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PE20070084A1 - Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-bencenamina - Google Patents

Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-bencenamina

Info

Publication number
PE20070084A1
PE20070084A1 PE2006000629A PE2006000629A PE20070084A1 PE 20070084 A1 PE20070084 A1 PE 20070084A1 PE 2006000629 A PE2006000629 A PE 2006000629A PE 2006000629 A PE2006000629 A PE 2006000629A PE 20070084 A1 PE20070084 A1 PE 20070084A1
Authority
PE
Peru
Prior art keywords
methyl
formula
imidazol
trifluoro
compound
Prior art date
Application number
PE2006000629A
Other languages
English (en)
Inventor
Murat Acemoglu
Berthold Schenkel
Song Xue
Fuentes Pedro Garcia
Banos Francisco Vicente
Medina Jose Martin
Erich Widmer
Wen-Chung Shieh
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20070084A1 publication Critical patent/PE20070084A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

REFERIDA A UN PROCEDIMIENTO DE PREPARACION DE 5-(4-METIL-1H-IMIDAZOL-1-IL)-3-(TRIFLUORO-METIL)-BENCENAMINA DE FORMULA (I), EL CUAL COMPRENDE LOS PASOS DE: a) HACER REACCIONAR EL COMPUESTO DINITROBENZOTRIFLUORURO CON 4-METIL-1H-IMIDAZOL DE FORMULA (IIIa) A UNA TEMPERATURA DE ENTRE 80ºC Y 150 ºC, PARA PREPARAR EL 4-METIL-1-(3-NITRO-5-TRIFLUORO-METIL-FENIL)-1H-IMIDAZOL DE FORMULA (III) Y b) REDUCIR EL COMPUESTO DE FORMULA (III) EN PRESENCIA DE UN CATALIZADOR TAL COMO PALADIO, PLATINO, NIQUEL DE RANEY O COMBINACIONES DE LOS MISMOS, PARA PRODUCIR EL COMPUESTO DE FORMULA (I). DICHO COMPUESTO DE FORMULA (I) ES UN INERMEDIARIO PARA LA PREPARACION DE LAS PIRIMIDINIL-AMINO-BENZAMIDAS SUSTITUYIDAS DE FORMULA (II), LOS CUALES INHIBEN UNA O MAS QUINASAS DE TIROSINA, TALES COMO c-Abl, Bcr-Abl, ENTRE OTRAS.
PE2006000629A 2005-06-09 2006-06-07 Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-bencenamina PE20070084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68892005P 2005-06-09 2005-06-09

Publications (1)

Publication Number Publication Date
PE20070084A1 true PE20070084A1 (es) 2007-03-09

Family

ID=37085334

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000629A PE20070084A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-bencenamina

Country Status (20)

Country Link
US (1) US7709657B2 (es)
EP (1) EP1896425B1 (es)
JP (1) JP5139273B2 (es)
KR (1) KR101319071B1 (es)
CN (1) CN101193866B (es)
AR (1) AR057351A1 (es)
AT (1) ATE483690T1 (es)
AU (1) AU2006258116B2 (es)
BR (1) BRPI0611924A2 (es)
CA (1) CA2610402C (es)
DE (1) DE602006017369D1 (es)
ES (1) ES2354115T3 (es)
GT (1) GT200600207A (es)
MX (1) MX2007015420A (es)
PE (1) PE20070084A1 (es)
PL (1) PL1896425T3 (es)
PT (1) PT1896425E (es)
RU (1) RU2404167C2 (es)
TW (1) TW200710084A (es)
WO (1) WO2006135619A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
GB0618832D0 (en) * 2006-09-25 2006-11-01 Phoenix Chemicals Ltd Chemical process
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
BR112016026632A2 (pt) 2014-05-16 2017-08-15 Bosch Gmbh Robert Unidade hidráulica abs
KR102335216B1 (ko) 2017-04-26 2021-12-03 삼성전자 주식회사 발광소자 패키지
CN107235910B (zh) * 2017-07-31 2020-04-24 安礼特（上海）医药科技有限公司 一种尼洛胺的合成方法
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
CN112423757A (zh) 2018-06-15 2021-02-26 汉达生技医药责任有限公司 激酶抑制剂的盐类及其组合物
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
CA2148928C (en) * 1993-10-01 2005-10-18 Jurg Zimmermann Pharmacologically active pyridine derivatives and processes for the preparation thereof
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2840303B1 (fr) 2002-05-31 2005-07-15 Rhodia Chimie Sa Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile
PE20040522A1 (es) * 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
CA2610402C (en) 2014-09-16
PL1896425T3 (pl) 2011-04-29
TW200710084A (en) 2007-03-16
EP1896425B1 (en) 2010-10-06
US7709657B2 (en) 2010-05-04
PT1896425E (pt) 2010-11-30
CN101193866A (zh) 2008-06-04
KR20080016618A (ko) 2008-02-21
JP2008545782A (ja) 2008-12-18
RU2404167C2 (ru) 2010-11-20
CA2610402A1 (en) 2006-12-21
ES2354115T3 (es) 2011-03-10
AR057351A1 (es) 2007-11-28
RU2007147927A (ru) 2009-07-20
AU2006258116B2 (en) 2010-11-25
EP1896425A1 (en) 2008-03-12
ATE483690T1 (de) 2010-10-15
GT200600207A (es) 2007-01-15
CN101193866B (zh) 2011-01-19
US20080200691A1 (en) 2008-08-21
MX2007015420A (es) 2008-02-21
JP5139273B2 (ja) 2013-02-06
WO2006135619A1 (en) 2006-12-21
AU2006258116A1 (en) 2006-12-21
BRPI0611924A2 (pt) 2010-10-05
DE602006017369D1 (de) 2010-11-18
KR101319071B1 (ko) 2013-10-17

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