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PE20080993A1 - Compuestos ciclicos fusionados como moduladores del receptor gpr40 - Google Patents

Compuestos ciclicos fusionados como moduladores del receptor gpr40

Info

Publication number
PE20080993A1
PE20080993A1 PE2007000827A PE2007000827A PE20080993A1 PE 20080993 A1 PE20080993 A1 PE 20080993A1 PE 2007000827 A PE2007000827 A PE 2007000827A PE 2007000827 A PE2007000827 A PE 2007000827A PE 20080993 A1 PE20080993 A1 PE 20080993A1
Authority
PE
Peru
Prior art keywords
hydroxy
gpr40
modulators
receiver
metoxy
Prior art date
Application number
PE2007000827A
Other languages
English (en)
Inventor
Tsuneo Yasuma
Nobuyuki Negoro
Masayuki Yamashita
Misahiro Itou
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20080993A1 publication Critical patent/PE20080993A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE R1 ES R6-SO2- O 1,1 DIOXIDOTETRAHIDROTIOPIRANILO OPCIONALMENTE SUSTITUIDO; X ES UN ENLACE O UN HIDROCARBONADO DIVALENTE; R2 Y R3 SON INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS; R4 Y R5 SON INDEPENDIENTEMENTE ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HIDROXI; A ES UN ANILLO BENCENICO, UN HIDROCARBONADO, AMINO O HIDROXI OPCIONALMENTE SUSTITUIDOS; B ES UN ANILLO DE 5 A 7 MIEMBROS; Y ES ENLACE O CH2; R ES HIDROXI SUSTITUIDO O NO. SON SELECCIONADOS: ACIDO[(3S)-6-({4'-[(4-HIDROXI-1,1-DIOXIDOTETRAHIDRO-2H-TIOPIRAN-4-IL)METOXI]-2',6'.DIMETILBIFENIL-3-IL}METOXI)-2,3-DIHIDRO-1-BENZOFURAN-3-IL]ACETICO, ACIDO [(3S)-6-({2',6'-DIMETIL-4'-[3-(METILSULFONIL)-PROPOXI]BIFENIL-3-IL}METOXI)-2,3-DIHIDRO-1-BENZOFURAN-3-IL]ACETICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON AGONISTAS DEL RECEPTOR GPR4O Y SON UTILES COMO SECRETAGOGO DE INSULINA Y EN EL TRATAMIENTO DE LA DIABETES Y SIMILARES
PE2007000827A 2006-06-27 2007-06-26 Compuestos ciclicos fusionados como moduladores del receptor gpr40 PE20080993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006177099 2006-06-27

Publications (1)

Publication Number Publication Date
PE20080993A1 true PE20080993A1 (es) 2008-10-06

Family

ID=38656568

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000827A PE20080993A1 (es) 2006-06-27 2007-06-26 Compuestos ciclicos fusionados como moduladores del receptor gpr40

Country Status (36)

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US (5) US7732626B2 (es)
EP (4) EP2248812B1 (es)
JP (3) JP4401428B2 (es)
KR (1) KR101058772B1 (es)
CN (4) CN103070854A (es)
AR (1) AR061644A1 (es)
AT (1) ATE543815T1 (es)
AU (1) AU2007265966B2 (es)
BR (1) BRPI0713378A8 (es)
CA (2) CA2838448A1 (es)
CL (1) CL2007001873A1 (es)
CO (1) CO6160234A2 (es)
CR (1) CR10564A (es)
CY (2) CY1112705T1 (es)
DK (2) DK2248812T5 (es)
ES (2) ES2450081T3 (es)
GE (1) GEP20115359B (es)
HR (2) HRP20120333T1 (es)
IL (1) IL195947A (es)
JO (1) JO2969B1 (es)
MA (1) MA30537B1 (es)
ME (1) ME00535B (es)
MX (1) MX2008016274A (es)
MY (1) MY154798A (es)
NO (1) NO20090235L (es)
NZ (1) NZ574038A (es)
PE (1) PE20080993A1 (es)
PL (2) PL2041123T3 (es)
PT (2) PT2041123E (es)
RS (2) RS52307B (es)
RU (1) RU2444521C2 (es)
SI (2) SI2041123T1 (es)
TW (1) TWI354668B (es)
UA (1) UA95296C2 (es)
WO (1) WO2008001931A2 (es)
ZA (1) ZA200900154B (es)

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