PE20071116A1 - Compuestos de heteroarilo biciclicos como inhibidores de pde10 - Google Patents
Compuestos de heteroarilo biciclicos como inhibidores de pde10Info
- Publication number
- PE20071116A1 PE20071116A1 PE2007000001A PE2007000001A PE20071116A1 PE 20071116 A1 PE20071116 A1 PE 20071116A1 PE 2007000001 A PE2007000001 A PE 2007000001A PE 2007000001 A PE2007000001 A PE 2007000001A PE 20071116 A1 PE20071116 A1 PE 20071116A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- bicycle
- heteroaryl
- benzoimidazole
- pyridin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- FGYADSCZTQOAFK-UHFFFAOYSA-N 1-methylbenzimidazole Chemical compound C1=CC=C2N(C)C=NC2=C1 FGYADSCZTQOAFK-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROARILO BICICLICO DE FORMULA (I), DONDE HET1 SE SELECCIONA DE HETEROARILO MONOCICLICO Y UN HETEROARILO BICICLICO, DONDE DICHO HET1 ESTA OPCIONALMENTE SUSTITUIDO CON POR LO MENOS UN R4; HET2 ES UN HETEROARILO MONOCICLICO OPCIONALMENTE SUSTITUIDO CON R5; HET3 ES UN HETEROARILO BICICLICO DE 8 O 9 MIEMBROS OPCIONALMENTE SUSTITUIDO CON R6; R1 ES HALOGENO, OH, CIANO, ALQUILO C1-C8, ENTRE OTROS; B1 Y B2 SON CARBONO O NITROGENO; B3 ES CARBONO; B4 ES NITROGENO; X Y X1 SON OXIGENO, AZUFRE O C(R2)2; R4 ES H, ALQUILO C1-C8, CIANO, OH, ENTRE OTROS; R5 ES HALOGENO, OH, ALQUENILO C2-C8, ENTRE OTROS; R6 ES ALQUILO C1-C8, ALQUENILO C2-C8, OH, ENTRE OTROS; R2 ES ALQUILO C1-C8, H, ALQUENILO C2-C8, ENTRE OTROS; p ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 1-METIL-2-[4-(4-PIRIDIN-4-IL-1H-PIRAZOL-3-IL)-FENOXIMETIL]-1H-BENZOIMIDAZOL, 2-[4-(1-ETIL-4-PIRIDIN-4-IL-1H-PIRAZOL-3-IL)-FENOXIMETIL]-1-METIL-1H-BENZOIMIDAZOL, 1-{3-[4-(1-METIL-1H-BENZOIMIDAZOL-2-IL-METOXI)-FENIL]-4-PIRIDIN-4-IL-PIRAZOL-1-IL}-PROPAN-2-OL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA (PDE), PREFERIBLEMENTE PDE-10 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS NEURODEGENERATIVOS, PSIQUIATRICOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75645006P | 2006-01-05 | 2006-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071116A1 true PE20071116A1 (es) | 2007-11-17 |
Family
ID=38131538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000001A PE20071116A1 (es) | 2006-01-05 | 2007-01-03 | Compuestos de heteroarilo biciclicos como inhibidores de pde10 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070155779A1 (es) |
| EP (1) | EP1979343A2 (es) |
| JP (1) | JP2009522346A (es) |
| AR (1) | AR058919A1 (es) |
| CA (1) | CA2636264A1 (es) |
| NL (1) | NL2000397C2 (es) |
| PE (1) | PE20071116A1 (es) |
| TW (1) | TW200736246A (es) |
| UY (1) | UY30080A1 (es) |
| WO (1) | WO2007077490A2 (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2650976A1 (en) * | 2006-05-02 | 2007-11-15 | Pfizer Products Inc. | Bicyclic heteroaryl compounds as pde10 inhibitors |
| PE20091953A1 (es) * | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| RU2506260C2 (ru) * | 2008-06-25 | 2014-02-10 | Энвиво Фармасьютикалз, Инк. | 1,2-дизамещенные гетероциклические соединения |
| KR20110031355A (ko) | 2008-06-25 | 2011-03-25 | 엔비보 파마슈티칼즈, 인코퍼레이티드 | １,２―이치환된 헤테로사이클릭 화합물 |
| US9061984B2 (en) * | 2008-08-15 | 2015-06-23 | University Of Louisville Research Foundation, Inc. | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases |
| TW201030001A (en) | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
| AU2009333214B2 (en) * | 2008-12-17 | 2013-09-26 | Amgen Inc. | Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors |
| HUE026238T2 (en) * | 2009-05-07 | 2016-06-28 | Forum Pharmaceuticals Inc | Phenoxymethyl heterocyclic compounds |
