PE20080183A1 - Terapias de combinacion de tra - Google Patents
Terapias de combinacion de traInfo
- Publication number
- PE20080183A1 PE20080183A1 PE2007000416A PE2007000416A PE20080183A1 PE 20080183 A1 PE20080183 A1 PE 20080183A1 PE 2007000416 A PE2007000416 A PE 2007000416A PE 2007000416 A PE2007000416 A PE 2007000416A PE 20080183 A1 PE20080183 A1 PE 20080183A1
- Authority
- PE
- Peru
- Prior art keywords
- refers
- tra
- receptor antagonist
- combination therapies
- receptor
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 239000002464 receptor antagonist Substances 0.000 abstract 2
- 229940044551 receptor antagonist Drugs 0.000 abstract 2
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 abstract 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 229960000528 amlodipine Drugs 0.000 abstract 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 229940090880 ardeparin Drugs 0.000 abstract 1
- 229960002274 atenolol Drugs 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 229960004969 dalteparin Drugs 0.000 abstract 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 1
- 229960004166 diltiazem Drugs 0.000 abstract 1
- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 abstract 1
- 229960002994 dofetilide Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229960000610 enoxaparin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 abstract 1
- 230000009863 secondary prevention Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 229960001722 verapamil Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN ANTAGONISTA RECEPTOR DE TROMBINA Y UN AGENTE CARDIOVASCULAR SELECCIONADO DE BLOQUEDORES DE CANALES DE CALCIO TAL COMO AMLODIPINA, DILTIAZEM, VERAPAMIL, ENTRE OTROS, ESTATINAS TALES COMO FLUVASTATINA, LOVASTATINA, PRAVASTATINA, ENTRE OTROS, HEPARINAS DE BAJO PESO MOLECULAR SELECCIONADO DE DALTEPARINA, ARDEPARINA, ENOXAPARINA, ENTRE OTROS, ANTIARRITMICOS SELECCIONADOS DE DOFETILIDA, ATENOLOL, PROPANOLOL, ENTRE OTROS, BLOQUEDORES ADRENERGICOS, IECA, BLOQUEADOR DEL RECEPTOR ANGIOTENSINA II, ANTAGONISTA DE ENDOTELINA, ENTRE OTROS. UN ANTAGONISTA RECEPTOR DE TROMBINA ES A, B, C, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE SINDROMES CORONARIOS Y PREVENCION SECUNDARIA EN PACIENTES SUCEPTIBLES A EVENTOS CARDIOVASCULARES
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79046906P | 2006-04-06 | 2006-04-06 | |
| US80861106P | 2006-05-26 | 2006-05-26 | |
| US80978506P | 2006-05-31 | 2006-05-31 | |
| US83948406P | 2006-08-23 | 2006-08-23 | |
| US83947406P | 2006-08-23 | 2006-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080183A1 true PE20080183A1 (es) | 2008-03-10 |
Family
ID=38458156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000416A PE20080183A1 (es) | 2006-04-06 | 2007-04-04 | Terapias de combinacion de tra |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2001471A1 (es) |
| JP (1) | JP2009532487A (es) |
| AR (1) | AR060354A1 (es) |
| AU (1) | AU2007235353A1 (es) |
| BR (1) | BRPI0710840A2 (es) |
| CA (1) | CA2648613A1 (es) |
| MX (1) | MX2008012933A (es) |
| NO (1) | NO20084677L (es) |
| PE (1) | PE20080183A1 (es) |
| TW (1) | TW200812619A (es) |
| WO (1) | WO2007117621A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| CA2708418C (en) * | 2007-12-11 | 2013-11-12 | Bayer Schering Pharma Aktiengesellschaft | Oxazolidinones for the treatment and/or prophylaxis of heart failure |
| MX2010007527A (es) * | 2008-01-11 | 2010-10-05 | Eisai R&D Man Co Ltd | Composicion farmaceutica, uso del derivado 2-iminopirrolidina para la produccion de la composicion farmaceutica y kit para el tratamiento o mejora de enfermedaes cardiacas. |
| WO2009124103A2 (en) * | 2008-04-02 | 2009-10-08 | Schering Corporation | Combination therapies comprising par1 antagonists with par4 antagonists |
| WO2010144339A2 (en) * | 2009-06-08 | 2010-12-16 | Schering Corporation | A thrombin receptor antagonist and clopidogrel fixed dose tablet |
| US20130183392A1 (en) * | 2011-07-15 | 2013-07-18 | Steven Moore | Insect repellant and system |
| KR20140028971A (ko) * | 2012-08-31 | 2014-03-10 | 한미약품 주식회사 | 아토바스타틴, 이르베살탄 및 탄산마그네슘을 포함하는 이층정 복합제제 |
| CN105125504A (zh) * | 2015-09-17 | 2015-12-09 | 青岛华之草医药科技有限公司 | 一种降血脂药物匹伐他汀钙组合物颗粒剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| US7488742B2 (en) * | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
| ATE455774T1 (de) * | 2002-04-16 | 2010-02-15 | Schering Corp | Trizyklische thrombinrezeptorantagonisten |
| CA2567981C (en) * | 2004-05-28 | 2010-08-31 | Schering Corporation | Constrained himbacine analogs as thrombin receptor antagonists |
| RU2408594C2 (ru) * | 2004-10-08 | 2011-01-10 | Шеринг Корпорейшн | Антагонисты рецептора тромбина |
| US7776889B2 (en) * | 2005-03-31 | 2010-08-17 | Schering Corporation | Spirocyclic thrombin receptor antagonists |
| JP2009521472A (ja) * | 2005-12-22 | 2009-06-04 | シェーリング コーポレイション | 心肺手術の合併症の予防としてのトロンビンレセプターアンタゴニスト |
| AR058400A1 (es) * | 2005-12-22 | 2008-01-30 | Schering Corp | Derivados de oxazoloisoquinolina como antagonistas del receptor de trombina |
-
2007
- 2007-04-04 PE PE2007000416A patent/PE20080183A1/es not_active Application Discontinuation
- 2007-04-04 AR ARP070101439A patent/AR060354A1/es not_active Application Discontinuation
- 2007-04-04 TW TW096112178A patent/TW200812619A/zh unknown
- 2007-04-05 MX MX2008012933A patent/MX2008012933A/es unknown
- 2007-04-05 AU AU2007235353A patent/AU2007235353A1/en not_active Abandoned
- 2007-04-05 CA CA002648613A patent/CA2648613A1/en not_active Abandoned
- 2007-04-05 EP EP07755024A patent/EP2001471A1/en not_active Withdrawn
- 2007-04-05 JP JP2009504321A patent/JP2009532487A/ja not_active Withdrawn
- 2007-04-05 BR BRPI0710840-0A patent/BRPI0710840A2/pt not_active IP Right Cessation
- 2007-04-05 WO PCT/US2007/008612 patent/WO2007117621A1/en not_active Ceased
-
2008
- 2008-11-05 NO NO20084677A patent/NO20084677L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0710840A2 (pt) | 2011-08-23 |
| EP2001471A1 (en) | 2008-12-17 |
| MX2008012933A (es) | 2008-10-15 |
| WO2007117621A1 (en) | 2007-10-18 |
| TW200812619A (en) | 2008-03-16 |
| CA2648613A1 (en) | 2007-10-18 |
| NO20084677L (no) | 2008-11-05 |
| AR060354A1 (es) | 2008-06-11 |
| JP2009532487A (ja) | 2009-09-10 |
| AU2007235353A1 (en) | 2007-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |