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PE20070324A1 - Uso de moduladores no esteroides de receptores de progesterona - Google Patents

Uso de moduladores no esteroides de receptores de progesterona

Info

Publication number
PE20070324A1
PE20070324A1 PE2006000731A PE2006000731A PE20070324A1 PE 20070324 A1 PE20070324 A1 PE 20070324A1 PE 2006000731 A PE2006000731 A PE 2006000731A PE 2006000731 A PE2006000731 A PE 2006000731A PE 20070324 A1 PE20070324 A1 PE 20070324A1
Authority
PE
Peru
Prior art keywords
alkyl
dihydroisobenzofuran
oxo
alkenyl
hydroxy
Prior art date
Application number
PE2006000731A
Other languages
English (en)
Inventor
Ulrike Fuhrmann
Carsten Moller
Wolfgang Schwede
Anja Schmidt
Norbert Schmees
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20070324A1 publication Critical patent/PE20070324A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES ARILO(C6-C14) O HETEROARILO DE 5 A 14 MIEMBROS QUE TIENE DE 1 A 4 HETEROATOMOS OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C5), ALQUENILO(C2-C5), CICLOALQUILO(C3-C8), ENTRE OTROS; R2 Y R3 SON H, ALQUILO(C1-C5) O R2 Y R3 FORMAN JUNTO CON EL CARBONO DE LA CADENA UN ANILLO DE 3 A 8 ATOMOS DE CARBONO; R4 ES CH2 O C=O; R5 ES UN ANILLO CARBOCICLICO, HETEROCICLICO, ENTRE OTROS OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C8), ALQUENILO(C2-C8) O ARILHALOALQUILO(C1-C8); R6 ES UN COMPUESTO DE FORMULA (A), (B), ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C5), ALQUENILO(C2-C5), ALCOXI(C1-C5), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (1-OXO-1,3-DIHIDROISOBENZOFURAN-5-IL)AMIDA DEL ACIDO 2-BENCIL-2-HIDROXI-4-METIL-4-FENILPENTANOICO, (1-OXO-1,3-DIHIDROISOBENZOFURAN-5-IL)AMIDA DEL ACIDO 2-HIDROXI-4-METIL-2,4-DIFENILPENTANOICO, (1-OXO-1,3-DIHIDROISOBENZOFURAN-5-IL)AMIDA DEL ACIDO 2-HIDROXI-4-METIL-2-FENETIL-4-FENILPENTANOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES NO ESTEROIDES DE RECEPTORES DE PROGESTERONA SIENDO UTILES EN EL TRATAMIENTO DE ENDOMETRIOSIS, LEIOMIOMAS DE UTERO, CARCINOMA DE MAMA, DE OVARIO
PE2006000731A 2005-06-24 2006-06-26 Uso de moduladores no esteroides de receptores de progesterona PE20070324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005030293A DE102005030293A1 (de) 2005-06-24 2005-06-24 Verwendung von nichtsteroidale Progesteronrezeptor-Modulatoren

Publications (1)

Publication Number Publication Date
PE20070324A1 true PE20070324A1 (es) 2007-04-12

Family

ID=37421093

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000731A PE20070324A1 (es) 2005-06-24 2006-06-26 Uso de moduladores no esteroides de receptores de progesterona

Country Status (12)

Country Link
US (1) US20060293317A1 (es)
EP (1) EP1895999A1 (es)
JP (1) JP2008543906A (es)
AR (1) AR054803A1 (es)
CA (1) CA2612161A1 (es)
DE (1) DE102005030293A1 (es)
DO (1) DOP2006000147A (es)
GT (1) GT200600270A (es)
PE (1) PE20070324A1 (es)
TW (1) TW200726461A (es)
UY (1) UY29625A1 (es)
WO (1) WO2007022824A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
US20090099147A1 (en) * 2007-07-10 2009-04-16 Schwede Wolfgnag Non-steroidal progesterone receptor modulators
DE102007058747A1 (de) * 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2070909A1 (de) * 2007-12-15 2009-06-17 Bayer Schering Pharma AG Nichtsteroidale Progesteronrezeptor-Modulatoren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
US6245804B1 (en) * 1997-05-30 2001-06-12 Schering Aktiengesellschaft Nonsteroidal gestagens
DE60309829T2 (de) * 2002-01-14 2007-09-13 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Glucocorticoidmimetika, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische formulierungen und ihre verwendungen
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
US20050090559A1 (en) * 2003-07-01 2005-04-28 Markus Berger Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents
RS20050974A (sr) * 2003-07-01 2007-09-21 Schering Aktiengesellschaft, Heterociklično supstituisani pentanol-derivati,postupak za njihovo dobijanje i njihova primena kao supresora zapaljenja

Also Published As

Publication number Publication date
DOP2006000147A (es) 2006-12-31
TW200726461A (en) 2007-07-16
EP1895999A1 (en) 2008-03-12
WO2007022824A1 (en) 2007-03-01
JP2008543906A (ja) 2008-12-04
CA2612161A1 (en) 2007-03-01
UY29625A1 (es) 2007-01-31
AR054803A1 (es) 2007-07-18
GT200600270A (es) 2008-05-05
DE102005030293A1 (de) 2007-01-04
US20060293317A1 (en) 2006-12-28

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