| BRPI1009637A2 (pt) | 2009-06-05 | 2019-04-30 | Cephalon, Inc | composto, composição e uso de um composto |
| WO2011053559A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Aryl aminopyridine pde10 inhibitors |
| AU2010311493B2 (en) * | 2009-10-30 | 2014-06-05 | Janssen Pharmaceutica Nv | Radiolabelled PDE10 ligands |
| TWI487705B (zh) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| US8969349B2 (en) | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
| TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
| JP5973990B2 (ja) * | 2011-03-16 | 2016-08-23 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| JP2014122161A (ja) * | 2011-03-31 | 2014-07-03 | Astellas Pharma Inc | ピラゾール化合物 |
| EP2714041B1 (en) | 2011-05-24 | 2016-10-19 | Merck Sharp & Dohme Corp. | Aryloxymethyl cyclopropane derivatives as pde10 inhibitors |
| US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| ME02419B (me) * | 2011-08-25 | 2016-09-20 | Merck Sharp & Dohme | Inhibitori pirimidina pde10 |
| KR101584925B1 (ko) * | 2011-09-19 | 2016-01-12 | 에프. 호프만-라 로슈 아게 | Pde10a 억제제로서의 트라이아졸로피리딘 화합물 |
| KR20140090665A (ko) | 2011-11-09 | 2014-07-17 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | 포스포디에스테라제 타입 １０ａ의 억제제로서 유용한 헤테로사이클릭 카복스아미드 |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| US9138494B2 (en) * | 2011-12-23 | 2015-09-22 | Abbvie Inc. | Radiolabeled PDE10A ligands |
| EP2841070B1 (en) * | 2012-04-24 | 2018-07-25 | Board Of Trustees Of Northern Illinois University | Design and synthesis of novel inhibitors of isoprenoid biosynthesis |
| CN104540835B (zh) | 2012-04-26 | 2017-08-08 | 百时美施贵宝公司 | 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物 |
| CN104583218B (zh) | 2012-04-26 | 2018-04-24 | 百时美施贵宝公司 | 作为蛋白酶活化受体4(par4)抑制剂用于治疗血小板聚集的咪唑并噻二唑和咪唑并吡嗪的衍生物 |
| CA2871599A1 (en) | 2012-04-26 | 2013-10-31 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| UY34980A (es) | 2012-08-17 | 2014-03-31 | Abbvie Inc | Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a |
| HK1206728A1 (en) | 2012-09-17 | 2016-01-15 | AbbVie Deutschland GmbH & Co. KG | Novel inhibitor compounds of phosphodiesterase type 10a |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| US9790203B2 (en) | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| US9200005B2 (en) | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| WO2014140184A1 (en) | 2013-03-14 | 2014-09-18 | AbbVie Deutschland GmbH & Co. KG | Novel inhibitor compounds of phosphodiesterase type 10a |
| EP2975037A4 (en) | 2013-03-15 | 2016-08-10 | Daiichi Sankyo Co Ltd | benzothiophene derivative |
| MX2016004540A (es) * | 2013-10-11 | 2016-07-21 | Hoffmann La Roche | Tiazolopirimidinonas como moduladores de la actividad de receptores de n-metil-d-aspartato (nmda). |
| CN107531696B (zh) | 2015-04-15 | 2021-03-16 | 豪夫迈·罗氏有限公司 | 作为nmda受体调节剂的吡啶并嘧啶酮类及它们的用途 |
| EP3856185A1 (en) | 2018-09-28 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| GB202002926D0 (en) | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
| WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
| GB202110990D0 (en) * | 2021-07-30 | 2021-09-15 | Benevolentai Cambridge Ltd | Organic compound and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
| US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
| US5843958A (en) * | 1996-11-27 | 1998-12-01 | Ortho Pharmaceutical Corporation | Arylpyrazoles as leukotriene inhibitors |
| MXPA06014236A (es) * | 2004-06-07 | 2007-02-14 | Pfizer Prod Inc | Inhibicion de la fosfodiesterasa 10 como tratamiento para las afecciones relacionadas con el sindrome metabolico y con la obesidad. |
