PE20080279A1 - DERIVADOS DE PIRAZOL[4,3-d]TIAZOL COMO INHIBIDORES DE LA PROTEINA QUINASA AURORA 1 Y 2 - Google Patents
DERIVADOS DE PIRAZOL[4,3-d]TIAZOL COMO INHIBIDORES DE LA PROTEINA QUINASA AURORA 1 Y 2Info
- Publication number
- PE20080279A1 PE20080279A1 PE2007000952A PE2007000952A PE20080279A1 PE 20080279 A1 PE20080279 A1 PE 20080279A1 PE 2007000952 A PE2007000952 A PE 2007000952A PE 2007000952 A PE2007000952 A PE 2007000952A PE 20080279 A1 PE20080279 A1 PE 20080279A1
- Authority
- PE
- Peru
- Prior art keywords
- thiazol
- methyl
- pirazol
- inhibitors
- protein kinase
- Prior art date
Links
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title abstract 5
- 108090000461 Aurora Kinase A Proteins 0.000 title abstract 2
- 102100032311 Aurora kinase A Human genes 0.000 title abstract 2
- 102100032306 Aurora kinase B Human genes 0.000 title abstract 2
- 108090000749 Aurora kinase B Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 1-METHYL-1-PHENYL-ETHYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical compound NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 abstract 1
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL[4,3-d]TIAZOL DE FORMULA (I) DONDE R1 ES NHR5, EN DONDE R5 ES H O COR6; R6 ES H, ALQUILO(C1-C20), ALQUENILO(C2-C20), ALQUINILO(C2-C20), CICLOALQUILO(C3-C8), ENTRE OTROS; R2 ES HALOGENO, ALQUILO(C1-C20), ALCOXI(C1-C20), OH, CN, ENTRE OTROS; R3 Y R4 SON CADA UNO ALQUILO(C1-C20) OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALCOXI(C1-C20), OH, NO2, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: N-(1-METIL-1-FENIL-ETIL)-(3-AMINO-1H-PIRAZOL[4,3-d]TIAZOL)-5-CARBOXAMIDA, N-(1-METIL-1-FENIL-ETIL)-3-[4-(4-METIL-PIPERAZIN-1-IL)-BENZOILAMINO]-1H-PIRAZOL[4,3-d]TIAZOL)-5-CARBOXAMIDA, N-(1-METIL-1-FENIL-ETIL)-3-(4-MORFOLIN-4-IL-BENZOILAMINO)-1H-PIRAZOL[4,3-d]TIAZOL)-5-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA AURORA 1 Y 2 SIENDO UTILES EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0607128A FR2904626B1 (fr) | 2006-08-03 | 2006-08-03 | Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080279A1 true PE20080279A1 (es) | 2008-05-13 |
Family
ID=37877046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000952A PE20080279A1 (es) | 2006-08-03 | 2007-07-23 | DERIVADOS DE PIRAZOL[4,3-d]TIAZOL COMO INHIBIDORES DE LA PROTEINA QUINASA AURORA 1 Y 2 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7772261B2 (es) |
| EP (1) | EP2051985B1 (es) |
| JP (1) | JP5400613B2 (es) |
| AR (1) | AR062163A1 (es) |
| FR (1) | FR2904626B1 (es) |
| PE (1) | PE20080279A1 (es) |
| TW (1) | TW200813072A (es) |
| UY (1) | UY30523A1 (es) |
| WO (1) | WO2008015340A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703811B2 (en) | 2008-05-07 | 2014-04-22 | Genzyme Corporation | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase |
| WO2010070060A1 (en) | 2008-12-19 | 2010-06-24 | Nerviano Medical Sciences S.R.L. | Bicyclic pyrazoles as protein kinase inhibitors |
| JP5868957B2 (ja) | 2010-05-05 | 2016-02-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺虫剤としてのチアゾール誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2411188A1 (fr) | 1977-12-12 | 1979-07-06 | Parcor | N-(thenoyl-2) et n-(thenoyl-3) glycinates de magnesium ayant notamment des proprietes antispasmophitiques |
| JPH09501171A (ja) | 1993-08-06 | 1997-02-04 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄ受容体アンタゴニストとしてのアミド誘導体 |
| IL164209A0 (en) | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
| BR0312961A (pt) | 2002-07-25 | 2005-06-14 | Pharmacia Italia Spa | Derivados condensados heterociclicos de pirazol como inibidores de cinase |
| US20050026984A1 (en) * | 2003-07-29 | 2005-02-03 | Aventis Pharma S.A. | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products |
| US7473783B2 (en) | 2003-12-17 | 2009-01-06 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo protein kinase modulators |
| TW200526204A (en) * | 2004-02-03 | 2005-08-16 | Pharmacia Italia Spa | 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors |
| US7300949B2 (en) * | 2004-03-31 | 2007-11-27 | Lexicon Pharmaceuticals, Inc. | Thiazolopyrazoles and methods of their use |
| EP1751136B1 (en) | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| JP2009515998A (ja) | 2005-11-16 | 2009-04-16 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | ピラゾロチアゾールタンパク質キナーゼモジュレータ |
-
2006
- 2006-08-03 FR FR0607128A patent/FR2904626B1/fr active Active
-
2007
- 2007-07-13 TW TW096125712A patent/TW200813072A/zh unknown
- 2007-07-23 PE PE2007000952A patent/PE20080279A1/es not_active Application Discontinuation
- 2007-07-31 EP EP07823379.8A patent/EP2051985B1/fr active Active
- 2007-07-31 WO PCT/FR2007/001326 patent/WO2008015340A2/fr not_active Ceased
- 2007-07-31 JP JP2009522305A patent/JP5400613B2/ja not_active Expired - Fee Related
- 2007-08-01 AR ARP070103380A patent/AR062163A1/es unknown
- 2007-08-03 UY UY30523A patent/UY30523A1/es not_active Application Discontinuation
-
2009
- 2009-01-21 US US12/356,740 patent/US7772261B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009545576A (ja) | 2009-12-24 |
| UY30523A1 (es) | 2008-02-29 |
| WO2008015340A3 (fr) | 2009-04-16 |
| FR2904626A1 (fr) | 2008-02-08 |
| EP2051985B1 (fr) | 2014-04-16 |
| WO2008015340A2 (fr) | 2008-02-07 |
| US20090176779A1 (en) | 2009-07-09 |
| TW200813072A (en) | 2008-03-16 |
| EP2051985A2 (fr) | 2009-04-29 |
| JP5400613B2 (ja) | 2014-01-29 |
| US7772261B2 (en) | 2010-08-10 |
| AR062163A1 (es) | 2008-10-22 |
| FR2904626B1 (fr) | 2008-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |