-27 | R.P. Scherer Technologies, Llc | Fast dissolving softgel capsules including ibuprofen |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118040A (en) | 1982-02-15 | 1983-10-26 | Hoechst Uk Ltd | Oral anti-diabetic preparation |
| GB8305693D0 (en) | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
| DE3307353C2 (de) | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung |
| US5071643A (en) | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
| JPS63164858A (ja) * | 1986-12-27 | 1988-07-08 | Unie Koroido Kk | 軟カプセルの外皮 |
| JPH0525037A (ja) | 1991-07-01 | 1993-02-02 | Upjohn Co:The | 経口投与酵素感受性腸溶製剤 |
| GB9226238D0 (en) | 1992-12-16 | 1993-02-10 | Scherer Ltd R P | Encapsulation apparatus and process |
| US5376688A (en) | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
| US5505961A (en) | 1993-08-05 | 1996-04-09 | R. P. Scherer Corporation | Gelatin capsules containing a highly concentrated acetaminophen solution |
| GB9705770D0 (en) | 1997-03-20 | 1997-05-07 | Scherer Corp R P | Gelatin encapsulation techniques |
| US20030104048A1 (en) | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
| US6340473B1 (en) | 1999-07-07 | 2002-01-22 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| US6387400B1 (en) | 2000-08-29 | 2002-05-14 | R.P. Scherer Technologies, Inc. | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
| US6884060B2 (en) | 2001-11-02 | 2005-04-26 | R.P. Scherer Technologies, Inc. | Apparatus for manufacturing encapsulated products |
| US7887838B2 (en) | 2002-01-18 | 2011-02-15 | Banner Pharmacaps, Inc. | Non-gelatin film and method and apparatus for producing same |
| CN100344328C (zh) * | 2002-09-13 | 2007-10-24 | 锡德克斯公司 | 以衍生环糊精稳定化的含有水性填充组合物的胶囊 |
| JP2004250369A (ja) * | 2003-02-19 | 2004-09-09 | Fuji Capsule Kk | 軟カプセル剤皮膜組成物 |
| US20050137262A1 (en) | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
-
2004
- 2004-11-08 US US10/984,205 patent/US8231896B2/en active Active
-
2005
- 2005-10-26 ES ES05823349T patent/ES2379970T3/es not_active Expired - Lifetime
- 2005-10-26 EP EP10194764.6A patent/EP2289496B1/en not_active Expired - Lifetime
- 2005-10-26 ES ES10194764.6T patent/ES2603225T3/es not_active Expired - Lifetime
- 2005-10-26 PT PT05823349T patent/PT1809261E/pt unknown
- 2005-10-26 PL PL05823349T patent/PL1809261T3/pl unknown
- 2005-10-26 WO PCT/US2005/038532 patent/WO2006052452A1/en not_active Ceased
- 2005-10-26 SI SI200531747T patent/SI1809261T1/sl unknown
- 2005-10-26 AT AT05823349T patent/ATE536866T1/de active
- 2005-10-26 DK DK05823349.5T patent/DK1809261T3/da active
- 2005-10-26 MX MX2007005403A patent/MX2007005403A/es active IP Right Grant
- 2005-10-26 JP JP2007540346A patent/JP5192816B2/ja not_active Expired - Lifetime
- 2005-10-26 AU AU2005305232A patent/AU2005305232B2/en not_active Expired
- 2005-10-26 BR BRPI0517674A patent/BRPI0517674B8/pt active IP Right Grant
- 2005-10-26 CA CA2585721A patent/CA2585721C/en not_active Expired - Lifetime
- 2005-10-26 EP EP05823349A patent/EP1809261B1/en not_active Expired - Lifetime
- 2005-11-08 TW TW094139199A patent/TWI405592B/zh not_active IP Right Cessation
- 2005-11-08 UY UY29200A patent/UY29200A1/es not_active IP Right Cessation
- 2005-11-08 AR ARP050104668A patent/AR051237A1/es not_active Application Discontinuation
- 2005-11-08 PE PE2005001306A patent/PE20061136A1/es not_active Application Discontinuation
-
2012
- 2012-03-14 CY CY20121100264T patent/CY1112518T1/el unknown
- 2012-07-06 US US13/543,244 patent/US8377470B2/en not_active Expired - Lifetime
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