| BRPI0518508A2 (pt) * | 2005-01-07 | 2008-11-25 | Pfizer Prod Inc | compostos de quinolina heteroaromÁticos e seu uso como inibidores de pde10 |
-
2006
- 2006-12-21 NL NL2000397A patent/NL2000397C2/nl not_active IP Right Cessation
- 2006-12-27 CA CA002636264A patent/CA2636264A1/en not_active Abandoned
- 2006-12-27 JP JP2008549069A patent/JP2009522346A/ja not_active Withdrawn
- 2006-12-27 EP EP06831852A patent/EP1979343A2/en not_active Withdrawn
- 2006-12-27 WO PCT/IB2006/003875 patent/WO2007077490A2/en not_active Ceased
-
2007
- 2007-01-03 PE PE2007000001A patent/PE20071116A1/es not_active Application Discontinuation
- 2007-01-03 US US11/619,218 patent/US20070155779A1/en not_active Abandoned
- 2007-01-03 UY UY30080A patent/UY30080A1/es not_active Application Discontinuation
- 2007-01-04 AR ARP070100041A patent/AR058919A1/es unknown
- 2007-01-04 TW TW096100305A patent/TW200736246A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1979343A2 (en) | 2008-10-15 |
| JP2009522346A (ja) | 2009-06-11 |
| WO2007077490A2 (en) | 2007-07-12 |
| TW200736246A (en) | 2007-10-01 |
| CA2636264A1 (en) | 2007-07-12 |
| NL2000397A1 (nl) | 2007-07-06 |
| US20070155779A1 (en) | 2007-07-05 |
| NL2000397C2 (nl) | 2007-10-30 |
| UY30080A1 (es) | 2007-08-31 |
| WO2007077490A3 (en) | 2007-10-04 |
| AR058919A1 (es) | 2008-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20071116A1 (es) | Compuestos de heteroarilo biciclicos como inhibidores de pde10 | |
| PE20090449A1 (es) | Agonistas de receptor acoplado a proteina g gpr119 de piridona | |
| PE20081345A1 (es) | Compuestos heterociclicos que contienen nitrogeno como agonistas del receptor nicotinico | |
| PE20121045A1 (es) | Agonista de gpr119 | |
| PE20091842A1 (es) | Pirrolidinonas como activadores de glucoquinasa | |
| PE20081151A1 (es) | Derivados de imidazol como activadores del receptor de adenosina a2a | |
| PE20080361A1 (es) | Compuestos derivados de purina como activadores del receptor de adenosina a2a | |
| PE20091724A1 (es) | Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7 | |
| PE20071152A1 (es) | Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 | |
| PE20090714A1 (es) | Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido | |
| PE20140236A1 (es) | IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS | |
| PE20120693A1 (es) | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) | |
| PE20081409A1 (es) | Antagonistas del receptor de progesterona | |
| PE20141203A1 (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| PE20120218A1 (es) | Compuestos para el tratamiento de trastornos metabolicos | |
| PE20081659A1 (es) | Agonistas de gpcr | |
| PE20091527A1 (es) | Derivados de piridazinona | |
| EA200500172A1 (ru) | Азабициклопроизводные в качестве антагонистов мускариновых рецепторов | |
| PE20081735A1 (es) | Derivados de 1-oxa-3[4,5]decan-2-ona en el tratamiento de trastornos alimenticios | |
| PE20081665A1 (es) | Antagonistas del receptor de dopamina 2 de rapida disociacion | |
| GT200600030A (es) | 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2 | |
| DE602008003221D1 (de) | Prolinamidderivate als nk3-antagonisten | |
| PE20060625A1 (es) | Derivados de benzazepina como antagonistas y/o agonistas del receptor h3 de histamina | |
| PE20070750A1 (es) | COMPUESTOS DERIVADOS DE 1-AZA-BICICLONONANO COMO LIGANDOS COLINERGICOS DEL RECEPTOR DE ACETILCOLINA NICOTINICA (nAChR) | |
| ATE400553T1 (de) | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |