PE20070326A1 - Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol - Google Patents
Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanolInfo
- Publication number
- PE20070326A1 PE20070326A1 PE2006000749A PE2006000749A PE20070326A1 PE 20070326 A1 PE20070326 A1 PE 20070326A1 PE 2006000749 A PE2006000749 A PE 2006000749A PE 2006000749 A PE2006000749 A PE 2006000749A PE 20070326 A1 PE20070326 A1 PE 20070326A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- compounds
- cyclohexanol
- methyl
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 4-HYDROXYPHENYL Chemical class 0.000 title abstract 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- VXJPCEOTZNHHOA-UHFFFAOYSA-N [K].OC Chemical compound [K].OC VXJPCEOTZNHHOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 abstract 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 abstract 1
- 239000000347 magnesium hydroxide Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 1-[CIANO(FENIL)METIL]CICLOHEXANOL DE FORMULA (I), DONDE R1 ES H, ALQUILO(C1-C4) O ALCOXI(C1-C4), QUE COMPRENDE A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON CICLOHEXANONA EN PRESENCIA DE UNA BASE ORGANICA TAL COMO ALCOHOLATO DE SODIO Y DE POTASIO DE METANOL, ALCOHOLATO DE MAGNESIO DE ETANOL, ALCOHOLATO DE ALUMINIO DE METANOL, ENTRE OTROS, QUE SE ENCUENTRA EN UNA CANTIDAD DE 1,0 A 2,5 MOLES, O INORGANICA TAL COMO HIDROXIDO DE SADIO, DE POTASIO, DE MAGNESIO, ENTRE OTROS, UTILIZADOS EN COMBINACION CON UN ALCOHOL; Y OPCIONALMENTE EN PRESENCIA DE UN DISOLVENTE INERTE TAL COMO PENTANO, HEXANO, BENCENO, ENTRE OTROS; B) AILAR EL PRODUCTO DESPUES DE ANADIR EL DISOLVENTE; Y C) PURIFICAR EL PRODUCTO. DICHA REACCION SE LLEVA A CABO A UNA TEMPERATURA DE 15ºC A 25ºC. DICHOS COMPUESTOS OBTENIDOS SON INTERMEDIARIOS PARA LA PREPARACION DE O-DESMETIL-VENLAFAXINA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH11012005 | 2005-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070326A1 true PE20070326A1 (es) | 2007-05-30 |
Family
ID=35945318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000749A PE20070326A1 (es) | 2005-06-29 | 2006-06-28 | Procedimiento para la preparacion de compuestos de 1-[ciano(4-hidroxifenil)metil]ciclohexanol |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20070021627A1 (es) |
| EP (1) | EP1902015A1 (es) |
| JP (1) | JP2008546818A (es) |
| KR (1) | KR20080031910A (es) |
| CN (1) | CN101238094A (es) |
| AR (1) | AR057416A1 (es) |
| AU (1) | AU2006264012A1 (es) |
| BR (1) | BRPI0612896A2 (es) |
| CA (1) | CA2613689A1 (es) |
| CR (1) | CR9665A (es) |
| EC (1) | ECSP088115A (es) |
| GT (1) | GT200600284A (es) |
| IL (1) | IL188070A0 (es) |
| MX (1) | MX2007016049A (es) |
| NO (1) | NO20080447L (es) |
| PE (1) | PE20070326A1 (es) |
| RU (1) | RU2008103285A (es) |
| SV (1) | SV2007002591A (es) |
| TW (1) | TW200704632A (es) |
| WO (1) | WO2007000294A1 (es) |
| ZA (1) | ZA200800746B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009511641A (ja) * | 2005-10-19 | 2009-03-19 | テバ ファーマシューティカル インダストリーズ リミティド | 高純度１−〔２−ジメチルアミノ−（４−メトキシフェニル）エチル〕シクロヘキサノール塩酸塩の調製方法 |
| EP1934168A2 (en) | 2006-07-26 | 2008-06-25 | Teva Pharmaceutical Industries Ltd | Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine |
