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PE20080704A1 - Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo - Google Patents

Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo

Info

Publication number
PE20080704A1
PE20080704A1 PE2007000614A PE2007000614A PE20080704A1 PE 20080704 A1 PE20080704 A1 PE 20080704A1 PE 2007000614 A PE2007000614 A PE 2007000614A PE 2007000614 A PE2007000614 A PE 2007000614A PE 20080704 A1 PE20080704 A1 PE 20080704A1
Authority
PE
Peru
Prior art keywords
alkyl
cyclopropyl
indolobenzazepine
fused
hepatitis
Prior art date
Application number
PE2007000614A
Other languages
English (en)
Inventor
Robert G Gentles
Piyasena Hewawasam
Min Ding
Carl P Bergstrom
Scott W Martin
Kap-Sun Yeung
Thomas W Hudyma
Xiaofan Zheng
John A Bender
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20080704A1 publication Critical patent/PE20080704A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS INDOLOBENZAZEPINA FUSIONADOS A CICLOPROPILO DE FORMULA (I), EN DONDE R1 ES CO2R5 O CONR6R7; R2 ES PIPERIDINILO O PIPERAZINILO SUSTITUIDO CON 3 SUSTUSTITUYENTES SELECCIONADOS DE ALQUILO, ALCOXIALQUILO, ENTRE OTROS; R3 ES H, HALO, ALQUILO, ALQUENILO, ALCOXI, ENTRE OTROS; R4 ES CICLOALQUILO; R5 ES H O ALQUILO; R6 ES H, ALQUILO, ALQUILO-SO2; CICLOALQUILO-SO2, (R7)(R8)NSO2 O (R9)SO2; R7 Y R8 SON INDEPENDIENTEMENTE H O ALQUILO. SON SELECCIONADOS: CICLOPROPIL[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA,1a-[[(3a,5a)-4-ACETIL-3,5-DIMETIL-1-PIPERAZINIL]CARBONIL]-8-CICLOHEXIL-N-[(DIMETILAMINO)SULFONIL]-1,1a,2,12b-TETRAHIDRO-11-METOXI, CICLOPROPIL[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA, 8-CICLOHEXIL-1,1a,2,12b-TETRAHIDRO-11-METOXI-N-(2-PROPILSULFONIL}-1a-[[(3R,5S)-3,4,5-TRIMETIL-1-PIPERAZINIL]CARBONIL], ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS PUEDE COMPRENDER OTRO AGENTE ANTI VHC. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE NS5B DEL VHC SIENDO UTILES EN EL TRATAMIENTO DE INFECCION DEL VHC
PE2007000614A 2006-05-22 2007-05-18 Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo PE20080704A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80236806P 2006-05-22 2006-05-22
US89425307P 2007-03-12 2007-03-12

Publications (1)

Publication Number Publication Date
PE20080704A1 true PE20080704A1 (es) 2008-06-13

Family

ID=38514150

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000614A PE20080704A1 (es) 2006-05-22 2007-05-18 Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo

Country Status (5)

Country Link
US (1) US7521441B2 (es)
AR (1) AR061053A1 (es)
PE (1) PE20080704A1 (es)
TW (1) TW200817403A (es)
WO (1) WO2007140109A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1688420A4 (en) * 2003-11-19 2008-10-22 Japan Tobacco Inc 5-5 LOW-CONDENSED HETEROCYCLIC COMPOUND AND THEIR USE AS HCV POLYMERASE INHIBITOR
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
US7521443B2 (en) * 2006-05-17 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7541351B2 (en) * 2007-01-11 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7541352B2 (en) * 2007-02-02 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7517872B2 (en) * 2007-02-22 2009-04-14 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7998951B2 (en) * 2007-03-05 2011-08-16 Bristol-Myers Squibb Company HCV NS5B inhibitors
US7541353B2 (en) * 2007-03-14 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7538102B2 (en) * 2007-03-14 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US7521444B2 (en) * 2007-03-14 2009-04-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7547690B2 (en) * 2007-03-14 2009-06-16 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US7538103B2 (en) * 2007-03-15 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
AU2008248116A1 (en) 2007-05-04 2008-11-13 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of HCV infection
US8143243B2 (en) * 2007-08-09 2012-03-27 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7642251B2 (en) * 2007-08-09 2010-01-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7652004B2 (en) * 2007-08-09 2010-01-26 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8129367B2 (en) * 2007-11-21 2012-03-06 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
PT2238142E (pt) 2007-12-24 2012-09-24 Janssen R & D Ireland Indoles macrocíclicos como inibidores do vírus da hepatite c
CN101977914A (zh) * 2008-03-27 2011-02-16 百时美施贵宝公司 用于治疗丙型肝炎的化合物
US8119628B2 (en) * 2008-03-27 2012-02-21 Bristol-Myers Squibb Company Pyrrolidine fused indolobenzadiazepine HCV NS5B inhibitors
MX2010010245A (es) * 2008-03-27 2010-10-05 Bristol Myers Squibb Co Inhibidores de ns5b de virus de la hepatitis c de indolobenzadiazepina fusionados a dioxolano y dioxolanona.
US8133884B2 (en) * 2008-05-06 2012-03-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US9127010B2 (en) 2010-06-24 2015-09-08 Janssen Sciences Ireland Uc Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
PE20140039A1 (es) 2010-12-30 2014-03-01 Enanta Pharm Inc Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina
CA2822556A1 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
JP2019524706A (ja) 2016-07-08 2019-09-05 ジェネンテック， インコーポレイテッド Ｍｕｃ１６陽性癌治療の応答性を評価するためのヒト精巣上体タンパク質４（ｈｅ４）の使用
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2322602T3 (es) 2004-02-24 2009-06-23 Japan Tobacco, Inc. Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc.
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
US7348425B2 (en) 2004-08-09 2008-03-25 Bristol-Myers Squibb Company Inhibitors of HCV replication
ATE384723T1 (de) 2004-10-13 2008-02-15 Merck Patent Gmbh Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs
US7662809B2 (en) 2004-10-26 2010-02-16 Istituto Di Richerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
US7399758B2 (en) 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7473688B2 (en) 2005-09-13 2009-01-06 Bristol-Myers Squibb Company Indolobenzazepine HCV NS5B inhibitors
US7456165B2 (en) 2006-02-08 2008-11-25 Bristol-Myers Squibb Company HCV NS5B inhibitors

Also Published As

Publication number Publication date
US20070270406A1 (en) 2007-11-22
TW200817403A (en) 2008-04-16
AR061053A1 (es) 2008-07-30
WO2007140109A1 (en) 2007-12-06
US7521441B2 (en) 2009-04-21

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