| WO2008013993A2 (en) * | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
| EP2539313A2 (en) | 2010-03-29 | 2013-01-02 | Pliva Hrvatska D.O.O. | Crystal forms of o-desmethylvenlafaxine fumarate |
| DK201500161U3 (da) * | 2015-12-30 | 2016-04-25 | Ke Aarhus Holding Aps | Informationsterminal til montage på kundevogn |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE56324B1 (en) * | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
| JP2002006225A (ja) * | 2000-06-23 | 2002-01-09 | Nikon Corp | 顕微鏡照明装置 |
| US6504044B2 (en) * | 2001-02-28 | 2003-01-07 | Council Of Scientific And Industrial Research | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol |
| KR20030000217A (ko) * | 2001-06-22 | 2003-01-06 | 와이어쓰 | 시클로헥사놀 유도체의 제조방법 |
-
2006
- 2006-06-26 MX MX2007016049A patent/MX2007016049A/es unknown
- 2006-06-26 CN CNA2006800234703A patent/CN101238094A/zh active Pending
- 2006-06-26 EP EP06762178A patent/EP1902015A1/en not_active Withdrawn
- 2006-06-26 CA CA002613689A patent/CA2613689A1/en not_active Abandoned
- 2006-06-26 JP JP2008518691A patent/JP2008546818A/ja not_active Withdrawn
- 2006-06-26 WO PCT/EP2006/006126 patent/WO2007000294A1/en not_active Ceased
- 2006-06-26 AU AU2006264012A patent/AU2006264012A1/en not_active Abandoned
- 2006-06-26 BR BRPI0612896-3A patent/BRPI0612896A2/pt not_active Application Discontinuation
- 2006-06-26 RU RU2008103285/04A patent/RU2008103285A/ru unknown
- 2006-06-26 KR KR1020087002195A patent/KR20080031910A/ko not_active Withdrawn
- 2006-06-28 PE PE2006000749A patent/PE20070326A1/es not_active Application Discontinuation
- 2006-06-28 TW TW095123249A patent/TW200704632A/zh unknown
- 2006-06-28 AR ARP060102794A patent/AR057416A1/es unknown
- 2006-06-29 US US11/478,154 patent/US20070021627A1/en not_active Abandoned
- 2006-06-29 SV SV2006002591A patent/SV2007002591A/es not_active Application Discontinuation
- 2006-06-29 GT GT200600284A patent/GT200600284A/es unknown
-
2007
- 2007-12-12 IL IL188070A patent/IL188070A0/en unknown
-
2008
- 2008-01-16 CR CR9665A patent/CR9665A/es not_active Application Discontinuation
- 2008-01-17 EC EC2008008115A patent/ECSP088115A/es unknown
- 2008-01-23 NO NO20080447A patent/NO20080447L/no not_active Application Discontinuation
- 2008-01-24 ZA ZA200800746A patent/ZA200800746B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2613689A1 (en) | 2007-01-04 |
| CR9665A (es) | 2008-08-21 |
| BRPI0612896A2 (pt) | 2009-12-08 |
| AR057416A1 (es) | 2007-12-05 |
| RU2008103285A (ru) | 2009-08-10 |
| US20070021627A1 (en) | 2007-01-25 |
| EP1902015A1 (en) | 2008-03-26 |
| AU2006264012A1 (en) | 2007-01-04 |
| ECSP088115A (es) | 2008-02-20 |
| JP2008546818A (ja) | 2008-12-25 |
| GT200600284A (es) | 2007-09-05 |
| ZA200800746B (en) | 2009-02-25 |
| NO20080447L (no) | 2008-01-23 |
| MX2007016049A (es) | 2008-03-10 |
| IL188070A0 (en) | 2008-03-20 |
| SV2007002591A (es) | 2007-02-27 |
| CN101238094A (zh) | 2008-08-06 |
| KR20080031910A (ko) | 2008-04-11 |
| WO2007000294A1 (en) | 2007-01-04 |
| TW200704632A (en) | 2007-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |